Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway [0.03%]
衰老细胞通过强大的NF-κB途径促进病毒感染相关的炎症和组织损伤
Mingfu Tian,June Ma,Zhiqiang Li et al.
Mingfu Tian et al.
Respiratory virus infections have been presenting significant global public health challenges. The virulence of SARS-CoV-2 and seasonal influenza largely relies on triggering abnormal host immune responses, particularly the production of a ...
SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment [0.03%]
SLC7A11在铁死亡和二硫化物依赖型细胞焦亡（硫死亡）间架桥作用：肿瘤治疗的新靶点
Hui Qiu,Jing Liu,Nan Shao et al.
Hui Qiu et al.
Cell death is a basic physiological process involved in embryonic development, aging, immune responses and other life processes. In particular, ferroptosis and disulfidptosis are two forms of regulatory cell death (RCD) that have been ident...
GAS5 as a therapeutic target in breast cancer through apoptosis induction [0.03%]
GAS5在乳腺癌治疗中的靶点作用及其促凋亡机制研究
Alisha Badal,Zelinda Engelbrecht,Marianne J Cronjé
Alisha Badal
The ongoing discovery of long noncoding RNA (lncRNA) involvement in carcinogenesis prevention and development has made significant strides in breast cancer therapeutics. lncRNA growth arrest-specific 5 (GAS5) is downregulated in breast canc...
2-chlorofatty acid modification of neutrophil proteins: identification, localization and role in NETosis [0.03%]
中性粒细胞蛋白的2-氯脂肪酸修饰：鉴定、定位及其在NETosis中的作用
Haley L Carlson,Reagan M McGuffee,Rakesh P Patel et al.
Haley L Carlson et al.
We previously demonstrated neutrophil MPO derived HOCl targets the vinyl ether bond of plasmalogens resulting in the Liberation of 2-chlorofatty aldehydes (2-ClFALDs) and their oxidation products, 2-chlorofatty acids (2-ClFAs), which elicit...
Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy [0.03%]
微生物战争的转译调控武器：细菌效应物如何操控宿主细胞死亡和异噬作用
Kun Meng,Liuliu Shi,Xianglan Fang et al.
Kun Meng et al.
The intricate interplay between pathogenic bacteria and host cellular processes represents a dynamic molecular battlefield during infection. Mammalian hosts employ two critical cell-autonomous defense mechanisms, regulated cell death (RCD) ...
Correction: Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis [0.03%]
纠正：子宫内膜癌（EC）衍生的G3BP1过表达和突变通过SPOP/ERα轴促进EC肿瘤发生和转移
Yidong Ge,Jiabei Jin,Gun Chen et al.
Yidong Ge et al.
Epigenetic reprogramming of dendritic cells by DNMT1 inhibition attenuates Th2 skewing in allergic airway inflammation [0.03%]
DNMT1抑制引起的树突状细胞表观遗传重编程在过敏性气道炎症中削弱Th2偏移作用机制研究
Jinmei Xue,Yisha Wu,Zhizhen Liu et al.
Jinmei Xue et al.
Background: Allergic asthma is driven by Th2-polarized immune responses, yet the epigenetic mechanisms underlying dendritic cell (DC)-mediated Th2 skewing remain unclear. ...
Maria F Unger,Vijay Velagala,Dharsan K Soundarrajan et al.
Maria F Unger et al.
The G protein alpha subunit, Gαq, transduces extracellular signals from G-protein-coupled receptors (GPCRs) into the cell, playing essential roles in developmental processes such as organ size control, wound healing, and disease. Hyperacti...
The hidden driver of osteoporosis: mitochondria-dominated inflammation [0.03%]
骨质疏松症的隐秘驱动因素：以线粒体为主的炎症作用
Binghan Yan,Wenhan Ju,Haipeng Xue et al.
Binghan Yan et al.
Mitochondria are powerful multifunctional intracellular organelles involved in a wide array of cellular processes. Emerging evidence has highlighted mitochondria as pivotal activators of innate immunity and key participants in inflammatory ...
Bowen Liu,Xin Chen,Jin Wang et al.
Bowen Liu et al.