Tetraploid Caenorhabditis elegans embryos exhibit enhanced tolerance to osmotic stress [0.03%]
四倍体秀丽隐杆线虫胚胎表现出对渗透压胁迫的耐受性增强
Yuiko Oyama,Misako Ohama,Namu Yamada et al.
Yuiko Oyama et al.
Polyploidy is a widespread phenomenon in development and evolution and is frequently associated with altered cellular physiology and developmental robustness. However, how genome doubling influences an embryonic robustness to environmental ...
Mask modulates Toll signaling by regulating the levels of Cactus in Drosophila [0.03%]
Mask通过调节果蝇中Cactus的水平来调控Toll信号通路
Bappi Sarkar,Mousumi Mutsuddi,Ashim Mukherjee
Bappi Sarkar
Innate immunity serves as the first line of defense against pathogens, requiring precise regulation to maintain immune homeostasis. The Toll signaling pathway is a central regulator of immune responses in both Drosophila and mammals, with i...
The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A [0.03%]
高尔基体囊泡衔接蛋白p115/USO1可以直接与内质网出芽位点组织者Sec16A结合
Igor Yakunin,Alison K Gillingham,Conceição Pereira et al.
Igor Yakunin et al.
Newly made secretory and membrane proteins exit the endoplasmic reticulum (ER) in COPII vesicles that form at specialised ER exit sites. These exit sites are typically near to the early Golgi compartments that receive these vesicles. A key ...
Radical diffusion, not lifetime, determines the range of Peroxidase-based proximity labelling [0.03%]
过氧化物酶介导的邻近标记的标记范围由分子扩散决定而非底物半衰期决定
Samarpita Sen,Daniel St Johnston
Samarpita Sen
Proximity-labelling offers a powerful strategy for mapping the molecular composition in the vicinity of a protein of interest. Here, we employed APEX2- and HRP-mediated biotinylation in the Drosophila follicular epithelium to analyse the ap...
Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate [0.03%]
肌动蛋白结合蛋白Profilin 1依赖性调节细胞磷脂酰肌醇(4,5)二磷酸的分子机制
Andrew Orenberg,Michael Chirumbolo,Ian Eder et al.
Andrew Orenberg et al.
Phosphatidylinositol (4,5)-bisphosphate (PIP2), the most abundant cellular poly-phosphoinositide (PPI) class of phospholipid, is a central plasma membrane (PM)-associated signaling hub that controls many cellular processes. In this study, w...
Progerin cross-linking stiffens the nucleus and impairs mechanosensation in Hutchinson-Gilford progeria syndrome [0.03%]
质核交联可使细胞核僵硬并损害霍奇金-吉尔福德进行性早老症患者的细胞机械感受功能
Luv Kishore Srivastava,Ajinkya Ghagre,Ioannidis Duchastel-Vassaramva et al.
Luv Kishore Srivastava et al.
Nuclear mechanosensation enables cells to detect and respond to mechanical cues through deformation governed by lamina and chromatin stiffness. In Hutchinson-Gilford Progeria Syndrome (HGPS), whether nuclear stiffening arises from progerin ...
The fungal virulence factor PefD activates sleep neurons of Caenorhabditis elegans [0.03%]
昆虫病原真菌通过激活秀丽隐杆线虫的睡眠神经元来捕食线虫
Anna-Lena Klemke,Xiaodi Hu,Pietrina Steudel et al.
Anna-Lena Klemke et al.
Nematode-trapping fungi (NTF) such as Arthrobotrys flagrans employ sophisticated strategies to immobilize and digest their prey. A critical, yet poorly understood, step in this interaction is the induction of prey paralysis following captur...
Conditional deletion of human STN1 leads to telomere dysfunction, genome instability and proliferation defects [0.03%]
条件性敲除人STN1导致端粒功能障碍、基因组不稳定性及增殖缺陷
Jaclyn S Holbrooks,Colin A Loveless,Kennedy A Vogler et al.
Jaclyn S Holbrooks et al.
CTC1-STN1-TEN1 (CST) is a heterotrimeric, RPA-like complex that binds single-stranded DNA, stimulates DNA polymerase α-primase, and functions in several genome maintenance pathways, including telomere maintenance and DNA replication and re...
Swastik Kar,Yaniv M Elkouby
Swastik Kar
The Balbiani body (Bb) is a conserved membraneless compartment that assembles in early oocytes across animal species and is required for oocyte growth, polarity and developmental competence. It is composed of RNA-protein complexes and enric...
Multiple glycoforms of TrkA interact with N-cadherin during trigeminal ganglion neurodevelopment [0.03%]
三叉神经感觉神经元中多种TrkA糖型与N-钙黏着蛋白的相互作用
Caroline A Halmi,Lisa A Taneyhill
Caroline A Halmi
The trigeminal ganglion is a sensory structure derived from neural crest and placode cells, leading to a heterogeneous neuronal population that transmits somatosensory information to the brain. Proper trigeminal ganglion development relies,...