The fungal virulence factor PefD activates sleep neurons of Caenorhabditis elegans [0.03%]
昆虫病原真菌通过激活秀丽隐杆线虫的睡眠神经元来捕食线虫
Anna-Lena Klemke,Xiaodi Hu,Pietrina Steudel et al.
Anna-Lena Klemke et al.
Nematode-trapping fungi (NTF) such as Arthrobotrys flagrans employ sophisticated strategies to immobilize and digest their prey. A critical, yet poorly understood, step in this interaction is the induction of prey paralysis following captur...
Conditional deletion of human STN1 leads to telomere dysfunction, genome instability and proliferation defects [0.03%]
条件性敲除人STN1导致端粒功能障碍、基因组不稳定性及增殖缺陷
Jaclyn S Holbrooks,Colin A Loveless,Kennedy A Vogler et al.
Jaclyn S Holbrooks et al.
CTC1-STN1-TEN1 (CST) is a heterotrimeric, RPA-like complex that binds single-stranded DNA, stimulates DNA polymerase α-primase, and functions in several genome maintenance pathways, including telomere maintenance and DNA replication and re...
Swastik Kar,Yaniv M Elkouby
Swastik Kar
The Balbiani body (Bb) is a conserved membraneless compartment that assembles in early oocytes across animal species and is required for oocyte growth, polarity and developmental competence. It is composed of RNA-protein complexes and enric...
Multiple glycoforms of TrkA interact with N-cadherin during trigeminal ganglion neurodevelopment [0.03%]
三叉神经感觉神经元中多种TrkA糖型与N-钙黏着蛋白的相互作用
Caroline A Halmi,Lisa A Taneyhill
Caroline A Halmi
The trigeminal ganglion is a sensory structure derived from neural crest and placode cells, leading to a heterogeneous neuronal population that transmits somatosensory information to the brain. Proper trigeminal ganglion development relies,...
SILAC-based discovery of a broad range of proteins that can be posttranslationally glutamylated or glycylated [0.03%]
基于 SILAC 的发现可被进行蛋白酶处理的谷氨酰化或甘氨酰化的广泛蛋白质种类
Sucheta Dey,Sanjana Mullick,Veronique Henriot et al.
Sucheta Dey et al.
The posttranslational modifications (PTMs) glutamylation and glycylation are primarily associated with tubulins and microtubule regulation, while their broader functional scope is largely underexplored. It is known that both PTMs also occur...
A screening pipeline to characterize stress-induced enzymes uncovers a cellular function for the poorly characterized alcohol dehydrogenase Bdh2 [0.03%]
一种鉴定压力诱导产生的酶的筛选途径揭秘了作用尚不清楚的乙醇脱氢酶Bdh2的细胞功能
Dunya Edilbi,Rosario Valenti,Benjamin Dubreuil et al.
Dunya Edilbi et al.
Cells possess intricate metabolic networks comprised of hundreds of enzymes. Despite extensive research, many of these enzymes remain uncharacterized. Identifying the function of these enzymes is crucial for advancing our understanding of c...
A RhoGEF activates EhRacM to selectively promote motility without affecting macropinocytosis in Entamoeba histolytica [0.03%]
EhSGST5通过活化EhRacM促进运动性但不影响巨胞饮作用
Misato Shimoyama,Kumiko Nakada-Tsukui,Tomoyoshi Nozaki
Misato Shimoyama
Rho guanine nucleotide-exchange factors (RhoGEFs) activate Rho/Rac small GTPases, orchestrating cellular processes, such as actin remodeling, endocytosis, and migration. In the protozoan parasite Entamoeba histolytica, the causative agent o...
Understanding the molecular components of mechanically evoked currents in the Merkel cell line MCC13 [0.03%]
了解机械刺激诱发的麦克尔细胞系MCC13电流的分子组成
Zijing Zhou,Sonia Paz-López,Lennart Kuck et al.
Zijing Zhou et al.
Merkel cells are epithelial cells involved in the discrimination of light touch. Situated in the skin, these specialised cells decode mechanical cues through the mechanosensitive ion channel PIEZO2. Merkel cell carcinoma lines have been wid...
Douglas R Green
Douglas R Green
The fact that cells die during development, metamorphosis and tissue homeostasis was recognized well over a century ago. However, aside from noting and classifying such cell death events, research into the mechanisms of regulated cell death...
Glucocorticoids regulate small extracellular vesicle release via activation of nSMase2 [0.03%]
糖皮质激素通过激活nSMase2调节微小胞外囊泡的释放
Mia R Burke,Clarissa L Waites
Mia R Burke
Glucocorticoid (GC) steroid hormones mediate the stress response, which requires dynamic communication between brain regions to enable an organism to react to and overcome perceived stressors. While many effects of GCs on the brain have bee...