Transcriptome analysis unveils Th1 cell cycle signature as a distinctive feature of mixed connective tissue disease [0.03%]
转录组分析揭示Th1细胞周期特征为重叠性结缔组织病的显著标志
Yuichi Suwa,Yasuo Nagafuchi,Saeko Yamada et al.
Yuichi Suwa et al.
Objectives: Mixed connective tissue disease (MCTD) is characterized by positivity for anti-U1-RNP antibodies and a combination of symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and inflammatory ...
Maternal-fetal outcomes and therapeutic strategies in pregnancies complicated by Takayasu arteritis: a comprehensive analysis [0.03%]
塔克曜氏动脉炎妊娠并发症的母胎结局及治疗策略：全面分析
Wangjin Chen,Ruilian Xie,Yushuang Xiao et al.
Wangjin Chen et al.
Objective: To evaluate maternal-fetal outcomes and therapeutic efficacy in Takayasu arteritis (TA)-complicated pregnancies through integrated retrospective analysis and meta-analytic synthesis. ...
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases [0.03%]
优化衍生物EPI-X4靶向CXCL12 / CXCR4通路可保持软骨细胞功能并为风湿病提供新的治疗途径
Leonie Ruths,Hannah de Hesselle,Felix Haußner et al.
Leonie Ruths et al.
Background: The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous. However, it is assumed that the CXCL12...
From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis [0.03%]
从自身免疫性炎症到恶性肿瘤：风湿性关节炎-鳞状细胞肺癌轴的因果遗传证据
Jianbin Li,Suiran Li,Yuxiu Ka et al.
Jianbin Li et al.
Background: The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, and previou...
Clinical and molecular links between chronic systemic inflammation and structural damage in axial spondyloarthritis [0.03%]
慢性系统性炎症与轴向脊柱关节炎结构损伤的临床及分子关联研究
Laura Cuesta-López,Iván Arias-de la Rosa,María Lourdes Ladehesa-Pineda et al.
Laura Cuesta-López et al.
Efficacy of Risankizumab across distinct PsA phenotypes identified with machine learning analytics using data from biologic DMARD-Naïve patients in two phase 3 clinical trials [0.03%]
利塞珠单抗治疗生物改善病情抗风湿药初治的银屑病关节炎患者：两项3期临床试验中利用机器学习分析识别的不同亚型患者的疗效
Laure Gossec,Andra Balanescu,Maria Antonietta D&#x;Agostino et al.
Laure Gossec et al.
Background: The development of personalized approaches in psoriatic arthritis (PsA) is challenging due to unclear patient phenotypes and trajectories. Machine learning (ML) could help to identify homogeneous patient group...
Effects of paternal preconception exposure to conventional and biologic DMARDs on newborn outcomes [0.03%]
父亲孕前接触常规及生物改善病情抗风湿药对新生儿结局的影响
Yu-Hsuan Joni Shao,Tzu-Tung Kuo,Wei-Hao Wang et al.
Yu-Hsuan Joni Shao et al.
Background: Birth outcomes associated with conventional synthetic and biologic disease-modifying antirheumatic drugs (csDMARDs, bDMARDs and tsDMARDs) in fathers with autoimmune rheumatic diseases (AIRDs) is not well under...
Bedside needle arthroscopy for native joint bacterial arthritis in a real-world clinical practice setting: a prospective cohort study [0.03%]
真实世界临床实践中床旁针孔镜在原发关节细菌性关节炎治疗中的应用：前瞻性队列研究
Alex B Walinga,Stein J Janssen,Tobias Stornebrink et al.
Alex B Walinga et al.
Background: Bacterial (i.e., septic) arthritis requires prompt source control, including drainage of the infected synovial fluid, often through arthrocentesis (needle aspiration) or surgical intervention, in combination w...
Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury [0.03%]
内侧半月板损伤后补体因子D（adipsin）介导压力痛觉过敏现象
Priscilla M Tjandra,Bethany A Andoko,Jooyoung A Kim et al.
Priscilla M Tjandra et al.
Background: Osteoarthritis (OA) is the leading cause of pain worldwide. However, clinical discordance between pain and cartilage damage presents challenges in determining the mechanisms of OA pain, thus creating a need fo...
Urinary acetylated protein as a biomarker of lupus nephritis: a prospective cohort study [0.03%]
乙酰化蛋白作为狼疮性肾炎生物标志物的前瞻性队列研究
Yeo-Jin Lee,Eun-Ju Lee,Kyunggon Kim et al.
Yeo-Jin Lee et al.