Protein O-GlcNAcylation: The sweet hub in liver metabolic flexibility from a (patho)physiological perspective [0.03%]
从生理和病理生理学角度看肝脏代谢灵活性中的蛋白质O-GlcNAc酰化作用：一颗甜甜的枢纽明星分子
Ya-Jie Hu,Xu Zhang,Hong-Ming Lv et al.
Ya-Jie Hu et al.
O-GlcNAcylation is a dynamic, reversible and atypical O-glycosylation that regulates various cellular physiological processes via conformation, stabilisation, localisation, chaperone interaction or activity of target proteins. The O-GlcNAcy...
Von Willebrand factor as a predictor of mortality in acute-on-chronic liver failure: Do not throw out the baby with the bathwater [0.03%]
急性-on-慢性肝功能衰竭中血管性假血友病因子预后价值不容忽视
Ton Lisman,Bente P van den Boom,William Bernal et al.
Ton Lisman et al.
A risk prediction model for hepatocellular carcinoma in non-alcoholic fatty liver disease without cirrhosis: HCC prediction for non-cirrhotic NAFLD [0.03%]
非肝硬化的非酒精性脂肪性肝病患者肝细胞癌风险预测模型：非肝硬化型非酒精性脂肪肝的肝细胞癌预测模型
Gi-Ae Kim,Yewan Park,Shin Ju Oh et al.
Gi-Ae Kim et al.
Background & aims: Although non-alcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular carcinoma (HCC), HCC risk in non-cirrhotic NAFLD received little attention. We aimed to develop and valid...
NAFLD and NASH are obesity-independent risk factors in COVID-19: Matched real-world results from the large PINC AI™ Healthcare Database [0.03%]
基于PINC AI™医疗数据库的匹配真实世界结果：非酒精性脂肪肝和非酒精性脂肪性肝炎是独立于肥胖之外的COVID-19风险因素
Jonathan F Brozat,Fady Ntanios,Deepa Malhotra et al.
Jonathan F Brozat et al.
Background & aims: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are potential risk factors for severe pneumonia and other infections. Available data on the role of NAFLD/NASH in worse...
Targeted HBx gene editing by CRISPR/Cas9 system effectively reduces epithelial to mesenchymal transition and HBV replication in hepatoma cells [0.03%]
CRISPR/Cas9系统介导的HBx基因编辑可有效抑制肝癌细胞上皮间质转化及乙肝病毒复制
Preety Rawal,Dinesh Mani Tripathi,Hamed Hemati et al.
Preety Rawal et al.
Background and aims: Hepatitis B virus X protein (HBx) play a key role in pathogenesis of HBV-induced hepatocellular carcinoma (HCC) by promoting epithelial to mesenchymal transition (EMT). In this study, we hypothesized ...
The role of HBIG in real life for patients undergoing liver transplantation due to HDV-related cirrhosis [0.03%]
HBIG在HDV相关肝硬化行肝移植患者中的作用探讨
Sergio Rodríguez-Tajes,María García-Eliz,Arantxa Caballero Marcos et al.
Sergio Rodríguez-Tajes et al.
Recommended post-liver transplant (LT) prophylaxis in patients with hepatitis delta includes a nucleos(t)ide analogue (NA) and anti-hepatitis B immunoglobulin (HBIG) indefinitely. We analysed the use of HBIG in real-life clinical practice a...
Determinants of worse liver-related outcome according to HDV infection among HBsAg positive persons living with HIV: Data from the ICONA cohort [0.03%]
HIV阳性HBsAg阳性人群中HDV感染导致更差肝脏转归的影响因素：来自ICONA队列的数据分析
Antonella d&#x;Arminio Monforte,Alessandro Tavelli,Romina Salpini et al.
Antonella d&#x;Arminio Monforte et al.
Objectives: We aimed to study hepatitis D virus (HDV) prevalence and risk of progression to severe liver-related events (SLRE) in HBsAg positive people living with HIV (PLWH) in Italy; role of HDV-RNA copy levels, HCV coi...
Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1) [0.03%]
高迁移率族蛋白B1（HMGB1）介导的铁蛋白吞噬促进甲氨蝶呤诱导的肝毒性中的铁死亡作用
Chengbo Wang,Maodong Leng,Cong Ding et al.
Chengbo Wang et al.
Background and aim: Hepatotoxicity is a well-defined reaction to methotrexate (MTX), a drug commonly used for the treatment of rheumatoid arthritis and various tumours. We sought to elucidate the mechanism underlying MTX-...
How best to combine liver transplantation and bariatric surgery?-Results from a global, web-based survey [0.03%]
如何将肝移植与代谢手术最佳地结合在一起？-全球网络调查结果
Jeannette Widmer,Janina Eden,Fariba Abbassi et al.
Jeannette Widmer et al.
Background and aims: Obesity is a growing healthcare challenge worldwide and a significant risk factor for liver failure as seen with non-alcoholic steatohepatitis (NASH). Combining metabolic-bariatric surgery (MBS) with ...
Persistent pruritus associated with worse quality of life in patients with chronic hepatitis [0.03%]
慢性肝炎患者持续性瘙痒与较差的生活质量有关
Mei Lu,Loralee B Rupp,Christina Melkonian et al.
Mei Lu et al.
Introduction: Prevalence and severity of pruritus among US patients with chronic hepatitis B and C (HBV, HCV) are not well-documented. Chronic Hepatitis Cohort Study (CHeCS) patients were surveyed to examine pruritus prev...