Mlp1 and Mlp2 cooperate to build a stoichiometric nuclear pore basket in budding yeast [0.03%]
芽抱酵母Mlp1和Mlp2合作构建核孔的稳定结构框架
Keri Schmidt,Alexandra P Schürch,Elisa Dultz
Keri Schmidt
The nuclear pore complex is the only gateway between the nucleus and the cytoplasm in eukaryotic cells. Its nucleoplasmic face is decorated by the nuclear basket, a filamentous structure with important roles in mRNA export and chromatin org...
Coral Y Zhou
Coral Y Zhou
Across the tree of life, genome size varies by at least six orders of magnitude. Yet, all genomes perform the same essential functions required for cell survival: transcription, chromosome segregation and replication. In this Review, we app...
A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment [0.03%]
一种保守的Arf-GEF通过改变神经-表皮连接调控RAB-35来维持轴突的完整性
Igor Bonacossa-Pereira,Dat Le,Sean Coakley et al.
Igor Bonacossa-Pereira et al.
Neurites of sensory neurons innervate the skin and are embedded within it. These delicate structures are chronically exposed to mechanical strain and yet their integrity is maintained throughout life. In C. elegans, UNC-70/β-spectrin funct...
Transcription clusters and developmental pathways - nature, nurture, noise [0.03%]
转录簇与发育途径-天性、环境和随机性
Peter R Cook
Peter R Cook
Establishing how the genomic DNA sequence determines cell fate is a grand challenge in biology. It is usually approached from the viewpoint that each gene is transcribed independently of others. However, there is increasing evidence that cl...
Decoding intrinsically disordered regions in chromatin dysfunction and cancer [0.03%]
染色质功能障碍和癌症中内在无序区域的解读
Audrey W Hong,Colleen E Hannon,Amy R Strom
Audrey W Hong
Intrinsically disordered regions (IDRs) are pervasive in chromatin regulatory proteins, where their dynamic, multivalent interactions organize nuclear biochemistry, in some cases through biomolecular condensation. Because ∼20% of cancer-dr...
Hac1-independent functions of Ire1 drive morphogenesis in Candida albicans through distinct transcriptional programs [0.03%]
通过不同的转录程序，Ire1的Hac1非依赖性功能通过独立的转录程序驱动白念珠菌的形态发生
Samuel Stack-Couture,Gabriela Nunes Marsiglio Librais,Bryan Lung et al.
Samuel Stack-Couture et al.
The pathogenic yeast Candida albicans relies on morphogenesis-the transition from spherical yeast to filamentous hyphal forms-for infection. While morphogenesis requires Ire1, a transmembrane protein that canonically initiates the Unfolded ...
N-cadherin mediates replicative senescence of mesenchymal stem cells via regulation of intercellular adhesion [0.03%]
N-钙黏着蛋白通过调节细胞间粘附介导间充质干细胞的复制衰老
Xiangyu Dong,Qian Sun,Mengchen Tu et al.
Xiangyu Dong et al.
Human mesenchymal stem cells (hMSCs) undergo progressive functional decline during long-term ex vivo expansion, which limits their therapeutic potential. However, the contribution of intercellular adhesion to this process remains unclear. B...
Live imaging of epithelial phagocyte differentiation in the Drosophila ovary reveals transient and novel behaviors [0.03%]
果蝇卵巢上皮吞噬细胞分化活体成像揭示了短暂且新颖的行为特征
Caique Almeida Machado Costa,Cristian Santiago Santiago,Jie Sun et al.
Caique Almeida Machado Costa et al.
The transformation of epithelial cells into non-professional phagocytes (NPPs) is a conserved and versatile adaptation that occurs in response to immune challenges, tissue remodeling and apoptotic debris clearance. In the Drosophila melanog...
The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter [0.03%]
围绕秀丽隐杆线虫中心体的细胞膜网络可能是一种微管过滤器
Richa Maheshwari,Mohammad M Rahman,Abigail Ruddick et al.
Richa Maheshwari et al.
Centrosomes are cytoplasmic microtubule-nucleating structures. They are considered membraneless organelles, but in several cell types they are surrounded by ER-derived membrane. In C. elegans early embryos, this membrane forms a dense membr...
Regulation of Leishmania surface coat proteins by the nuclear protein ESB1 [0.03%]
ESB1调控莱什曼原虫表层蛋白涂层的机制研究
Jorge Adrián Arias Del Angel,Ulrich Dobramysl,Laura Davidson et al.
Jorge Adrián Arias Del Angel et al.
Unicellular Leishmania parasites cause leishmaniases and require a life cycle stage-specific surface coat for pathogenesis. A major protein component of this coat is δ-amastins, which are human infective amastigote life cycle stage-specifi...