Actin from within - how nuclear myosins and actin regulate nuclear architecture and mechanics [0.03%]
从内而至：核肌球蛋白和肌动蛋白如何调节核结构与力学
Marta Gawor,Lilya Lehka,Danielle Lambert et al.
Marta Gawor et al.
Over the past two decades, significant progress has been made in understanding mechanotransduction to the nucleus. Nevertheless, most research has focused on outside-in signalling orchestrated by external mechanical stimuli. Emerging eviden...
Tomohiro Yorimitsu,Ken Sato
Tomohiro Yorimitsu
Intrinsically disordered regions (IDRs) are known to sense the positive membrane curvature of vesicles and tubules. However, whether IDRs can sense the negative curvature of their luminal surfaces remains elusive. Here, we show that IDRs di...
The non-canonical Smoothened-AMPK axis regulates Smaug1 biomolecular condensates [0.03%]
非经典的Smoothened-AMPK轴调节Smaug1生物分子凝聚体
María Gabriela Thomas,Ana Julia Fernández-Alvarez,Macarena Giménez et al.
María Gabriela Thomas et al.
Biomolecular condensates (BMCs) emerge as important players in RNA regulation. The RNA binding protein Smaug forms cytosolic BMCs in mammals, insects and yeasts and affects mitochondrial function and/or responses to nutrient deprivation. He...
In quiescent G0 phase, Schizosaccharomyces pombe Mis4 ensures full nuclear separation during the subsequent M phase [0.03%]
在静止的G0期，Mis4确保了分裂后的细胞核完全分离
Michiko Suma,Orie Arakawa,Yuria Tahara et al.
Michiko Suma et al.
Evolutionarily conserved Mis4 establishes cohesion between replicated sister chromatids in vegetatively proliferating cells. In the fission yeast, Schizosaccharomyces pombe, defects in Mis4 lead to premature separation of sister chromatids,...
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease [0.03%]
淀粉样蛋白通过WNT5A-ROR2激活JNK信号通路以减少阿尔茨海默病中的突触形成
Kevin Fang,Ehsan Pishva,Thomas Piers et al.
Kevin Fang et al.
Wnt signalling is an essential signalling system in neurogenesis, with a crucial role in synaptic plasticity and neuronal survival, processes that are disrupted in Alzheimer's disease (AD). Within this network, the Wnt/β-catenin pathway ha...
TAZ (WWTR1) Interactome Analysis using nanotrap based affinity purification-mass spectrometry [0.03%]
基于纳米磁珠亲和纯化质谱的TAZ（WWTR1）相互作用蛋白质组分析研究
Jonathan Kelebeev,Anastasia MacKeracher,Tetsuaki Miyake et al.
Jonathan Kelebeev et al.
Characterization of protein interactions is a fundamental goal in the post-genomic era. Here, we document a generally applicable approach to identify cellular protein interactomes using a combination of nanobody based affinity purification ...
The dynamic crosstalk between cytoskeletal filaments regulates the cytoplasmic mechanics across the dorsoventral axis [0.03%]
细胞骨架细丝的动态相互作用调节背腹轴胞质力学
Dipanjan Ray,Deepak Kumar Sinha
Dipanjan Ray
The cytoplasm exhibits viscoelastic properties, displaying both solid and liquid-like behavior, and can actively regulate its mechanical attributes. The cytoskeleton is a major regulator among the numerous factors influencing cytoplasmic me...
Ground-state pluripotent stem cells are characterized by Rac1-dependent Cadherin-enriched F-actin Complexes [0.03%]
Rac1依赖的钙黏蛋白富集F肌动蛋白复合体是地面态多能干细胞的特征
Shiying Liu,Yue Meng,Xi Lan et al.
Shiying Liu et al.
Pluripotent Stem Cells (PSCs) exhibit extraordinary differentiation potential and are thus highly valuable cellular model systems. However, while different PSC types corresponding to distinct stages of embryogenesis have been in common use,...
Regulation of mitochondrial cristae organization by Myo19, Miro1/2 and Metaxin 3 [0.03%]
线粒体变形素Myo19、线粒体内膜GTP酶Miro1/2和代谢性连接蛋白MTX3调控线粒体内膜嵴结构的功能研究
Samruddhi S Shembekar,Petra Nikolaus,Ulrike Honnert et al.
Samruddhi S Shembekar et al.
The actin-based motor myosin-19 (Myo19) exerts force on mitochondrial membrane receptors Miro1/2, influencing endoplasmic reticulum (ER)-mitochondria contact sites and mitochondrial cristae structure. The Mitochondrial Intermembrane Bridgin...
Mitochondria-plasma membrane contact sites regulate the ER-mitochondria encounter structure [0.03%]
线粒体-胞浆膜接触位点调节内质网-线粒体的结合结构
Jason C Casler,Clare S Harper,Laura L Lackner
Jason C Casler
Cells form multiple, molecularly distinct membrane contact sites (MCSs) between organelles. Despite knowing the molecular identity of several of these complexes, little is known about how MCSs are coordinately regulated in space and time to...