The kinetochore component HCP-1 forms cytoplasmic granules in C. elegans germline [0.03%]
C. elegans生殖细胞中的动粒蛋白成分HCP-1形成胞质颗粒
Hannah L Hertz,Ian F Price,Wen Tang
Hannah L Hertz
The kinetochore is a multiprotein complex that assembles on centromeric chromatin and serves as the attachment site for spindle microtubules, thereby ensuring accurate chromosome segregation during cell division. Here we present evidence th...
Zeinab Rekad,Stavroula Mili,Ellen Van Obberghen-Schilling et al.
Zeinab Rekad et al.
Adhesion to the extracellular environment is fundamental for cell survival, differentiation, proliferation and migration as well as for overall tissue organization. Although RNA-binding and RNA regulatory proteins have often been observed i...
Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153 [0.03%]
细胞分裂和NUP153介导的早熟衰老相关核膜重塑
Ayse Mubine Turkmen,Jing Wang,Adam Frost et al.
Ayse Mubine Turkmen et al.
The nuclear envelope (NE) undergoes dynamic remodeling during both physiological and pathological processes. Nuclei in cells from patients with accelerated aging diseases and from elder individuals are often lobular and convoluted. Despite ...
Ritobrata Ghose,Victoria Sanz-Moreno
Ritobrata Ghose
Amoeboid behaviour represents a distinct and clinically significant cancer cell state within the epithelial-to-mesenchymal transition (EMT) spectrum. Defined by the loss of cell-cell junctions and adoption of a rounded morphology, amoeboid ...
Multiple ammonium transporters in fission yeast are coordinated by transcriptional and localization regulation in response to nitrogen starvation [0.03%]
模式酵母通过转录和定位调控协调多种铵转运蛋白响应氮饥饿反应
Yukiko Nakase,Ng Shet Lee,Amelia Tan Cheng Wei et al.
Yukiko Nakase et al.
Ammonium is a preferred nitrogen source for microorganisms. We investigated the regulation of ammonium transporters Amt1, Amt2, and Amt3 in the fission yeast Schizosaccharomyces pombe. Expression of the amt1+ gene increases under nitrogen s...
Escorting mRNAs - the multifunctional and divergent roles of cap-chaperones in post-transcriptional gene expression [0.03%]
携陪信使RNA：转录后基因表达中多功能且多样的冠伴侣的作用
Caleb M Embree,Katherine L B Borden
Caleb M Embree
Transcripts undergo a variety of processing steps - including splicing, nuclear export and translation - to ultimately produce their protein product in the required form. Deviations in these steps can produce proteins with altered or ablate...
LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death [0.03%]
LRRK2突变通过铁过载阻断NCOA4转运导致细胞发生铁死亡
Andres Goldman,Mai Nguyen,Joel Lanoix et al.
Andres Goldman et al.
Altered iron homeostasis has long been implicated in Parkinson's Disease (PD), although the mechanisms have not been clear. Given the critical role of PD-related activating mutations in LRRK2 (leucine-rich repeat protein kinase 2) within me...
Asymmetrical microtubule organizing centers drive posterior nuclei positioning in Ciona notochord development [0.03%]
Hongzhe Peng,Runyu Qiao,Jinghan Qiao et al.
Hongzhe Peng et al.
As the central organelle of cell, nucleus positioning affects diverse cell behaviors, including cell proliferation, migration, deformation, and polarity establishment, playing important roles in tissue and organ morphogenesis. However, the ...
Practical statistics for bioimage analysis - a guide to experimental design and data interpretation [0.03%]
实用的生物图像分析统计方法——实验设计和数据解释指南
Stefania Marcotti,Lina Gerontogianni,Gavin Kelly et al.
Stefania Marcotti et al.
Bioimage analysis is a powerful tool for investigating complex biological processes, but its robustness depends on technical precision and rigorous experimental design. In particular, the use of appropriate controls and experimental repetit...
Loss of cyclase-associated protein 2 alters actin cytoskeleton organization and biomechanical properties of the ocular lens [0.03%]
肌动蛋白细胞骨架组织和光学透镜的生物力学属性因cyclase相关蛋白质2丢失而发生改变
Sepideh Cheheltani,Megan Coffin,Velia M Fowler
Sepideh Cheheltani
Cyclase-associated protein 2 (CAP2) is a conserved actin-binding protein that promotes actin filament (F-actin) turnover by disassembling ADF/cofilin-decorated filaments, supporting F-actin remodeling in differentiating cells and tissues. I...