Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease [0.03%]
单细胞测序揭示了抗MDA5抗体阳性皮肌炎中快速进展性间质性肺病的外周免疫反应的差异
Chenghua Weng,Enzhuo Liu,Hui Zheng et al.
Chenghua Weng et al.
Background: Anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis (MDA5+ DM) is an autoimmune disease related to rapidly progressive interstitial lung disease (RPILD) with high mortality. Ho...
Real-world sex differences in treatment persistence and reasons for discontinuation in psoriatic arthritis patients: results from the German RABBIT-SpA register [0.03%]
德国RABBIT-脊柱关节炎登记处的真实世界中银屑病性关节炎患者的治疗持续时间的性别差异及停药原因分析结果
Lisa Lindner,Anja Weiß,Andreas Reich et al.
Lisa Lindner et al.
Background: In psoriatic arthritis (PsA), growing evidence indicates sex-specific differences regarding clinical manifestation and treatment outcomes. Research has highlighted that females may be less likely to achieve tr...
Real-world sex differences in treatment persistence and reasons for discontinuation in psoriatic arthritis patients: results from the German RABBIT-SpA register [0.03%]
德国RABBIT-SpA登记处的真实世界中银屑病关节炎患者的治疗持续时间的性别差异及停药原因分析结果
Lisa Lindner,Anja Weiß,Andreas Reich et al.
Lisa Lindner et al.
Background: In psoriatic arthritis (PsA), growing evidence indicates sex-specific differences regarding clinical manifestation and treatment outcomes. Research has highlighted that females may be less likely to achieve tr...
The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis [0.03%]
BMS-470539的衰老样活性与皮肤纤维化模型中抗纤维化作用相关性研究
Camilla Sa Davan-Wetton,Natalya Khodeneva,Christopher P Denton et al.
Camilla Sa Davan-Wetton et al.
Background: Conditions like fibrosis, rheumatoid arthritis or cancer, once seen as distinct diseases, are now recognized to share strikingly common pathogenic mechanisms. The key to this convergence lies in the fibroblast...
Longitudinal assessment of circulating fibroblast activation protein in systemic sclerosis-associated interstitial lung disease [0.03%]
系统性硬化症相关间质性肺病中外周血成纤维细胞活化蛋白的纵向评估
Bo Broens,Conny J van der Laken,Iris A Simons et al.
Bo Broens et al.
Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is difficult to manage due to the heterogeneous disease course. There is a high need for new biomarkers to identify patients at high risk for I...
Sacroiliac joint involvement in psoriatic arthritis - MRI, radiographic and clinical findings in 581 European routine care patients [0.03%]
欧洲地区581例银屑病关节炎患者的常规护理中骶髂关节病变的磁共振、放射学和临床特征
Nora Vladimirova,Anna Ef Hadsbjerg,Simon Krabbe et al.
Nora Vladimirova et al.
Background: Axial involvement in psoriatic arthritis (axPsA) is associated with more severe disease and increased pain, yet no consensus definition of axPsA exists. This study aims to describe the occurrence and character...
Low-dose rituximab in lupus enteritis: a comparative study on its efficacy in modulating mucosal immunity and reducing inflammation [0.03%]
小剂量利妥昔单抗治疗狼疮性肠炎的疗效及其调节黏膜免疫和减少炎症作用的比较研究
Ying Liu,YuJie Pang,Yang Liu et al.
Ying Liu et al.
Background: Lupus enteritis (LE) is a serious manifestation of systemic lupus erythematosus (SLE), yet optimal treatment strategies remain unclear. This study aimed to compare the efficacy of rituximab (RTX) plus glucocor...
Comparative Study
Arthritis research & therapy. 2025 Sep 29;27(1):183. DOI:10.1186/s13075-025-03653-1 2025
Evolution from early to difficult-to-treat rheumatoid arthritis: incidence and risk factors in the ERA uclouvain Brussels cohort [0.03%]
从早期类风湿关节炎发展到难治性类风湿关节炎的演变：ERA-UCLLouvain布鲁塞尔队列中的发病率和危险因素
Francesco Natalucci,Clément Triaille,Emilie Sapart et al.
Francesco Natalucci et al.
Background: Despite an increasing number of targeted and biological disease-modifying anti-rheumatic drugs (ts or bDMARDs), a significant number of Rheumatoid Arthritis (RA) patients are refractory to multiple lines of tr...
Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort [0.03%]
基于人群的纵向队列中肥胖指数变化模式与类风湿性关节炎发病风险之间的关系证据
Xuanli Zhao,Xiaohui Sun,Fuhua Wu et al.
Xuanli Zhao et al.
Background: Obesity has been linked to increased rheumatoid arthritis (RA) risk, but the impact of longitudinal changes in obesity indices remains unclear. A clearer understanding of these dynamic patterns could enhance e...
Bone marrow lesion coexisted with subchondral bone attrition and/or subchondral bone cyst is associated with knee pain in knee osteoarthritis regardless of cartilage lesion: the Bunkyo health study [0.03%]
骨髓病变与股骨头下骨损耗和/或股骨头下囊肿与膝骨关节炎的软骨病变无关，但与其膝痛相关：文京健康研究
Jun Tomura,Haruka Kaneko,Arepati Adili et al.
Jun Tomura et al.
Background: Subchondral bone changes, which include bone marrow lesion (BML), subchondral bone attrition (SBA) and subchondral bone cyst (SBC) by magnetic resonance imaging (MRI) analysis, are reportedly implicated for kn...