Mutant IL-2-expressing mesenchymal stromal cells promote regulatory T cells proliferation and activation in collagen induced arthritis mice [0.03%]
表达IL-2突变型间充质干细胞促进胶原诱导型关节炎小鼠调节性T细胞增殖及活化
Zhicheng Tang,Fan Yang,Jingyi Shen et al.
Zhicheng Tang et al.
Objectives: Research indicates that low doses of interleukin-2 (IL-2) can effectively mitigate Rheumatoid arthritis (RA) symptoms by promoting Treg cells, while high doses may enhance immune responses and exacerbate the d...
IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis [0.03%]
IRF7在类风湿关节炎中调控促炎性巨噬细胞极化及关节破坏
Huatao Liu,Changhua Wu,Guojian Li et al.
Huatao Liu et al.
Inhibition of NOX4 attenuates muscle damage and mitochondrial dysfunction in inflammatory myopathy [0.03%]
NOX4抑制可缓解炎症肌病中的肌肉损伤和线粒体功能障碍
Hae Rim Kang,Jeong Yeon Kim,Seon Uk Kim et al.
Hae Rim Kang et al.
Background: Idiopathic inflammatory myopathy (IIM) is a chronic autoimmune disorder characterized by muscle inflammation and weakness. If a muscle is already damaged, muscle strength often fails to restore with current tr...
Association between sleep disorders and rheumatoid arthritis in U.S. adults [0.03%]
美国成年人睡眠障碍与类风湿性关节炎的关系
Liujie Zheng,Guoqiang Li,Zhiyong Hou
Liujie Zheng
Background: Evidence on the association between sleep disorders and rheumatoid arthritis (RA) remains limited. This study aimed to investigate this relationship in U.S. adults using data from the National Health and Nutri...
Chimeric antigen receptor (CAR) therapies for precise eradication of pathogenic cells in autoimmunity [0.03%]
嵌合抗原受体(CAR)疗法在自身免疫病中精准清除致病细胞的作用
George D Kalliolias,Efthimia K Basdra,Athanasios G Papavassiliou
George D Kalliolias
CAR-T cells (CAR-Ts) are genetically engineered T lymphocytes to express a receptor construct bearing an extracellular recognition domain that guides the killing specificity, a transmembrane domain, and an intracellular domain that elicits ...
Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis [0.03%]
外周辅助性T细胞的循环与肉芽肿性多血管炎的疾病活动度增加相关
Hang Liao,Nanthicha Inrueangsri,Matthew A Jackson-Wood et al.
Hang Liao et al.
Objectives: Peripheral helper T (Tph) cells, a recently identified Th cell subset, have been implicated in various autoimmune diseases. However, their role in granulomatosis with polyangiitis (GPA) remains unclear. This s...
Exercise-Dependent effects of substance P deficiency on joint degeneration and inflammation in a surgical mouse model of osteoarthritis [0.03%]
物质P缺乏对骨关节炎手术小鼠模型中关节退行性变和炎症的影响受运动依赖性调节
Patrick Pann,Paul Kalke,Verena Maier et al.
Patrick Pann et al.
Background: Osteoarthritis (OA) is a chronic degenerative joint disease driven by multifactorial causes, including aging, mechanical stress, and inflammation. Mechanical loading through exercise can either exacerbate or a...
Transcriptome analysis unveils Th1 cell cycle signature as a distinctive feature of mixed connective tissue disease [0.03%]
转录组分析揭示Th1细胞周期特征为重叠性结缔组织病的显著标志
Yuichi Suwa,Yasuo Nagafuchi,Saeko Yamada et al.
Yuichi Suwa et al.
Objectives: Mixed connective tissue disease (MCTD) is characterized by positivity for anti-U1-RNP antibodies and a combination of symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and inflammatory ...
Maternal-fetal outcomes and therapeutic strategies in pregnancies complicated by Takayasu arteritis: a comprehensive analysis [0.03%]
塔克曜氏动脉炎妊娠并发症的母胎结局及治疗策略：全面分析
Wangjin Chen,Ruilian Xie,Yushuang Xiao et al.
Wangjin Chen et al.
Objective: To evaluate maternal-fetal outcomes and therapeutic efficacy in Takayasu arteritis (TA)-complicated pregnancies through integrated retrospective analysis and meta-analytic synthesis. ...
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases [0.03%]
优化衍生物EPI-X4靶向CXCL12 / CXCR4通路可保持软骨细胞功能并为风湿病提供新的治疗途径
Leonie Ruths,Hannah de Hesselle,Felix Haußner et al.
Leonie Ruths et al.
Background: The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous. However, it is assumed that the CXCL12...