Insights into knee post-traumatic osteoarthritis pathophysiology from the relationship of serum biomarkers to radiographic features in the ADVANCE cohort [0.03%]
前瞻性队列研究：血清生物学标志物与膝关节放射学表现之间的关系对膝关节创伤性骨关节炎病理生理的启示
Oliver O&#x;Sullivan,Ana M Valdes,Fraje Watson et al.
Oliver O&#x;Sullivan et al.
Introduction: Post-traumatic osteoarthritis (PTOA) is a complex condition with multiple pathological processes at play. Molecular biomarkers can enable a better understanding of these processes, thus enhancing case endoty...
Dual impact of interleukin-17 A blockade on inflammatory and stromal pathways in peripheral spondyloarthritis [0.03%]
白细胞介素17A抑制对外周型轴突关节炎炎症和基底膜途径的双重影响
Ihsan Hammoura,Renée H Fiechter,Leonieke J J van Mens et al.
Ihsan Hammoura et al.
Background: IL-17 A plays a role in the pathology of spondyloarthritis (SpA), as evidenced by the clinical efficacy of IL-17 A inhibitors (IL-17Ai). Nevertheless, the exact role of IL-17 A in driving synovial inflammation...
Stepwise dose reduction and discontinuation of bDMARD in rheumatoid arthritis: a prospective cohort study of flare-free population, flares, and predictive markers [0.03%]
类风湿关节炎逐步减量停用bDMARD的队列研究：无病情加重人群、病情加重及预测指标
Yuji Nozaki,Kazuya Kishimoto,Daisuke Tomita et al.
Yuji Nozaki et al.
Background: This study investigated the clinical outcomes of stepwise dose-reduction and discontinuation protocols for biological disease-modifying anti-rheumatic drugs (bDMARD) in patients with stable rheumatoid arthriti...
The SCRIM score: a clinical tool for cancer risk-stratification in patients with idiopathic inflammatory myopathy [0.03%]
SCRIM评分：肌炎患者癌症风险分层的临床工具
Yun Kyu Kim,Jung Yoon Pyo,Ju Yeon Kim et al.
Yun Kyu Kim et al.
Background: Although patients with idiopathic inflammatory myopathy (IIM) have a higher cancer risk than the general population, this risk varies among IIM patients based on clinical factors such as IIM subtype, clinical ...
Clinical and ultrasound remission at 48 weeks of upadacitinib in rheumatoid arthritis: real-world results from the Italian multicenter UPARAREMUS study [0.03%]
乌帕替尼治疗类风湿关节炎的临床和超声缓解：意大利多中心UPARAREMUS研究的真实世界结果
Andrea Picchianti Diamanti,Valentino Paci,Michele Maria Luchetti Gentiloni et al.
Andrea Picchianti Diamanti et al.
Background: Achieving clinical remission is a key therapeutic goal in rheumatoid arthritis (RA). While pivotal trials and early real-world studies have demonstrated the efficacy of upadacitinib (UPA), data on its impact a...
Observational Study
Arthritis research & therapy. 2025 Nov 3;27(1):203. DOI:10.1186/s13075-025-03671-z 2025
Long-term comparative analysis of secukinumab versus TNFα inhibitors in patients with spondyloarthritis: treatment persistence is differentially affected by disease phenotype, obesity and sex [0.03%]
银屑病关节炎患者中司库奇尤单抗与TNF抑制剂长期比较分析：疗效持续时间受疾病特征、肥胖和性别影响不同
Irini D Flouri,Argyro Repa,Nestor Avgoustidis et al.
Irini D Flouri et al.
Background: The anti-interleukin 17A agent secukinumab has been approved for the treatment of spondyloarthritis (SpA) patients as an alternative to tumor necrosis factor inhibitors (TNFis). Our aim was to compare long-ter...
Comparative Study
Arthritis research & therapy. 2025 Nov 3;27(1):202. DOI:10.1186/s13075-025-03664-y 2025
Efficacy and safety of tofacitinib treatment in Finnish patients with juvenile idiopathic arthritis: a real-life study [0.03%]
托法替尼治疗芬兰青年特发性关节炎患者的有效性和安全性：一项真实世界研究
Tiina Levälampi,Katariina Rebane,Katriina Mikola et al.
Tiina Levälampi et al.
Background: Tofacitinib (TOFA), a newly introduced Janus kinase inhibitor, has been approved for the treatment of juvenile idiopathic arthritis (JIA). In this real-life study, we describe the effectiveness of TOFA treatme...
How to score the wrist joint by ultrasound: exploration of the most sensitive joint assessment during follow-up of early or established rheumatoid arthritis [0.03%]
腕关节超声评分方法探讨：早期或已确立类风湿性关节炎随访中最敏感的关节评价指标探索研究
Yusuke Yoshida,Hilde Berner Hammer,Joseph Sexton et al.
Yusuke Yoshida et al.
Background: Wrist inflammation is common in patients with rheumatoid arthritis (RA), and thus there is room for debate on which joints to include in an ultrasound-based scoring of wrist synovitis in RA. This study aimed t...
Epidemiological trends of osteoarthritis at the global, regional, and national levels from 1990 to 2021 and projections to 2050 [0.03%]
1990至2021年全球、区域和国家各级骨关节炎流行趋势及2050年前预测值
Lichun Qiao,Miaoqian Li,Feidan Deng et al.
Lichun Qiao et al.
Background: Osteoarthritis is a major cause of disability worldwide, and understanding epidemiological trends in osteoarthritis is critical for public health planning and intervention strategies. ...
Effectiveness and safety of tacrolimus in systemic lupus erythematosus with various clinical manifestations: a retrospective real-world study [0.03%]
他克莫司治疗不同临床分型成人系统性红斑狼疮疗效及安全性的真实世界研究
Wei Bai,Hui Luo,Huaxiang Wu et al.
Wei Bai et al.
Objective: This study evaluated the real-world effectiveness and safety of tacrolimus as a steroid-sparing maintenance therapy alone without additional biologics or immunosuppressive medications in systemic lupus erythema...