Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation [0.03%]
ceramide合成酶同源物Tlc4通过其高尔基体易位维持核膜完整性
Yasuhiro Hirano,Yusuke Ohno,Yoshino Kubota et al.
Yasuhiro Hirano et al.
Maintaining the integrity of the nuclear envelope (NE) is essential for preventing genomic DNA damage. Recent studies have shown that enzymes that catalyze lipid synthesis are involved in NE maintenance, but the underlying mechanism remains...
Rab GTPase regulation of phagosome-lysosome fusion is bypassed in the presence of micromolar Ca2 [0.03%]
微摩尔级Ca2+的存在可绕过由Rab GTP酶介导的吞噬体和溶酶体融合调节现象
Julia Becker,Ariane Schleinitz,Christina Hermsen et al.
Julia Becker et al.
Several ATP- and cytosol-dependent fusion processes between membranes of the endocytic and exocytic pathways have been biochemically reconstituted. Here, we present a phagosome-lysosome fusion reaction that is driven by micromolar concentra...
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria [0.03%]
UbiB家族成员Cqd1在线粒体中形成一种新的膜接触位点
Siavash Khosravi,Xenia Chelius,Ann-Katrin Unger et al.
Siavash Khosravi et al.
Mitochondria are essential organelles of eukaryotic cells and are characterized by their unique and complex membrane system. They are confined from the cytosol by an envelope consisting of two membranes. Signals, metabolites, proteins and l...
Brian K Haarer,Morgan L Pimm,Ebbing P de Jong et al.
Brian K Haarer et al.
Biochemical studies of human actin and its binding partners rely heavily on abundant and easily purified α-actin from skeletal muscle. Therefore, muscle actin has been used to evaluate and determine the activities of most actin regulatory ...
Helen L Zenner,Seema Grewal
Helen L Zenner
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming [0.03%]
通过细胞外囊泡重新编程可以防止炎性巨噬细胞向肝细胞发出信号
Priyanka Ghosh,Kyo Sasaki,Isabel Aranzazu Pulido Ruiz et al.
Priyanka Ghosh et al.
Macrophage-derived extracellular vesicles (EVs) play key roles in intercellular communication. Within the liver, they have been linked to several inflammatory diseases including nonalcoholic fatty liver disease (NAFLD). In this study, we fo...
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus [0.03%]
海马中调控棕榈酰化和脱棕榈酰化的蛋白质修饰机制的活动依赖性变化
Danya Abazari,Angela R Wild,Tian Qiu et al.
Danya Abazari et al.
Activity-induced changes in protein palmitoylation can regulate the plasticity of synaptic connections, critically impacting learning and memory. Palmitoylation is a reversible post-translational modification regulated by both palmitoyl-acy...
Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner [0.03%]
CDC42通过依赖PAK1的机制阻止细胞分裂末期RHO1过早激活
Udo N Onwubiko,Dhanya Kalathil,Emma Koory et al.
Udo N Onwubiko et al.
During cytokinesis, a series of coordinated events partition a dividing cell. Accurate regulation of cytokinesis is essential for proliferation and genome integrity. In fission yeast, these coordinated events ensure that the actomyosin ring...
Genetically encoded imaging tools for investigating cell dynamics at a glance [0.03%]
一目了然的基因编码成像工具用于研究细胞动力学
Méghane Sittewelle,Nuria Ferrandiz,Mary Fesenko et al.
Méghane Sittewelle et al.
The biology of a cell is the sum of many highly dynamic processes, each orchestrated by a plethora of proteins and other molecules. Microscopy is an invaluable approach to spatially and temporally dissect the molecular details of these proc...
Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia [0.03%]
Na+-HCO3-同向转运蛋白NBCn1在质膜、中心体、纺锤体和原纤毛的动态定位
Marc Severin,Emma Lind Pedersen,Magnus Thane Borre et al.
Marc Severin et al.
Finely tuned regulation of transport protein localization is vital for epithelial function. The Na+-HCO3- co-transporter NBCn1 (also known as SLC4A7) is a key contributor to epithelial pH homeostasis, yet the regulation of its subcellular l...