Association of Primary Sclerosing Cholangitis With HLA-C*07:02 in a Japanese Population [0.03%]
HLA-C*07:02与原发性硬化性胆管炎在日本人群中的关联研究
Tatsuya Okamoto,Hideaki Okajima,Masashi Kadohisa et al.
Tatsuya Okamoto et al.
Background and aims: Primary sclerosing cholangitis (PSC) is a progressive, refractory liver disease often requiring liver transplantation (LT). The association between the disease onset and specific human leukocyte antig...
Limitations of Guideline-Recommended Risk Stratification in Identifying MASLD Patients for Novel Drug Treatments [0.03%]
指南推荐的危险分层在识别适合新型药物治疗的MASLD患者中的局限性
Martin Franck,Katharina John,Monika Rau et al.
Martin Franck et al.
Current guidelines recommend FIB-4 and transient elastography for non-invasive risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD). These tests can predict the presence or absence of advanced fibrosis, bu...
Elsie Ennin,Niharika Mallepally,Jennifer L Dodge et al.
Elsie Ennin et al.
Navigating the Hepatic Immune Landscape With Fine Needle Aspiration of the Liver-An Emerging Technique [0.03%]
肝细针抽吸检测技术在肝脏免疫景观中的应用及前景
Kate Diana Lynch,Fabiola Curion,Hing-Yuen Yeung et al.
Kate Diana Lynch et al.
Background and aims: Hepatic immune cell analysis is critical for understanding chronic inflammatory liver diseases, such as primary sclerosing cholangitis (PSC) and steatotic liver disease. However, liver immunoprofiling...
The Cannabinoid System as a Potential Novel Target for Alcohol-Associated Liver Disease: A Propensity-Matched Cohort Study [0.03%]
大麻素系统作为酒精相关性肝病潜在新靶点的一项倾向匹配队列研究
Butros Fakhoury,Vinay Jahagirdar,Kaanthi Rama et al.
Butros Fakhoury et al.
Background: Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality, yet effective therapeutic options remain limited. Preclinical data suggest that modulation of the hepatic end...
A Phase 2a Trial of Myeloperoxidase Inhibitor Mitiperstat in Non-Cirrhotic Metabolic Dysfunction-Associated Steatohepatitis [0.03%]
甲氧基多巴酚丁胺在非肝硬化代谢紊乱相关性脂肪肝病患者中的IIa期临床试验
Javier Armisen,Armando Flor,John Eriksson et al.
Javier Armisen et al.
Background and aims: Neutrophil myeloperoxidase is involved in different inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH). Mitiperstat is a highly potent myeloperoxidase inhibitor. ...
Reconsidering Imaging Endpoints and VEGF Biomarkers in SUN-CK: Towards Biologically Informed Trials [0.03%]
基于SUN-CK的血管生成因子生物标志物和影像学终点的再思考：推动以生物学为基础的临床试验
Ke-Yi Xu,Ming-Yu Wan,Jian Ruan
Ke-Yi Xu
Impact of Handling Perception and Language Barriers on Virologic Response to Daily Subcutaneous Bulevirtide in Hepatitis D [0.03%]
处理 handling 语言障碍对每日皮下注射 buleviridine治疗丁型肝炎病毒学反应的影响
Toni Herta,Christopher Dietz-Fricke,Münevver Demir et al.
Toni Herta et al.
Background: Bulevirtide (BLV) is the only approved therapy for chronic hepatitis D (CHD) and compensated liver disease. Daily subcutaneous injection and the need for refrigeration may pose challenges, especially in patien...
Metabolic Reprogramming and CD8+ T-Cell Exhaustion During Chronic HBV Infection [0.03%]
慢性HBV感染期间代谢重塑与CD8⁺ T细胞衰竭
Haohao Li,Weiwei Mu,Alison Zhao et al.
Haohao Li et al.
HBV is an enveloped DNA virus that exclusively infects hepatocytes of humans and some non-human primates. During its viral life cycle, HBV and its structural components can directly regulate the metabolism of hepatocytes, which may reshape ...