Trefoil Factor-3 Is a Hypoxia-Triggered Pro-Tumorigenic Factor in Hepatoblastoma [0.03%]
三叶因子3是肝母细胞瘤缺氧诱导的促肿瘤生成因子
Luz A Martínez-Pérez,M Ujue Latasa,Iker Uriarte et al.
Luz A Martínez-Pérez et al.
Background & aims: Hepatoblastoma (HB) is the most common malignant liver tumour in children. Despite improved survival in low-risk disease, outcomes for advanced or relapsed HB remain poor, emphasising the need for new t...
A Case of Severe Ibrutinib-Induced Liver Injury and Successful Transition to Acalabrutinib [0.03%]
伊布替尼致严重肝损伤一例及阿卡替尼成功转换治疗
Vera Ciornolutchii,Abdulrahman Ismaiel
Vera Ciornolutchii
Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions [0.03%]
针对LPI/GPR55轴在MAFLD和MASH中的靶向治疗：新见解、治疗策略及未来方向
Jerome Lian,Ricky R Lareu,Mohan Patil et al.
Jerome Lian et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD), recently redefined from non-alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L-α-lysophosphatidylinositol/...
Tofacitinib Rescue for Refractory Drug-Induced Liver Injury With Severe DRESS: A Prospective Proof-of-Concept Study [0.03%]
托法替尼治疗难治性药物诱导的肝损伤伴严重药物反应综合征的概念验证研究
Jingyan Gu,Yuan Wang,Xiaoyu Wang et al.
Jingyan Gu et al.
Drug-induced liver injury (DILI) with severe DRESS carries high mortality, yet rescue therapies for corticosteroid-refractory cases remain undefined. We hypothesized that JAK inhibition could reverse refractory liver injury by targeting the...
Hepatocellular Carcinoma in Egypt in the Post HCV Elimination Era: Changing Aetiology, Surveillance, and Management Pathways [0.03%]
乙肝消除后时代下埃及肝细胞癌的发病机制、监测和治疗途径的变化
Mohamed El-Kassas,Rofida Khalifa,Mohamed Kohla et al.
Mohamed El-Kassas et al.
Egypt carries one of the highest contemporary burdens of hepatocellular carcinoma (HCC) worldwide, shaped by a distinctive historical prevalence of hepatitis C virus (HCV) following parenteral anti-schistosomal therapy campaigns and now ent...
Early Adoption and Prescribing Patterns of Resmetirom: A Multi-Institutional National Analysis [0.03%]
雷美昔布早期使用及处方模式的多机构国家分析
Kate Solpari,Zane Gouda,Allysa Saggese et al.
Kate Solpari et al.
Resmetirom received FDA approval in March 2024 as the first therapy for noncirrhotic MASH with moderate-to-advanced fibrosis. This retrospective cohort study used the TriNetX Research Network to assess early prescribing patterns among 3712 ...
Defining the Contribution of Genetic Variants in MRGPRX4 With Pruritus in Paediatric Cholestasis: Evidence From Case-Control Study [0.03%]
儿童胆汁淤积症病例对照研究中MRGPRX4基因变异与瘙痒关联的证据及意义分析
Minna Rodrigo,Daphne Chun-Che Chien,Ryo Kawamoto et al.
Minna Rodrigo et al.
Background and aims: Cholestatic pruritus is a debilitating symptom in paediatric liver disease with a complex and poorly understood pathogenesis. Recent evidence implicates the Mas-related G protein-coupled receptor X4 (...
Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study [0.03%]
肝移植治疗原发性硬化性胆管炎患者生存率和贿赂行为之间的关系：一项法国全国队列研究
Florian Veyre,Claire Francoz,Domitille Erard et al.
Florian Veyre et al.
Background: A significant proportion of patients presenting a primary sclerosing cholangitis (PSC) will require liver transplantation (LT). The present study aimed to investigate graft loss and patient death in a large co...
Response to Letters to the Editor Regarding 'Terlipressin for Hepatorenal Syndrome in Patients With Early-Stage Acute-On-Chronic Liver Failure' [0.03%]
特利压素治疗急性-on-慢性肝功能衰竭早期患者肝肾综合征答读者来信
Don C Rockey,Fredric Gordon,David Victor et al.
Don C Rockey et al.
An Update on Bile Acid-Regulated Signalling in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
胆汁酸调节信号在代谢功能障碍相关性肝脂肪变性疾病发病机制中的最新研究进展
Jiang-Shan Shi,Yi Wen,Lu Wang et al.
Jiang-Shan Shi et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolic disorder with rising global incidence without effective treatment. Emerging evidence highlights bile acids (BAs) as pivotal signalling molecules that mod...