Pascal Höhne,Marie Hugenroth,Maria Bohnert
Pascal Höhne
The nucleus-vacuole junction (NVJ) is a central membrane contact site in yeast that connects the nuclear endoplasmic reticulum and the vacuole. This organelle interface is heavily involved in the handling of lipids: it houses numerous lipid...
Loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoids [0.03%]
INPP5E的丢失影响了由人多能干细胞衍生视网膜类器官中的感光细胞外节膜的生成
Kae R Whiting,Mariam G Aslanyan,Lynn van Summeren et al.
Kae R Whiting et al.
Mutations in the ciliary gene INPP5E, encoding inositol polyphosphate-5-phosphatase E (INPP5E), can cause retinal degeneration as part of the ciliopathy Joubert Syndrome or non-syndromic retinitis pigmentosa (RP). INPP5E regulates the membr...
Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells [0.03%]
Brinker调控干细胞与分化细胞之间BMP信号的相互作用结果
Samaneh Poursaeid,Jeffrey P Gamer,Mayu Inaba
Samaneh Poursaeid
Drosophila male germline stem cells (GSCs) reside at the testis tip, surrounding a cluster of niche cells known as the hub. Bone Morphogenetic Protein (BMP) ligands secreted from the hub exert both contact-dependent and -independent effects...
Primary cilium disassembly - from mechanisms to roles in physiology and disease [0.03%]
原纤毛解聚-从机制到生理和疾病中的作用
Carolyn M Ott,Jennifer Lippincott-Schwartz,David K Breslow
Carolyn M Ott
Primary cilia are micron-scale cellular compartments with key roles in cell signaling and disease. Cilium assembly has been delineated as a multi-step process that is disrupted in ciliopathies, yet many features of cilia disassembly remain ...
Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae [0.03%]
隐性端粒附近基因表达需要凝缩素的泛素化修饰
Deepash Kothiwal,Shalu Joseph,Shikha Laloraya
Deepash Kothiwal
Cohesin, first described for its role in sister chromatid cohesion, impacts several chromosomal processes, some of which (chromosome segregation, replication and repair) are regulated by its post-translational modifications. Previously, we ...
Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest [0.03%]
库姆洛斯细胞通过促进DNA损伤诱导的减数分裂停滞来增强卵母细胞的基因组质量控制能力
Chenxi Zhou,Brett McKinnon,Hayden Homer
Chenxi Zhou
Cumulus cells are known to maintain oocyte arrest at prophase I through gap junction-mediated cAMP signalling, but their role after meiotic resumption remains unclear. Here, we show that cumulus cells enhance oocyte genomic quality control ...
Mlp1 and Mlp2 cooperate to build a stoichiometric nuclear pore basket in budding yeast [0.03%]
芽抱酵母Mlp1和Mlp2合作构建核孔的稳定结构框架
Keri Schmidt,Alexandra P Schürch,Elisa Dultz
Keri Schmidt
The nuclear pore complex is the only gateway between the nucleus and the cytoplasm in eukaryotic cells. Its nucleoplasmic face is decorated by the nuclear basket, a filamentous structure with important roles in mRNA export and chromatin org...
Coral Y Zhou
Coral Y Zhou
Across the tree of life, genome size varies by at least six orders of magnitude. Yet, all genomes perform the same essential functions required for cell survival: transcription, chromosome segregation and replication. In this Review, we app...
A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment [0.03%]
一种保守的Arf-GEF通过改变神经-表皮连接调控RAB-35来维持轴突的完整性
Igor Bonacossa-Pereira,Dat Le,Sean Coakley et al.
Igor Bonacossa-Pereira et al.
Neurites of sensory neurons innervate the skin and are embedded within it. These delicate structures are chronically exposed to mechanical strain and yet their integrity is maintained throughout life. In C. elegans, UNC-70/β-spectrin funct...
Transcription clusters and developmental pathways - nature, nurture, noise [0.03%]
转录簇与发育途径-天性、环境和随机性
Peter R Cook
Peter R Cook
Establishing how the genomic DNA sequence determines cell fate is a grand challenge in biology. It is usually approached from the viewpoint that each gene is transcribed independently of others. However, there is increasing evidence that cl...