Give weekly adalimumab a chance before discontinuing it: a retrospective clinical and pharmacokinetic analysis in pediatric rheumatology [0.03%]
给孩子足够的机会尝试阿达木单抗失败前请勿轻易停药：儿科风湿病领域的临床及药代动力学分析回顾性研究
Francesca Burlo,Serena Pastore,Gabriele Stocco et al.
Francesca Burlo et al.
Background: Subcutaneous adalimumab is the preferred treatment for most children with juvenile idiopathic arthritis (JIA) and non-infectious uveitis, usually administered every other week. Some patients do not respond or ...
M-CSF, inducing CD163 macrophages, is associated with severity and prognosis of glomerulonephritis in microscopic polyangiitis [0.03%]
M-CSF诱导的CD163巨噬细胞与显微镜下多血管炎相关性肾小球肾炎严重程度及预后的关系
Shogo Matsuda,Takuya Kotani,Hiroko Kuwabara et al.
Shogo Matsuda et al.
SGK1 triggers cartilage degradation in TMJOA via FoxO1/autophagy [0.03%]
SGK1通过FoxO1/自噬在TMJ骨关节炎中触发软骨降解
Hongyao Tang,Chuan Ma,Mengchen Xu et al.
Hongyao Tang et al.
Background: Temporomandibular joint osteoarthritis (TMJOA) is a prevalent inflammatory disease with unclear pathogenesis. Serum and glucocorticoid-inducible kinase 1 (SGK1) has been implicated in osteoarthritis-related ca...
Sustained hippocampal neuroinflammation and subsequent glutamatergic dysfunction in juvenile idiopathic arthritis: evidence from proton magnetic resonance spectroscopy (1H-MRS) [0.03%]
儿童特发性关节炎海马区神经炎症及谷氨酸功能障碍：来自氢质子磁共振波谱(1H-MRS)的证据
Haiwei Han,Yifei Weng,Shumu Yang et al.
Haiwei Han et al.
Background: Chronic pain and psychiatric comorbidities in juvenile idiopathic arthritis (JIA) persist even during disease remission, suggesting central nervous system (CNS) alterations. This study used proton magnetic res...
Serum CXCL6 as a biomarker for diagnosing and predicting progression of interstitial lung disease in ANCA-associated vasculitis [0.03%]
抗中性粒细胞胞浆抗体相关性血管炎间质性肺疾病的诊断及预后标志物CXCL6的研究
Wei Li,Weiwei Hao,Wenjun Cao et al.
Wei Li et al.
Objective: To investigate serum CXCL6 as a biomarker at diagnosis and predict progression of interstitial lung disease (ILD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ...
Accelerometer-derived physical activity patterns and risk of incident gout: a prospective cohort study of 97,387 UK Biobank participants [0.03%]
基于加速度计的运动模式与痛风风险的关系：一项关于97387名英国生物银行参与者的研究
Qiang Wang,Yueming Liu,Bin Zhu
Qiang Wang
Background: The influence of physical activity (PA) patterns on gout risk is unclear. We investigated the associations of accelerometer-derived PA patterns, specifically regularly active (RA) and weekend warrior (WW), wit...
Differential complement pathways and components in the clinical spectrum of systemic lupus erythematosus [0.03%]
系统性红斑狼疮临床分型中的补体差异路径及成分
Haijun Ma,Qingfeng Yin,Huifang Li et al.
Haijun Ma et al.
Objectives: The precise contributions of the classical (CP), lectin (LP), and alternative (AP) pathways to systemic lupus erythematosus (SLE) remain incompletely understood. This study aimed to comprehensively investigate...
Soquelitinib inhibition of IL-2-inducible T cell kinase ameliorates lung damage in murine models of systemic sclerosis [0.03%]
索奎利替尼通过抑制IL-2诱导的T细胞激酶改善系统性硬化症小鼠模型的肺损伤
Gonçalo Boleto,Anne Cauvet,Christophe Guignabert et al.
Gonçalo Boleto et al.
Background: Interleukin-2-inducible T cell kinase (ITK) is a tyrosine kinase involved in T cell activation, differentiation, and receptor signaling. Soquelitinib (SQL) is a selective, covalent inhibitor of ITK. The abnorm...
Explainable machine learning for orthopedic decision-making: predicting functional outcomes of total hip replacement from gait biomechanics [0.03%]
面向骨科决策的可解释机器学习：从步态生物力学预测全髋置换的功能预后
Bernd J Stetter,Jonas Dully,Felix Stief et al.
Bernd J Stetter et al.
This study aimed to identify subpopulations of patients with hip osteoarthritis who exhibit distinct adaptations in gait biomechanics, and to evaluate subpopulation-specific effects of total hip replacement on gait biomechanics. Three datas...
Novel insights into the biology of childhood arthritis- lessons learned from the synovium [0.03%]
儿童关节炎发病机制的新见解—滑膜组织研究的启示
Chrissy Bolton,Margaret H Chang
Chrissy Bolton
Chronic inflammatory arthritis of childhood, known as juvenile idiopathic arthritis (JIA), exhibits distinct and shared features with adult-onset disease. Recent advances in minimally invasive synovial biopsy, high resolution imaging and se...