Specific transformation of steviol at unactivated C-H sites by microorganism and mining of key P450 enzymes [0.03%]
微生物催化 steviol 特定C-H位点转化及关键P450酶挖掘
Changchun Liu,Dian Zou,Biaobiao Luo et al.
Changchun Liu et al.
Enzyme engineering has witnessed substantial advancements, particularly in the application of intricate microbial enzyme systems to substrate modification. Steviol (ST), a diterpenoid compound characterised by a typical shell diene skeleton...
A new seco-norlignan and a rare ring B aromatic 1(10→6) abeo-ergostane-type steroid from Tarlmounia elliptica [0.03%]
从毛叶苔草中分离的一个新型双氢诺里格木素和一种罕见的B环芳香烃类1(10→6)abeo- Ergostan型甾醇类化合物
Qiao-Long Hao,Han-Mei Bai,Lei Miao et al.
Qiao-Long Hao et al.
The first phytochemical investigation of Tarlmounia elliptica (the sole species of its genus) led to the isolation of eight compounds from its aerial parts, including a previously undescribed seco-norlignan, tarlelliptin A (1), and a rare r...
Isolation and in vitro anticancer activity evaluation of three previously undescribed compounds together with other constituents of Ficus iteophylla Miq (Moraceae)† [0.03%]
三种之前未被描述的菲库斯次生代谢产物的分离及其体外抗肿瘤活性评价
Muriel A Akamse,Renameditswe Mapitse,Christian D Fozing et al.
Muriel A Akamse et al.
The chemical investigation of the stem bark of Ficus iteophylla Miq. has resulted in the isolation of three previously undescribed compounds: iteophylupeol (1), iteophenylcoumarin (2), and iteophylisoflavone (3), alongside 12 known compound...
16,17-Dihydro-ophiobolin X: a novel cytotoxic sesterterpenoid from the endophyte Penicillium ochrochloron YT2022-65 [0.03%]
来自内生真菌Penicillium ochrochloron YT2022-65的新倍半萜醌16,17-二氢奥吡波林X
Li Xian,Ruonan Li,Xingjie Liu et al.
Li Xian et al.
Chemical investigation of Penicillium ochrochloron YT2022-65, an endophytic fungus obtained from Lonicera japonica, led to the isolation of six structurally diversified ophiobolin derivatives, including a new compound named 16,17-dihydro-op...
Investigation of the antioxidant and anticancer properties of dragon fruit (Hylocereus undatus and Hylocereus polyrhizus) in human colon cancer [0.03%]
仙果（量天尺属）的抗氧化和抗癌症性质的人类结肠癌研究
Çiğdem Gökçek-Saraç,Nuray Bakal,Serdar Karakurt
Çiğdem Gökçek-Saraç
Antioxidant and anticancer properties of methanol extracts from dragon fruit pulp and peel (Hylocereus undatus (Haw.) Britton & Rose and Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose) in CRC were investigated. Antioxidant activity, ph...
Integrated HR-LCMS profiling and computational validation of putatively identified antibacterial flavonoids from pistacia chinensis subsp. integerrima (J.L. Stewart) Rech f. galls [0.03%]
Pistacia chinensis 子代植株虫瘿中抗菌黄酮类成分的HR-LCMS分析及可能结构预测与验证
Anuraag Rai,Sanjana Biswal,Vinod Kumar Gurjar et al.
Anuraag Rai et al.
The global antibiotic resistance crisis necessitates exploring Pistacia chinensis subsp. integerrima (J.L. Stewart ex Brandis) 'Shringi'. While traditionally used for infections, specific mechanisms of its unexplored novel flavonoids agains...
Clove oil nanoemulsion as a novel therapeutic strategy against Streptococcus mutans-induced dental caries and periodontitis [0.03%]
丁香油纳米乳液作为治疗齿垢链球菌引起的龋齿和牙周炎的新型治疗方法
Atrayee Das Gupta,Debasmita Ghosh,Debraj Ghosh et al.
Atrayee Das Gupta et al.
The present study investigates clove oil nanoemulsion (CONE) as a novel therapeutic strategy against Streptococcus mutans-induced dental caries and periodontitis. CONE was formulated via ultrasonic emulsification, yielding a stable nanoemul...
Time to embrace the whole: considering the replacement of psilocybin with Psilocybe spp. in psychedelic research and therapy [0.03%]
是时候拥抱整体：在心理疗法研究中用整株药用鹅膏替代裸盖菇素的时候了
Genís Ona,Cristina Llagostera,Oscar Alvarez et al.
Genís Ona et al.
Psilocybin, the main psychoactive compound in Psilocybe cubensis mushrooms, has gained considerable attention for its therapeutic potential. Current research focuses only on isolated psilocybin, neglecting the broader pharmacological and cu...
Semi-synthesis of novel dispiro hybrids of sesquiterpene lactones by using benzylamines via azomethine ylide cycloaddition [0.03%]
通过茋介导的亚胺基乙内酰脲环加成使用苄胺半合成novel dispiro倍半烯内酯杂化物
Aliya Tabassum,Suyog R Bhalerao,Goutam Dubey et al.
Aliya Tabassum et al.
A pair of isomeric sesquiterpenes, alantolactone and isoalantolactone, were isolated from Inula racemosa Hook. f. and utilised for the synthesis of diverse natural product hybrids using azomethine ylide cycloaddition. In this particular stu...
In vivo antioxidant and anti-inflammatory properties of ethanol leaf extract of Ficus ottoniifolia Miq. on complete Freund's adjuvant (CFA)-induced rheumatoid arthritis in albino rats [0.03%]
Ficus ottoniifolia Miq.叶乙醇提取物的体内抗氧化和抗炎作用研究及其对 Complete Freund’s Adjuvant 诱导的大鼠类风湿性关节炎的作用
ThankGod Mmaduabuchi Ogbonna,Nkiruka Nwamaka Ezeani,Obasi Uche Orji
ThankGod Mmaduabuchi Ogbonna
This study evaluated the antioxidant and anti-inflammatory effects of ethanol leaf extract of Ficus ottoniifolia in CFA-induced rheumatoid arthritis in albino rats. Thirty rats were divided into six groups (n = 5): normal control, arthritic...