The development of a clinical prediction model for response to methotrexate, tofacitinib, and etanercept in patients with Psoriatic Arthritis [0.03%]
开发用于预测银屑病关节炎患者甲氨蝶呤、托法替尼和英夫利昔单抗治疗反应的临床预测模型的发展
F T Perton,M L M Bentvelzen,S Fadaei et al.
F T Perton et al.
Background: The aim of this study was to use clinical data to develop a prediction model for treatment response, comparing tofacitinib to methotrexate or etanercept in individual patients with Psoriatic Arthritis. ...
Randomized Controlled Trial
Arthritis research & therapy. 2025 Oct 27;27(1):197. DOI:10.1186/s13075-025-03660-2 2025
Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative [0.03%]
膝关节持续痛和间歇痛与T2值及软骨厚度的关系：来自骨关节炎计划的数据
Maximilian T Löffler,Gabby B Joseph,John A Lynch et al.
Maximilian T Löffler et al.
Gut inflammation is associated with structural spinal damage in axial spondyloarthritis - results from the observational SPARTAKUS cohort [0.03%]
脊柱结构性损害与轴性脊柱关节炎患者的肠道炎症有关——SPARTAKUS观察队列研究结果
Johan Karlsson Wallman,Elisabeth Mogard,Jonas Sagard et al.
Johan Karlsson Wallman et al.
Background: In axial spondyloarthritis (axSpA), 5-10% of patients have comorbid inflammatory bowel disease (IBD). Beyond that, 50-60% display histologic inflammation in ileum/colon biopsies, and fecal calprotectin (F-calp...
Observational Study
Arthritis research & therapy. 2025 Oct 21;27(1):195. DOI:10.1186/s13075-025-03663-z 2025
A DNA methylation-based algorithm for diagnosing rheumatoid arthritis [0.03%]
一种基于DNA甲基化的诊断类风湿性关节炎的算法
Espen Riskedal,Astanand Jugessur,Silje Watterdal Syversen et al.
Espen Riskedal et al.
Background: Rheumatoid arthritis (RA), particularly seronegative disease, is difficult to diagnose early, which can delay treatment initiation. This study aims to develop a binary DNA methylation (DNAm)-based algorithm to...
Efficacy and safety of rituximab versus intravenous cyclophosphamide for systemic sclerosis-associated interstitial lung disease: a retrospective cohort study [0.03%]
利妥昔单抗与静脉注射环磷酰胺治疗系统性硬化症相关间质性肺病的疗效和安全性：回顾性队列研究
Rioko Hiura,Masahiro Ayano,Ayumi Uchino et al.
Rioko Hiura et al.
Background: The efficacy of rituximab (RTX) for the treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD) has not been fully established. This study compared the efficacy and safety of RTX and int...
Comparative Study
Arthritis research & therapy. 2025 Oct 17;27(1):193. DOI:10.1186/s13075-025-03654-0 2025
Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis [0.03%]
Foxp3+ Treg细胞通过β2-肾上腺素受体/β-arrestin 2/ERK信号减轻实验性类风湿关节炎炎症反应及症状
Yan Liu,Xiao-Qin Wang,Jian-Hua Lu et al.
Yan Liu et al.
Background: β2-adrenergic receptor (β2-AR) is widely expressed on immune cells, including T cells and it has a non-canonical signaling pathway, which is β2-AR-β-arrestin 2 (β-Arr2)-extracellular signal-regulated kina...
"I'm in pain, and I'm not faking it": A qualitative exploration of the reactions of youth with juvenile idiopathic arthritis and their caregivers to pain-related stigma [0.03%]
“我有疼痛，且不是假装的”: 关于青年 Still 性关节炎患者及其监护人对与疼痛相关污名反应的定性研究
Blair N Irish,Christine T Chambers,Justine Dol et al.
Blair N Irish et al.
Background: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory condition often marked by pain in childhood. JIA pain has a variable course and often lacks any visible signs. As such, youth with JIA can experien...
Multimodal brain structural and functional analysis in systemic lupus erythematosus patients without overt neuropsychiatric manifestations: associations with disease duration, organ damage, and neurocognitive function [0.03%]
无明显神经精神症状的系统性红斑狼疮患者的多模态脑结构和功能分析：与病程、器官损害和神经认知功能的关系
Jeonghwan Lee,Ji Hyoun Kim,Chi-Hoon Choi et al.
Jeonghwan Lee et al.
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that often affects the central nervous system (CNS), leading to structural and functional brain alterations. Although neuroimaging studies hav...
Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease [0.03%]
单细胞测序揭示了抗MDA5抗体阳性皮肌炎中快速进展性间质性肺病的外周免疫反应的差异
Chenghua Weng,Enzhuo Liu,Hui Zheng et al.
Chenghua Weng et al.
Background: Anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis (MDA5+ DM) is an autoimmune disease related to rapidly progressive interstitial lung disease (RPILD) with high mortality. Ho...
Real-world sex differences in treatment persistence and reasons for discontinuation in psoriatic arthritis patients: results from the German RABBIT-SpA register [0.03%]
德国RABBIT-脊柱关节炎登记处的真实世界中银屑病性关节炎患者的治疗持续时间的性别差异及停药原因分析结果
Lisa Lindner,Anja Weiß,Andreas Reich et al.
Lisa Lindner et al.
Background: In psoriatic arthritis (PsA), growing evidence indicates sex-specific differences regarding clinical manifestation and treatment outcomes. Research has highlighted that females may be less likely to achieve tr...