Phosphorylation of VAMP3 couples IL-6 Exocytosis to dendritic cell activation [0.03%]
VAMP3的磷酸化将IL-6的胞外分泌偶联到树突状细胞活化过程中
Tongxiang Chen,Anthi Psoma,Shweta Mahajan et al.
Tongxiang Chen et al.
Adaptive immunity is critical for combating pathogens and generating immunological memory. Central to adaptive immunity are myeloid cells, which activate upon pathogen detection. Activation is essential for inflammatory cytokine release and...
Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division [0.03%]
小鼠CDK2的不同剪接异构体在有丝分裂和减数分裂中起功能冗余作用
Nathan Palmer,Nisan Ece Kalem-Yapar,Hanna Hultén et al.
Nathan Palmer et al.
In most mammals, the cell cycle kinase; cyclin-dependent kinase 2 (CDK2) is expressed as two major isoforms due to alternative splicing. The shorter CDK2 isoform: CDK2S, is expressed constitutively during the cell cycle and can be detected ...
The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing [0.03%]
小鼠嗅球浅层托状细胞和迷走细胞输出神经元在胰岛素感知中具有双重作用
Louis John Kolling,Saptarsi Mitra,Catherine Anne Marcinkiewcz et al.
Louis John Kolling et al.
The olfactory bulb (OB) contains multiple, parallel projection neurons to relay the nature of a stimulus. In a mouse ex vivo slice preparation, we used patch-clamp electrophysiology to measure intrinsic properties, excitability, action pote...
RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway [0.03%]
RhoGEF2过表达通过Ptp10D、Crumbs和Hippo信号通路诱导细胞竞争
Natasha Fahey-Lozano,Marta Portela,John E La Marca et al.
Natasha Fahey-Lozano et al.
In Drosophila melanogaster larval epithelial tissues, cells containing mutations in the apico-basal polarity protein, Scrib, are eliminated by cell competition when surrounded by wild-type cells. In scrib mutant cells, signaling mediated by...
Allele-specific conformational rescue of KIF1A(T99M) by genetic suppressors in a C. elegans model of KIF1A-associated neurological disorder [0.03%]
利用遗传抑制因子缓解KIF1A（T99M）突变体在秀丽隐杆线虫模型中KIF1A相关神经病变中的构象异常现象
Zihan Chen,Yongping Chai,Zhengyang Guo et al.
Zihan Chen et al.
KIF1A-associated neurological disorder (KAND) arises from mutations in the microtubule motor KIF1A, disrupting synaptic vesicle transport. Here, we investigate the pathogenic T99M substitution in KIF1A's P-loop, which induces steric hindran...
Regulation of cell shape and mechanics by Rho GEF/GAP in a proliferative epithelial tissue [0.03%]
Rho GEF/GAP调节增殖上皮组织的细胞形状和力学性质
Emeline Durel,Nathalie Bécot,Mathieu Pinot et al.
Emeline Durel et al.
Epithelial cell shape results from the combination of intrinsic properties of the actomyosin cytoskeleton and extrinsic properties due to physical interactions with neighbouring cells, in particular at the adherens junctions. In the Drosoph...
Lipid Nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models [0.03%]
脂质纳米颗粒包裹的Dnai1 mRNA可修复囊性纤维化小鼠细胞模型中的纤毛活性
Amanda J Smith,Patrick R Sears,Mirko Hennig et al.
Amanda J Smith et al.
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogenous disorder resulting from dysfunctional motile cilia that is characterized by chronic, progressive lung disease with currently no corrective therapies available. Here, we te...
MLL/WDR5 complex promotes recruitment of KIF2C to midbody to ensure MT depolymerization and furrow initiation during cytokinesis [0.03%]
MLL/WDR5复合体促进KIF2C募集到细胞中体以确保有丝分裂胞质分裂期间微管解聚和裂沟启动
Avishek Kataria,Neeraja Hemalatha,Akash Chinchole et al.
Avishek Kataria et al.
Mixed-lineage leukemia (MLL) protein is a well-characterised epigenetic regulator whose non-canonical activities remain underappreciated. MLL has been shown to localize on the midbody and loss of this protein leads to binucleation. However,...
Morphological reprogramming of primary cilia length mitigates the fibrotic phenotype in fibroblasts across diverse fibrotic conditions [0.03%]
原发纤毛长度的形态重塑可缓解纤维化条件下成纤维细胞的纤维化表型
Priyanka Verma,Bharat Yalavarthi,Swati Bhattacharyya et al.
Priyanka Verma et al.
Myofibroblast differentiation, shared across fibrotic diseases, is marked by actin polymerization and assembly of αsmooth muscle actin (αSMA) stress fibers. Primary cilia (PC) are solitary membrane-bound organelles present on the majority...
Glutamate decreases oxidative stress and lipid droplet formation in astrocytes [0.03%]
谷氨酸减少星形胶质细胞中的氧化应激和脂滴形成
Luis Fernando Rubio-Atonal,Jinlan Chang,Julie Jacquemyn et al.
Luis Fernando Rubio-Atonal et al.
Astrocytes degrade fatty acids in response to glutamate while reducing the abundance of lipid droplets. But how glutamate regulates lipid droplets in astrocytes is unclear. Here we show that glutamate decreases the amount of reactive oxygen...