Reinterpreting the effects of α-tubulin K40 acetylation on microtubule stability and cellular functions [0.03%]
α-微管蛋白K40乙酰化对微管稳定性和细胞功能影响的再解读
Yu-Ming Lu
Yu-Ming Lu
Acetylation of α-tubulin at lysine 40 (K40) has been studied in many model organisms for decades, mainly by manipulating levels of deacetylase and acetyltransferase enzymes, such as the α-tubulin acetyltransferase MEC-17 (also known as AT...
Somatic mutations in IRE1α regulate keratinocyte migration and survival by differentially activating Rho GTPases [0.03%]
IRE1α的体细胞性突变通过差异激活Rho GTP酶调节角质形成细胞迁移和存活
Saie Mogre,Lily Robinson,Komal Sethia et al.
Saie Mogre et al.
IRE1α is an Endoplasmic Reticulum (ER) transmembrane protein with cytoplasmic kinase and endoribonuclease (RNase) domains. Under ER stress, IRE1α can splice Xbp1 mRNA enabling translation of this Unfolded Protein Response transcription fa...
Syntaxin-2 balances phagocytic uptake and phagolysosomal clearance in macrophages [0.03%]
巨噬细胞中syntaxin-2平衡吞噬作用和吞噬溶酶体清除作用
Suman Samanta,Abhrajyoti Nandi,Rupak Datta et al.
Suman Samanta et al.
Phagocytosis engulfs receptor-bound particles within phagosomes that mature into acidic, hydrolase-enriched phagolysosomes for content degradation. While an essential process for host defense and homeostasis, defective or uncontrolled phago...
MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells [0.03%]
MitoRUSH作为一种研究复杂I缺陷细胞中线粒体导入效率的工具
Michal Wasilewski,Karthik Mohanraj,Maciej Zakrzewski et al.
Michal Wasilewski et al.
Most mitochondrial proteins are imported through the actions of the presequence translocase of the inner membrane, the TIM23 complex, which requires energy in the form of the electrochemical potential of the inner membrane and ATP. Conversi...
Mitochondrial topoisomerases, nucleoid architecture and mtDNA repair in human disease [0.03%]
线粒体拓扑异构酶、基因组结构与人类疾病中的mtDNA修复
Sangheeta Bhattacharjee,Benu Brata Das
Sangheeta Bhattacharjee
DNA topoisomerases are essential for maintaining DNA topology, gene expression and the accurate transmission of genetic information. Mitochondria possess circular DNA (mtDNA), which, unlike nuclear chromosomes, lacks protective histones and...
Functional residuomics - analyzing how missense mutations impact cellular systems [0.03%]
功能性残留组学分析错义突变如何影响细胞系统
Guangshuo Ou
Guangshuo Ou
Functional residuomics explores how individual amino acid residues influence protein function, interactions and cellular homeostasis, shifting the focus from gene-level mutations to residue-level alterations. Unlike gene-centric approaches,...
Human disease variants of KATNIP fail to support CILK1 activation and control of primary cilia [0.03%]
人类疾病的KATNIP变异不能支持CILK1的激活和原生纤毛的作用
Evan H Carpenter,Cheuk Ying Chu,Ana Limerick et al.
Evan H Carpenter et al.
Pathogenic variants in KATNIP (katanin-interacting protein) are linked to Joubert syndrome, a prototypical ciliopathy. KATNIP is a scaffold protein that binds and potentiates CILK1 (ciliogenesis-associated kinase 1) activation and function ...
Transcriptional adaptation after deletion of Cdc42 in primary T cells [0.03%]
原代T细胞中删除Cdc42后的转录适应性变化
Adam M Rochussen,Claire Y Ma,Gillian M Griffiths
Adam M Rochussen
Cdc42 is a Rho family GTPase known for its central role in cell polarity and cytoskeletal regulation. To understand the role of Cdc42 in polarised secretion from cytotoxic T lymphocytes (CTLs) we used CRISPR/Cas9 gene deletion. While Cdc42-...
The adhesion plaque mediates fluid discharge and duplication of the contractile vacuole complex in Trypanosoma cruzi [0.03%]
阿德希尔斑片介导了克氏锥虫细胞收缩体的液体排出及收缩体复杂结构的复制
Ingrid Augusto,Wendell Girard Dias,Alejandra Schoijet et al.
Ingrid Augusto et al.
This work explores the intricate process of osmoregulation in Trypanosoma cruzi, the causative agent of Chagas disease, with a specific focus on the mechanisms of fluid discharge by the Contractile Vacuole Complex (CVC) and the role of the ...
RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells [0.03%]
RHOA在缺氧暴露的胃上皮细胞中调节线粒体重塑和细胞运动性的作用机制研究
Aranya Pal,Prabin Bawali,Abhisek Brahma et al.
Aranya Pal et al.
Mitochondrial appearance distinctively reflects cellular stress. Hypoxia, one of the most fundamental stressors, drives tumor progression, impacting mitochondrial structure and function. RAS homolog family member A (RHOA), a key regulator o...