Dystrophin interacts with Msp300 to regulate myonuclear positioning and microtubule organization [0.03%]
dystrophin通过调节肌核定位和微管组织与Msp300相互作用
Jorel R Padilla,Yunshu Qiu,Gretchen Kimmel et al.
Jorel R Padilla et al.
During Drosophila myogenesis, myonuclei are actively moved during embryogenesis, and their spacing is maintained through an anchoring mechanism in the fully differentiated myofiber. While we have identified microtubule associated proteins, ...
Shalom Borst Pauwels,Jacques Neefjes,Birol Cabukusta
Shalom Borst Pauwels
The unique lipid composition of organelles defines their identity and is fundamental to their function. Lipid transfer proteins perform non-vesicular trafficking of lipids among cellular membranes to maintain their lipid compositions. Lipid...
Urinary renal epithelial cells for NPHP1 phenotyping and personalized therapeutic response [0.03%]
尿肾上皮细胞用于NPHP1表型和个性化治疗反应分析
Praveen Dhondurao Sudhindar,Eric Olinger,Zachary T Sentell et al.
Praveen Dhondurao Sudhindar et al.
Nephronophthisis (NPHP) is a recessive tubulointerstitial nephropathy and a leading genetic cause of kidney failure in children and young adults. The most common genetic cause is a homozygous deletion of NPHP1, which encodes nephrocystin-1,...
Survivin can alter mitochondrial architecture by regulating phosphatidylethanolamine synthesis [0.03%]
survivin通过调节磷脂酰乙醇胺的合成来改变线粒体结构
Lucia Dunajová,Amelia Townley,Sophie Rochette et al.
Lucia Dunajová et al.
Survivin (encoded by BIRC5) is an essential protein with established roles in mitosis and the inhibition of apoptosis. It is overexpressed in cancers, its abundance correlating with resistance to radiotherapies and chemotherapies. Survivin ...
Samantha Webster,Remi Brynn,Kate Poole
Samantha Webster
Mechanosensitive ion channels are found across all classes of life, suggesting that cellular force sensing is an ancient sense. In mammals, mechanosensitive ion channels are expressed in many cells and tissues, and disrupting their function...
Martin A Schwartz
Martin A Schwartz
Mono-ADP-ribosylating PARP enzymes in cellular signaling and disease [0.03%]
单ADP核糖基化的PARP酶在细胞信号转导和疾病中的作用
Simone Di Paola,Giovanna Grimaldi,Daniela Corda
Simone Di Paola
ADP-ribosyl-transferases (ARTs) are versatile post-translational regulators. Mammalian ARTs include poly- and mono-ADP-ribosylating enzymes, which transfer ADP-ribose molecules deriving from β-NAD+ to their targets. Mono-ADP-ribosylation (...
Quantification of Cyclin-CDK dissociation constants using FCCS with green and near-infrared fluorescent proteins [0.03%]
基于绿色和近红外荧光蛋白的FCCS技术测定细胞周期蛋白-CDK解离常数
Aika Toyama,Yuhei Goto,Yuhei Yamauchi et al.
Aika Toyama et al.
The cell cycle is a highly coordinated process governed by cyclin-bound cyclin-dependent kinases (CDKs). While the interaction between cyclin and CDK are well-documented, the dissociation constants (Kd) between specific cyclin-CDK pairs wit...
Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain epithelial barrier [0.03%]
Piezo1通过平衡膜张力和细胞质张力稳定细胞间连接并维持上皮屏障功能
Ahsan Javed,Aki Stubb,Clémentine Villeneuve et al.
Ahsan Javed et al.
Formation of the skin barrier is essential for organismal survival and tissue homeostasis. Barrier formation requires positioning of functional tight junctions (TJ) to the most suprabasal viable layer of the epidermis through a mechanical c...
Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages [0.03%]
吞噬细胞溶酶体库的枯竭导致巨噬细胞的吞咽作用力耗尽
Aaron Fountain,Mélanie Mansat,Tracy Lackraj et al.
Aaron Fountain et al.
During phagocytosis, a phagocytic cup grows via F-actin remodelling and localized secretion to entrap a particle within a phagosome, which then fuses with endosomes and lysosomes to digest the particle, followed by phagosome resolution. As ...