Regulation of miR-206 in denervated and dystrophic muscles, and its effect on acetylcholine receptor clustering [0.03%]
神经损伤和肌肉营养不良小鼠模型中miR-206的调控及其对乙酰胆碱受体聚集的影响研究
Joseph Barden,Olivia Kosloski,Amir Jadidian et al.
Joseph Barden et al.
The muscle-specific microRNA miR-206 has recently emerged as a potential regulator of genes involved in the formation and regeneration of the neuromuscular junction (NMJ). This study investigated miR-206-3p (miR-206) expression in synaptic ...
AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1 [0.03%]
AMPK通过磷酸化鸟嘌呤核苷酸交换因子GBF1与高尔基体相关并引起高尔基体片段化
Jordana B Freemantle,Mhairi C Towler,Emma R Hudson et al.
Jordana B Freemantle et al.
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular functions in response to changes in energy availability. However, whether AMPK activity is spatially regulated, and the implications for cell function, have bee...
Biphasic DNA damage and non-canonical replication stress response govern radiation-induced senescence in glioblastoma [0.03%]
辐射诱导的胶质母细胞瘤衰老受双相DNA损伤和非经典复制应激反应调控
Atanu Ghorai,Bhawna Singh,Shilpee Dutt
Atanu Ghorai
Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, but the mechanism of TIS manifestation remains obscure. Here, we demonstrate that replication stress (RS) is ...
ImmunoCellCycle-ID - a high-precision immunofluorescence-based method for cell cycle identification [0.03%]
免疫细胞周期鉴定_immunocellcycle-id：一种高精度的基于免疫荧光的细胞周期识别方法
Yu-Lin Chen,Yu-Chia Chen,Aussie Suzuki
Yu-Lin Chen
The cell cycle is a fundamental process essential for cell proliferation, differentiation and development. It consists of four major phases: G1, S, G2 and M. These phases collectively drive the reproductive cycle and are meticulously regula...
Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics and clarity [0.03%]
Ankirin-B对于晶状体细胞架构、力学和清晰性的建立与维持是必需的
Rupalatha Maddala,Ariana Allen,Nikolai P Skiba et al.
Rupalatha Maddala et al.
The transparent ocular lens is essential for vision because it focuses light onto the retina. Despite recognition of the importance of its unique cellular architecture and mechanical properties, the molecular mechanisms governing these attr...
Mutations in the DNA processivity factor POL30 predisposes the FLO11 locus to epigenetic instability in S. cerevisiae [0.03%]
DNA解旋酶PCOL30突变使模式酵母菌株中的表观遗传调控不稳定性增强
Safia Mahabub Sauty,Ashley Fisher,Andrew Dolson et al.
Safia Mahabub Sauty et al.
The FLO genes in Saccharomyces cerevisiae are repressed by heterochromatin formation, involving histone deacetylases, transcription factors and non-coding RNAs. Here, we report that mutations in the processivity factor POL30 (PCNA) that sho...
Apical integrins as a switchable target to regulate the epithelial barrier [0.03%]
顶面整合素作为可调节上皮屏障的可控靶点
Raven J Peterson,Ryan C Reed,Colin R Zamecnik et al.
Raven J Peterson et al.
Tight junctions regulate epithelial barrier function and have been shown to be influenced by multiple classes of proteins. Apical integrins have been identified as potential regulators of epithelial barrier function; however, only indirect ...
The small ARF-like 2 GTPase TITAN5 is linked with the dynamic regulation of IRON-REGULATED TRANSPORTER 1 [0.03%]
微小ARF-like 2 GTP酶TITAN5与铁调节转运蛋白1的动态调控相关联
Inga Mohr,Monique Eutebach,Marie C Knopf et al.
Inga Mohr et al.
Iron acquisition is crucial for plants. The abundance of IRON-REGULATED TRANSPORTER 1 (IRT1) is controlled through endomembrane trafficking, a process that requires small ARF-like GTPases. Only few components that are involved in the vesicu...
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types [0.03%]
《“迭代漂白扩展多重染色法”可同时鉴定所有主要视网膜细胞类型》
Aanandita A Kothurkar,Gregory S Patient,Nicole C L Noel et al.
Aanandita A Kothurkar et al.
To understand the multicellular composition of tissues, and how it is altered during development, ageing and/or disease, we must visualise the complete cellular landscape. Currently, this is hindered by our limited ability to combine multip...
Proximity labeling reveals interactions necessary to maintain the distinct apical domains of Drosophila photoreceptors [0.03%]
邻近标记揭示了维持果蝇视网膜神经元顶域特异性的相互作用
Lalitha Sastry,Johnathan Rylee,Simpla Mahato et al.
Lalitha Sastry et al.
Specialized membrane and cortical protein regions are common features of cells and are utilized to isolate differential cellular functions. In Drosophila photoreceptors, the apical membrane domain is defined by two distinct morphological me...