Insights into the translational activation mechanisms of the COX1 mRNA in yeast mitochondria [0.03%]
酵母线粒体中COX1 mRNA翻译起始机制的初步研究
Angelica Zamudio-Ochoa,Yolanda Camacho-Villasana,Ulrik Pedroza-Dávila et al.
Angelica Zamudio-Ochoa et al.
Mitochondrial translation is a crucial regulatory step in mitochondrial genome expression. In Saccharomyces cerevisiae, translational activators are believed to bind to the 5' UTRs of their target mRNAs to position the mitochondrial ribosom...
Acentrosomal aster with atypical microtubule polarity recruits cytokinesis signals to its center in Xenopus egg extracts [0.03%]
缺乏中心体的星状体通过募集非典型微管极性在非洲爪蟾卵母细胞中招募细胞分裂信号至其中心区域
Ling Jin,Muchen Liu,Xianrui Cheng
Ling Jin
Xenopus egg extracts can self-organize into cell-like compartments without the classic microtubule organizer centrosome. Compartment formation requires microtubules, but the organization of microtubules throughout the process remains unclea...
Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages [0.03%]
组蛋白脱乙酰酶7介导脂多糖诱导的巨噬细胞线粒体分裂
Rishika Abrol,Syeda Farhana Afroz,James E B Curson et al.
Rishika Abrol et al.
Histone deacetylase 7 (HDAC7) drives several immunometabolism-related processes in macrophages including lipopolysaccharide (LPS)-inducible glycolysis and inflammatory mediator production. Using an advanced biotin ligase TurboID system in h...
Object Stitching by Clustering of adjacent Regions designed for accurate quantification of three-dimensional tissues [0.03%]
一种用于精确量化三维组织的邻近区域聚类图像对象缝合方法
Mario Ledesma-Terrón,Diego Pérez-Dones,Diego Mazo-Durán et al.
Mario Ledesma-Terrón et al.
The study of tissue organization and morphogenesis requires quantitative analysis of three-dimensional biological samples, a challenging task due to limitations in imaging dense organs at single-cell resolution. Current 3D segmentation and ...
Stepan Vodopyanov,Leslie Gunther-Cummins,Sophia DesMarais et al.
Stepan Vodopyanov et al.
The thymus originates from the third pharyngeal pouch endoderm, which also gives rise to respiratory tract elements. Here, we examined intrathymic cystic structures, long considered remnants of organogenesis. Through sequential histology an...
Endocytic patch dynamics are differentially regulated at distinct cell sites in fission yeast [0.03%]
裂殖酵母不同细胞位点的内吞补丁动力学差异调节
Bethany F Campbell,Dhanya Kalathil,Uma J Patel et al.
Bethany F Campbell et al.
Endocytosis promotes polarity and growth in eukaryotes. In Schizosaccharomyces pombe fission yeast, endocytosis occurs at the polarized cell ends and division site and at the non-polarized cell sides. Our characterization of endocytic actin...
Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2 [0.03%]
牛磺酸胚胎上皮细胞的跨细胞收缩性由细胞外ATP和嘌呤受体P2Y2调节
Sagar D Joshi,Timothy R Jackson,Lin Zhang et al.
Sagar D Joshi et al.
Extracellular signals regulate epithelial homeostasis, cell fate and pattern cell behaviors during embryogenesis, wound healing, regeneration, and disease progression. Previous studies in our group found cell lysate from intentionally wound...
Impaired biogenesis of renin granules in the juxtaglomerular cells of Vps33a (D251E) murine mutant [0.03%]
Vps33a(D251E)突变小鼠近曲肾单位细胞肾素颗粒生物生成受损
Huipeng Wang,Zhenhua Hao,Wei Li
Huipeng Wang
Renin is mainly stored in the renin granules (RGs) of juxtaglomerular cells (JGCs). Being a type of lysosome-related organelles (LROs), the underlying mechanism of RG biogenesis is very limited. Hermansky-Pudlak syndrome (HPS) is characteri...
WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm [0.03%]
TCF/LEF转录因子在人类多能性和细胞谱系中的表达与啮齿动物有所不同，且不以Wnt信号通路依赖的方式介导
Connor Ross,Paula A Balestrini,Lawrence E Bates et al.
Connor Ross et al.
Embryonic stem cell research has uncovered different requirements for WNT/β-catenin signalling in human naïve pluripotent cells compared to the mouse paradigm. It is therefore important to study WNT/β-catenin signalling directly in model...
Tatsat Banerjee,Yu Deng,Dhiman Sankar Pal et al.
Tatsat Banerjee et al.
Waves of signaling and cytoskeletal components, which can be easily seen propagating on the ventral surface of a cell, are a systemic feature of biochemical networks that define the spatiotemporal dynamics of diverse cell physiological proc...