LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death [0.03%]
LRRK2突变通过铁过载阻断NCOA4转运导致细胞发生铁死亡
Andres Goldman,Mai Nguyen,Joel Lanoix et al.
Andres Goldman et al.
Altered iron homeostasis has long been implicated in Parkinson's Disease (PD), although the mechanisms have not been clear. Given the critical role of PD-related activating mutations in LRRK2 (leucine-rich repeat protein kinase 2) within me...
Asymmetrical microtubule organizing centers drive posterior nuclei positioning in Ciona notochord development [0.03%]
Hongzhe Peng,Runyu Qiao,Jinghan Qiao et al.
Hongzhe Peng et al.
As the central organelle of cell, nucleus positioning affects diverse cell behaviors, including cell proliferation, migration, deformation, and polarity establishment, playing important roles in tissue and organ morphogenesis. However, the ...
Practical statistics for bioimage analysis - a guide to experimental design and data interpretation [0.03%]
实用的生物图像分析统计方法——实验设计和数据解释指南
Stefania Marcotti,Lina Gerontogianni,Gavin Kelly et al.
Stefania Marcotti et al.
Bioimage analysis is a powerful tool for investigating complex biological processes, but its robustness depends on technical precision and rigorous experimental design. In particular, the use of appropriate controls and experimental repetit...
Loss of cyclase-associated protein 2 alters actin cytoskeleton organization and biomechanical properties of the ocular lens [0.03%]
肌动蛋白细胞骨架组织和光学透镜的生物力学属性因cyclase相关蛋白质2丢失而发生改变
Sepideh Cheheltani,Megan Coffin,Velia M Fowler
Sepideh Cheheltani
Cyclase-associated protein 2 (CAP2) is a conserved actin-binding protein that promotes actin filament (F-actin) turnover by disassembling ADF/cofilin-decorated filaments, supporting F-actin remodeling in differentiating cells and tissues. I...
Tetraploid Caenorhabditis elegans embryos exhibit enhanced tolerance to osmotic stress [0.03%]
四倍体秀丽隐杆线虫胚胎表现出对渗透压胁迫的耐受性增强
Yuiko Oyama,Misako Ohama,Namu Yamada et al.
Yuiko Oyama et al.
Polyploidy is a widespread phenomenon in development and evolution and is frequently associated with altered cellular physiology and developmental robustness. However, how genome doubling influences an embryonic robustness to environmental ...
Mask modulates Toll signaling by regulating the levels of Cactus in Drosophila [0.03%]
Mask通过调节果蝇中Cactus的水平来调控Toll信号通路
Bappi Sarkar,Mousumi Mutsuddi,Ashim Mukherjee
Bappi Sarkar
Innate immunity serves as the first line of defense against pathogens, requiring precise regulation to maintain immune homeostasis. The Toll signaling pathway is a central regulator of immune responses in both Drosophila and mammals, with i...
The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A [0.03%]
高尔基体囊泡衔接蛋白p115/USO1可以直接与内质网出芽位点组织者Sec16A结合
Igor Yakunin,Alison K Gillingham,Conceição Pereira et al.
Igor Yakunin et al.
Newly made secretory and membrane proteins exit the endoplasmic reticulum (ER) in COPII vesicles that form at specialised ER exit sites. These exit sites are typically near to the early Golgi compartments that receive these vesicles. A key ...
Radical diffusion, not lifetime, determines the range of Peroxidase-based proximity labelling [0.03%]
过氧化物酶介导的邻近标记的标记范围由分子扩散决定而非底物半衰期决定
Samarpita Sen,Daniel St Johnston
Samarpita Sen
Proximity-labelling offers a powerful strategy for mapping the molecular composition in the vicinity of a protein of interest. Here, we employed APEX2- and HRP-mediated biotinylation in the Drosophila follicular epithelium to analyse the ap...
Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate [0.03%]
肌动蛋白结合蛋白Profilin 1依赖性调节细胞磷脂酰肌醇(4,5)二磷酸的分子机制
Andrew Orenberg,Michael Chirumbolo,Ian Eder et al.
Andrew Orenberg et al.
Phosphatidylinositol (4,5)-bisphosphate (PIP2), the most abundant cellular poly-phosphoinositide (PPI) class of phospholipid, is a central plasma membrane (PM)-associated signaling hub that controls many cellular processes. In this study, w...
Progerin cross-linking stiffens the nucleus and impairs mechanosensation in Hutchinson-Gilford progeria syndrome [0.03%]
质核交联可使细胞核僵硬并损害霍奇金-吉尔福德进行性早老症患者的细胞机械感受功能
Luv Kishore Srivastava,Ajinkya Ghagre,Ioannidis Duchastel-Vassaramva et al.
Luv Kishore Srivastava et al.
Nuclear mechanosensation enables cells to detect and respond to mechanical cues through deformation governed by lamina and chromatin stiffness. In Hutchinson-Gilford Progeria Syndrome (HGPS), whether nuclear stiffening arises from progerin ...