Catecholamines Activate a Tumour Progression Program in Differentiated Tumour Hepatocytes [0.03%]
儿茶酚胺激活分化肿瘤肝细胞的肿瘤进展程序
Elise Lelou,Claudine Rauch,Hélène Dubois-Pot-Schneider et al.
Elise Lelou et al.
Background and aims: The sympathetic nervous system is involved in the progression and aggressiveness of several cancers, including hepatocellular carcinoma (HCC). However, the specific effects of sympathetic innervation ...
Beyond GLP-1R: Dynamic Glucagon Receptor Family Signalling May Determine Antifibrotic Responses to Incretin-Based Therapies [0.03%]
GLP-1受体之外：动态的胰高血糖素受体家族信号可能决定了基于肠促胰素疗法的抗纤维化反应
María Andrés-Rozas,Sergi Guixé-Muntet,Jordi Gracia-Sancho
María Andrés-Rozas
Viscoelastic Tests in Cirrhotic Patients Undergoing Invasive Procedures: A Systematic Review and Meta-Analysis of RCTs [0.03%]
肝硬化患者有创操作前血小板功能检查的系统评价和 meta 分析
Andrea Boccatonda,Elena Campello,Angela Napolitano et al.
Andrea Boccatonda et al.
Background and aims: Bleeding risk in cirrhotic patients undergoing invasive procedures is traditionally assessed using conventional coagulation tests, which poorly reflect the rebalanced haemostatic state of cirrhosis an...
Urinary Volatile Organic Compound Metabolites Are Associated With MASLD/MASH in Humans and Induce Steatosis in Liver Organoids [0.03%]
尿液挥发性有机化合物代谢物与人类MASLD / MASH的关联并在肝类器官中诱导脂肪变性
Laurens A van Kleef,Xincheng Li,Pengfei Li et al.
Laurens A van Kleef et al.
Background: Volatile organic compound (VOC) exposure is an environmental health concern and could, through the liver exposome, be associated with metabolic dysfunction associated steatotic liver disease (MASLD) progressio...
Hepatic and Cardiovascular Outcomes in Primary Biliary Cholangitis With Metabolic-Dysfunction Associated Steatotic Liver Disease [0.03%]
代谢功能异常相关肝脂肪变性肝病的原发性胆汁性胆管炎患者肝脏和心血管结局不良
Jarell Jie-Rae Tan,Joo Wei Ethan Quek,Sean Shao Wei Lam et al.
Jarell Jie-Rae Tan et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in patients with primary biliary cholangitis (PBC). While metabolic comorbidities are expected to worsen outcomes, ...
Microtubule-Targeting Drugs Induce Mesenchymal-Epithelial Transition in Hepatic Stellate Cells [0.03%]
微管靶向药物可诱导肝星状细胞发生间上皮转化
Hayato Urushima,Tsutomu Matsubara,Hideto Yuasa et al.
Hayato Urushima et al.
Background and aims: Liver fibrosis is a progressive pathological condition characterized by excessive extracellular matrix accumulation, primarily driven by activated hepatic stellate cells (HSCs). While molecular-based ...
Systematic Review and Meta-Analysis of Lactulose for the Prevention and Treatment of Hepatic Encephalopathy [0.03%]
乳果糖防治肝性脑病的系统评价和 meta 分析
Lauren Kasmikha,Xi Chen,Marina Serper et al.
Lauren Kasmikha et al.
Background and aims: Hepatic encephalopathy (HE) is morbid and increases mortality in cirrhosis. Lactulose is first-line therapy for HE treatment and secondary prophylaxis; however, data supporting its role in primary pre...
Adeno-Associated Virus Gene Therapy for Spinal Muscular Atrophy Induces Hepatotoxicity via Cytokine and Macrophage Activation [0.03%]
腺相关病毒基因治疗通过细胞因子和巨噬细胞活化诱发脊髓性肌萎缩症肝毒性
Aiko Sakai,Masaya Sugiyama,Masafumi Onodera et al.
Aiko Sakai et al.
Hepatotoxicity is a common and significant adverse effect associated with adeno-associated virus (AAV) gene therapy; however, the underlying mechanisms remain unknown. In this study, we demonstrated innate immune activation in two patients ...
The Changing Etiological Landscape of Liver Cancer in the Era of Metabolic Disease [0.03%]
代谢性疾病时代肝癌的病因格局变化
Xiao-Dong Zhou,Daniel Q Huang,Giada Sebastiani et al.
Xiao-Dong Zhou et al.
Enhanced Liver Fibrosis Test, FIB-4 and FibroScan: Real-World Prognostic Accuracy for MASLD in a Biopsy-Controlled Cohort [0.03%]
增强肝脏纤维化检测、FIB-4和FibroScan：在活检对照队列中对MASLD的现实世界预后准确性评估
Antonio Liguori,Francesca D&#x;Ambrosio,Giulia Angelini et al.
Antonio Liguori et al.
Background and aims: Liver fibrosis is a major determinant of liver-related events (LREs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Effective stratification based on fibrosis sever...