Nuclear blebs are associated with destabilized chromatin packing domains [0.03%]
核小体与去稳定的染色质包装结构域相关联
Emily M Pujadas Liwag,Nicolas Acosta,Luay Matthew Almassalha et al.
Emily M Pujadas Liwag et al.
Disrupted nuclear shape is associated with multiple pathological processes including premature aging disorders, cancer-relevant chromosomal rearrangements, and DNA damage. Nuclear blebs (i.e., herniations of the nuclear envelope) have been ...
Clearing the path for whole-mount labeling and quantification of neuron- and vessel-density in adipose tissue [0.03%]
脂肪组织中清除路径以进行完整倍置和神经细胞及血管密度量化的方法
Thomas Rauchenwald,Pia Benedikt-Kühnast,Sandra Eder et al.
Thomas Rauchenwald et al.
White adipose tissue (WAT) comprises a plethora of cell types beyond adipocytes forming a regulatory network that ensures systemic energy homeostasis. Intertissue communication is facilitated by metabolites and signaling molecules that are ...
Mohona Gupta,Tylor R Lewis,Michael W Stuck et al.
Mohona Gupta et al.
In humans, inositol polyphosphate-5-phosphatase e (INPP5E) mutations cause retinal degeneration as part of Joubert and MORM syndromes and can also cause non-syndromic blindness. In mice, mutations cause a spectrum of brain, kidney, and othe...
Michael Way
Michael Way
Yuka Takeo,Mac Crite,Kashif Mehmood et al.
Yuka Takeo et al.
Retromer mediates retrograde transport of protein cargos from endosomes to the trans-Golgi network (TGN). γ-secretase is a protease that cleaves the transmembrane domain of its target proteins. Although retromer can form a stable complex w...
SuperResNET: Single molecule network analysis detects changes to clathrin structure by small molecule inhibitors [0.03%]
超分辨率网络分析：通过小分子抑制剂检测clathrin结构的变化
Timothy H Wong,Ismail M Khater,Christian Hallgrimson et al.
Timothy H Wong et al.
Here, we apply SuperResNET network analysis of dSTORM single-molecule localization microscopy (SMLM) to determine how the clathrin endocytosis inhibitors pitstop 2, dynasore and Latrunculin A alter the morphology of clathrin-coated pits. Su...
Dynein-driven regulation of postsynaptic membrane architecture and synaptic function [0.03%]
Dynactin调控突触后膜结构及功能
Amanda L Neisch,Thomas Pengo,Adam W Avery et al.
Amanda L Neisch et al.
Cytoplasmic dynein is essential in motoneurons for retrograde cargo transport that sustains neuronal connectivity. Little, however, is known about dynein's function on the postsynaptic side of the circuit. Here we report distinct postsynapt...
Classification and characteristics of bacterial glycosaminoglycan lyases, and their therapeutic and experimental applications [0.03%]
糖胺聚糖裂解酶的分类、特性及其在治疗和实验中的应用
Ruyi Zou,Xiangyu Xu,Fuchuan Li
Ruyi Zou
Glycosaminoglycans (GAGs), as animal polysaccharides, are linked to proteins to form various types of proteoglycans. Bacterial GAG lyases are not only essential enzymes that spoilage bacteria use for the degradation of GAGs, but also valuab...
Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases [0.03%]
2024年阿尔卑斯山区盘状角蛋白疾病会议报告：盘状蛋白和相关疾病的进展与新兴话题
Jens Waschke,Masayuki Amagai,Christoph Becker et al.
Jens Waschke et al.
Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohe...
Mayte Bonilla-Quintana,Andrea Ghisleni,Nils C Gauthier et al.
Mayte Bonilla-Quintana et al.
The plasma membrane and the underlying skeleton form a protective barrier for eukaryotic cells. The molecular players forming this complex composite material constantly rearrange under mechanical stress. One of those molecules, spectrin, is...