Metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis by dopamine [0.03%]
多巴胺诱导代谢型谷氨酸受体内吞和突触AMPA受体内化
K Aruna,Mitra Kulkarni,Samarjit Bhattacharyya
K Aruna
Group I metabotropic glutamate receptors (mGluRs) play important roles in synaptic function, plasticity and in many neuropsychiatric disorders. Trafficking plays crucial roles in proper targeting of these receptors in specific region of the...
Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans [0.03%]
染色体激酶Klp-19调节秀丽隐杆线虫中期有丝分裂微管重叠和动力学
Vitaly Zimyanin,Magdalena Magaj,Nadia Ingabire Manzi et al.
Vitaly Zimyanin et al.
Recent studies have highlighted the significance of the spindle midzone in ensuring proper chromosome segregation. Using 3D electron tomography, light microscopy, and a single-cell in vitro assay for single-molecule tracking, we investigate...
Anoxia tolerant DNA replication is supported by ATR kinase in the annual killifish Austrofundulus limnaeus [0.03%]
年杀鱼Austrofundulus limnaeus中ATR激酶支持缺氧耐受性DNA复制
Riley Roth-Carter,Erin Helms,Joshua C Saldivar et al.
Riley Roth-Carter et al.
Hypoxia and anoxia suppress cell proliferation due to an increase in replication stress and activation of DNA damage checkpoints. Embryos of the annual killifish Austrofundulus limnaeus tolerate prolonged anoxia, indicating improved genomic...
SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif [0.03%]
SNED1通过其LDV整合素结合基序调节细胞外基质架构和细胞增殖
Dharma Pally,Leanna Leverton,Asantewaa Jones et al.
Dharma Pally et al.
The extracellular matrix (ECM) is a complex scaffold of proteins that supports multicellular structures. Interactions between cells and the ECM via receptors, like integrins, govern cellular phenotypes (e.g., proliferation, adhesion), but a...
Endothelial cell biomechanical adaptation to altered connexin 43 expression under fluid shear stress [0.03%]
流体切应力下缝隙连接蛋白43表达改变对内皮细胞生物力学适应的影响
Md Mydul Islam,Vignesharavind Subramanianbalachandar,Robert Steward
Md Mydul Islam
We examined how pharmacological modulation of connexin 43 (Cx43) regulates endothelial biomechanics under static conditions and laminar fluid shear stress (FSS). Cx43 activity was either inhibited with 2',5'-dihydroxychalcone (chalcone) or ...
rRNA transcription is regulated by sequestering LATS2 and PHF6 to the nuclear speckle following DNA damage [0.03%]
DNA损伤后LATs2和PHF6被募集到核内点状结构调控rRNA转录
Hirokazu Suzuki,Satomi Mukai,Yorika Kato et al.
Hirokazu Suzuki et al.
Mammalian large tumor suppressor 2 (LATS2) is an evolutionarily conserved Ser/Thr kinase that regulates the Hippo signaling pathway and cell cycle checkpoints. In this study, we demonstrate that ultraviolet (UV) irradiation causes the phosp...
Establishing MS2-MCP-based single-molecule RNA visualization in Schizosaccharomyces pombe [0.03%]
在模式生物粟酒裂殖酵母中建立MS2-MCP单分子RNA原位可视化技术
Douglas E Weidemann,Sarah C Turner,Samir G Chethan et al.
Douglas E Weidemann et al.
Single-molecule RNA imaging using the MS2-MCP system has transformed the study of RNA biology across model organisms. However, this technology has remained unavailable for fission yeast (Schizosaccharomyces pombe) even though fission yeast ...
LGI1-ADAM22 complex organizes PSD93 clustering at the axon initial segment [0.03%]
LGI1-ADAM22复合物可组织PSD93在轴突初始段的聚集
Wenying Zhang,Shuyi Tan,Xiaoyu Teng et al.
Wenying Zhang et al.
Postsynaptic density-93 (PSD93) is a membrane-associated guanylate kinase (MAGUK) family scaffolding protein containing multiple PDZ domains. It assembles ion channels, receptors, and signaling molecules at synaptic and axonal membranes, pa...
Potential role of myeloid bodies in protection against photo-oxidative damage of the retinal pigment epithelium [0.03%]
关于髓样体在视网膜色素上皮光氧化损伤保护中的潜在作用
Iñigo Novales Flamarique
Iñigo Novales Flamarique
Myeloid bodies are organized forms of the smooth endoplasmic reticulum that occur in the retinal pigment epithelium of vertebrates. The latter is a monolayer of cells, situated between the neural retina and the chroroid vasculature, that is...
From the FAZ to the TAC: Widespread cytoskeletal engagement of T. brucei KMP11 [0.03%]
从FAZ到TAC：KMP11在布氏锥虫细胞骨架的广泛参与
Salome Aeschlimann,Clirim Jetishi,Caroline E Dewar et al.
Salome Aeschlimann et al.
KMP11 is a conserved kinetoplastid protein yet its precise localization and function remained unclear. Using immunofluorescence, ultrastructure expansion microscopy (U-ExM), and proteomics, we comprehensively analyzed KMP11 in procyclic Try...