Baricitinib ameliorates skin fibrosis via direct fibroblast suppression and endothelial exosome-mediated paracrine signaling [0.03%]
巴利昔单抗通过直接抑制成纤维细胞和内皮细胞外泌体介导的旁分泌信号改善皮肤纤维化
Zhanying Hou,Xiufeng Zhao,Fang Liu et al.
Zhanying Hou et al.
Safety of JAK inhibitors versus other biologic therapies following anti-TNF failure in patients with rheumatoid arthritis [0.03%]
抗TNF治疗失败的类风湿关节炎患者接受JAK抑制剂与其它生物制剂治疗的安全性比较
Lorenzo Di Luozzo,Mariangela Salvato,Francesca Frizzera et al.
Lorenzo Di Luozzo et al.
Background: Treatment of rheumatoid arthritis (RA) frequently requires Janus kinase inhibitors (JAKi) and biologic DMARDs (bDMARDs) with other mechanisms of action (OMA) after tumour necrosis factor inhibitors (TNFi) fail...
Comparative Study
Arthritis research & therapy. 2025 Dec 19;27(1):227. DOI:10.1186/s13075-025-03686-6 2025
The association of intensity of joint pain and health-related quality of life among adults with arthritis: a large population-based cross-sectional study [0.03%]
中国成人关节炎患者关节痛强度与健康相关生活质量之间的关联：一项基于人口的大规模横断面研究
Gang Zhao,Yunqi Chu,Panying Sun et al.
Gang Zhao et al.
Background: Arthritis imposes serious health consequences, including substantial disability and increased risk of all-cause mortality. Prior studies have reported that pain was associated with decreased health-related qua...
Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement [0.03%]
轴型脊柱关节炎与附着点炎性病变的银屑病关节炎患者的放射学脊柱变化及其进展的比较
Philipp Sewerin,Imke Redeker,Eirini Lavda et al.
Philipp Sewerin et al.
Background: Psoriatic arthritis with inflammatory axial involvement (PsA-ax) and axial spondyloarthritis (axSpA) are distinct entities within the spectrum of spondyloarthritides. Despite overlapping clinical and imaging f...
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA [0.03%]
RNF152介导的HSP27泛素依赖性降解活化PI3K/AKT通路驱动TMJOA滑膜炎性级联反应
Xinjian Zhang,Qingkun Jiang,Wei Deng et al.
Xinjian Zhang et al.
Compositional patterns of device-measured movement behaviour in juvenile idiopathic arthritis: results from the multicentre ActiMON study [0.03%]
少关节炎儿童设备测量的运动行为模式：来自多中心ActiMON研究的结果
Florian Milatz,Lisa Voigt,Jens Klotsche et al.
Florian Milatz et al.
Bone marrow mesenchymal stem cell-derived exosomes improve pyroptosis and mitochondrial integrity through miR-515-5p-mediated TLR4/NLRP3/GSDMD axis in rheumatoid arthritis [0.03%]
骨髓间充质干细胞衍生的外泌体通过miR-515-5p介导的TLR4/NLRP3/GSDMD轴改善类风湿关节炎中的焦亡和线粒体完整性
Dongfeng Cai,Chao Zhong,Zixiao Yang et al.
Dongfeng Cai et al.
Background: Bone marrow mesenchymal stem cell (BMSC) therapy can significantly improve the outcomes of rheumatoid arthritis (RA). This study explores the protective role of BMSC-derived exosomes (BMSCs-Exos) in RA through...
Inflammatory gradients in the infrapatellar fat pad of knee osteoarthritis: implications for joint damage [0.03%]
膝骨关节炎股四头肌内脂肪垫中的炎症梯度：对关节损伤的影响
Shuo Yang,Peizhi Lu,Zheng Zhu et al.
Shuo Yang et al.
The infrapatellar fat pad (IFP) plays a pivotal role in the pathogenesis of knee osteoarthritis (KOA), exhibiting marked histological changes as the disease progresses. However, the intra-tissue variations within KOA-affected IFP remain poo...
Clinical significance of inflammation-coagulation-autoantibody triad in systemic sclerosis-associated interstitial lung disease: a retrospective study [0.03%]
系统性硬化症相关间质性肺病炎症-凝血-自身抗体三联体的临床意义：回顾性研究
Ronghong Guo,Xianzhe Zhou,Jiaxin Chen et al.
Ronghong Guo et al.
Background: Interstitial lung disease (ILD) is highly prevalent among systemic sclerosis (SSc) patients and is the leading cause of mortality. This study aims to evaluate the independent and combined value of inflammatory...
A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial [0.03%]
系统性硬化症改良罗纳评分预测复合生物标志物评分的启示：自身造血干细胞移植国际硬皮病试验数据
Stefano Rodolfi,Kristina Clark,Bahja Ahmed Abdi et al.
Stefano Rodolfi et al.