A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65 [0.03%]
涉及TMED9和GRASP65的前proTGFα高尔基体旁路分泌机制
Susanne S Steigleder,Isabel Döring,Marina Tauber et al.
Susanne S Steigleder et al.
We recently demonstrated that the endoplasmic reticulum export of proTGFα is tightly gated and that proteostasis factors, including the intramembrane protease RHBDL4, can promote its release by an unknown mechanism. While investigating a p...
A Tca17TRAPPC2L/TRAPPC11/12/13 subcomplex directs TRAPPIII to autophagy [0.03%]
Tca17TRAPPC2L/TRAPPC11/12/13亚复合物可将TRAPPIII导向自噬
Mario Pinar,Vivian de Los Ríos,Silvia Rodríguez-Pires et al.
Mario Pinar et al.
TRAPP complexes are master regulators of membrane trafficking. TRAPPs are targeted to different locales by pathway-specific subunits decorating a core hetero-heptamer to build TRAPPII (Golgi exit) and TRAPPIII (autophagosomes and ER-Golgi t...
Lizanne Oliveira,Jomon Joseph
Lizanne Oliveira
Annulate lamellae (AL) are endoplasmic reticulum (ER) subdomains harbouring a subset of nucleoporins (Nups), the proteins that assemble into the nuclear pore complexes (NPCs) on the nuclear envelope (NE). AL have been observed in a variety ...
SNED1 fibrillar assembly in the extracellular matrix requires fibronectin and collagen I [0.03%]
纤连蛋白和胶原I对细胞外基质中SNEDD1纤维聚集体形成是必需的
Leanna Leverton,Dharma Pally,Asantewaa Jones et al.
Leanna Leverton et al.
The extracellular matrix (ECM) is a meshwork of proteins that orchestrates a broad range of cellular phenotypes, including proliferation, adhesion, migration, and differentiation. SNED1 is a newly characterized ECM glycoprotein that promote...
The yeast DENN domain protein Avl9 contributes to recycling and sorting of endosomal cargos [0.03%]
酵母DENN结构域蛋白Avl9参与内体货物的循环和分拣
Daniel J Rioux,Samreen Manj,Derek C Prosser
Daniel J Rioux
In yeast and humans, the conserved DENN-domain (Differentially Expressed in Normal and Neoplastic tissue) protein Avl9 is thought to play roles in membrane traffic and secretion, but its precise function remains poorly defined. Since DENN-c...
OpticalFlow3D - a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images [0.03%]
光学流3D——一种测量三维荧光显微图像中无定形运动的工具
Rachel M Lee,Leanna R Eisenman,Chad M Hobson et al.
Rachel M Lee et al.
Motion is an essential component of any living system. It is rich with information, but it is often challenging to quantitatively extract biologically informative results from the motion apparent in microscopy images. This challenge is exac...
Metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis by dopamine [0.03%]
多巴胺诱导代谢型谷氨酸受体内吞和突触AMPA受体内化
K Aruna,Mitra Kulkarni,Samarjit Bhattacharyya
K Aruna
Group I metabotropic glutamate receptors (mGluRs) play important roles in synaptic function, plasticity and in many neuropsychiatric disorders. Trafficking plays crucial roles in proper targeting of these receptors in specific region of the...
Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans [0.03%]
染色体激酶Klp-19调节秀丽隐杆线虫中期有丝分裂微管重叠和动力学
Vitaly Zimyanin,Magdalena Magaj,Nadia Ingabire Manzi et al.
Vitaly Zimyanin et al.
Recent studies have highlighted the significance of the spindle midzone in ensuring proper chromosome segregation. Using 3D electron tomography, light microscopy, and a single-cell in vitro assay for single-molecule tracking, we investigate...
Anoxia tolerant DNA replication is supported by ATR kinase in the annual killifish Austrofundulus limnaeus [0.03%]
年杀鱼Austrofundulus limnaeus中ATR激酶支持缺氧耐受性DNA复制
Riley Roth-Carter,Erin Helms,Joshua C Saldivar et al.
Riley Roth-Carter et al.
Hypoxia and anoxia suppress cell proliferation due to an increase in replication stress and activation of DNA damage checkpoints. Embryos of the annual killifish Austrofundulus limnaeus tolerate prolonged anoxia, indicating improved genomic...
SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif [0.03%]
SNED1通过其LDV整合素结合基序调节细胞外基质架构和细胞增殖
Dharma Pally,Leanna Leverton,Asantewaa Jones et al.
Dharma Pally et al.
The extracellular matrix (ECM) is a complex scaffold of proteins that supports multicellular structures. Interactions between cells and the ECM via receptors, like integrins, govern cellular phenotypes (e.g., proliferation, adhesion), but a...