Extravasation of immune and tumor cells from an endothelial perspective [0.03%]
从内皮细胞角度观察免疫和肿瘤细胞的渗出现象
Amandine Dupas,Jacky G Goetz,Naël Osmani
Amandine Dupas
Crossing the vascular endothelium is a necessary stage for circulating cells aiming to reach distant organs. Leukocyte passage through the endothelium, known as transmigration, is a multistep process during which immune cells adhere to the ...
Shear stress-stimulated AMPK couples endothelial cell mechanics, metabolism and vasodilation [0.03%]
剪切应力刺激的AMPK将内皮细胞力学、代谢和血管舒张相耦合
Nicholas M Cronin,Logan W Dawson,Kris A DeMali
Nicholas M Cronin
Endothelial cells respond to mechanical force by stimulating cellular signaling, but how these pathways are linked to elevations in cell metabolism and whether metabolism supports the mechanical response remains poorly understood. Here, we ...
Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase [0.03%]
信号肽肽酶对羊毛甾醇脱甲基酶CYP51A1的拓扑学监视
Nikita Sergejevs,Dönem Avci,Michael L van de Weijer et al.
Nikita Sergejevs et al.
Cleavage of transmembrane segments on target proteins by the aspartyl intramembrane protease signal peptide peptidase (SPP, encoded by HM13) has been linked to immunity, viral infection and protein quality control. How SPP recognizes its va...
Bi-directional regulation between inflammation and stem cells in the respiratory tract [0.03%]
呼吸道炎症与干细胞之间的双向调节关系
Jinwook Choi,Jakub Chudziak,Joo-Hyeon Lee
Jinwook Choi
Inflammation plays a crucial role in tissue injury, repair and disease, orchestrating a complex interplay of immune responses and cellular processes. Recent studies have uncovered the intricate connection between inflammation and stem cell ...
David Cohen,Dawn Fernandez,Francisco Lázaro-Diéguez et al.
David Cohen et al.
The Borg (or Cdc42EP) family consists of septin-binding proteins that are known to promote septin-dependent stress fibers and acto-myosin contractility. We show here that epithelial Borg5 (also known as Cdc42EP1) instead limits contractilit...
Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss [0.03%]
降低的DNA密度比染色质蛋白B型 lamina B丢失更能很好地体现出核胞浆伪足的现象
Samantha Bunner,Kelsey Prince,Emily M Pujadas Liwag et al.
Samantha Bunner et al.
Nuclear blebs are herniations of the nucleus that occur in diseased nuclei that cause nuclear rupture leading to cellular dysfunction. Chromatin and lamins are two of the major structural components of the nucleus that maintain its shape an...
Cell-cell junctions in focus - imaging junctional architectures and dynamics at high resolution [0.03%]
聚焦于细胞间连接——以高分辨率成像连接结构及动态变化
Vera Janssen,Stephan Huveneers
Vera Janssen
Studies utilizing electron microscopy and live fluorescence microscopy have significantly enhanced our understanding of the molecular mechanisms that regulate junctional dynamics during homeostasis, development and disease. To fully grasp t...
CAMSAP3 forms dimers via its α-helix domain that directly stabilize non-centrosomal microtubule minus ends [0.03%]
CAMSAP3通过其α-螺旋结构域形成二聚体并直接稳定非中心体微管负端
Yuejia Li,Rui Zhang,Jinqi Ren et al.
Yuejia Li et al.
Microtubules are vital components of the cytoskeleton. Their plus ends are dynamic and respond to changes in cell morphology, whereas the minus ends are stable and serve a crucial role in microtubule seeding and maintaining spatial organiza...
An image-based RNAi screen identifies the EGFR signaling pathway as a regulator of Imp RNP granules [0.03%]
基于图像的RNA干扰筛选鉴定EGFR信号通路为Imp核糖核蛋白颗粒调节通路
Fabienne De Graeve,Eric Debreuve,Kavya Vinayan Pushpalatha et al.
Fabienne De Graeve et al.
Biomolecular condensates have recently retained much attention given that they provide a fundamental mechanism of cellular organization. Among those, cytoplasmic ribonucleoprotein (RNP) granules selectively and reversibly concentrate RNA mo...
Lucy Collinson,Guillaume Jacquemet
Lucy Collinson