Direct neutrophil and T cell contact with macrophages induces release of phagosomally processed PAMPs via eructophagy [0.03%]
中性粒细胞和T细胞与巨噬细胞的直接接触通过eructophagy诱导释放吞噬体加工的PAMPs
Jenny A Nguyen,Tanis L Orsetti,Philip Vernon et al.
Jenny A Nguyen et al.
Macrophages play a pivotal role in clearing debris and microbes from the microenvironment via phagocytosis and orchestrating local inflammation. While mostly understood to be through the synthesis and secretion of soluble mediators such as ...
Zhi Yang Tan,Shujun Cai,Saayli A Paithankar et al.
Zhi Yang Tan et al.
When starved of nitrogen, fission yeast Schizosaccharomyces pombe cells enter a quiescent "G0" state with smaller nuclei and transcriptional repression. The genomics of S. pombe G0 cells has been well studied, but much of its nuclear cell b...
TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth [0.03%]
内体上的TC10通过PAK2-JNK通路调节微管稳定和动态之间的局部平衡并促进轴突生长
Shingo Koinuma,Misa Miyaji,Suzuka Akiyama et al.
Shingo Koinuma et al.
The neuronal cytoskeleton comprises microtubules, actin filaments and neurofilaments, and plays a crucial role in axon outgrowth and transport. Microtubules and actin filaments have attracted considerable attention in axon regeneration stud...
Renata Basto
Renata Basto
Exploiting the SunTag system to study the developmental regulation of mRNA translation [0.03%]
利用SunTag系统研究mRNA翻译的发育调控
Alastair Pizzey,Catherine Sutcliffe,Jennifer C Love et al.
Alastair Pizzey et al.
The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of translation regulation in Drosophila. Repressi...
The formation of chaperone-rich GET bodies depends on the tetratricopeptide repeat region of Sgt2 and is reversed by NADH [0.03%]
富含分子伴侣的GET结构体的形成依赖于Sgt2的四肽重复序列区域，并可被NADH逆转
Jonas Jennrich,Ákos Farkas,Henning Urlaub et al.
Jonas Jennrich et al.
The guided-entry of tail-anchored proteins (GET) pathway is a post-translational targeting route to the endoplasmic reticulum. Upon glucose withdrawal, the soluble GET proteins re-localize to dynamic cytosolic foci, here termed GET bodies. ...
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction [0.03%]
内质网在机械感知和机械转导中的新兴作用
Jonathan Townson,Cinzia Progida
Jonathan Townson
Cells are continuously subjected to physical and chemical cues from the extracellular environment, and sense and respond to mechanical cues via mechanosensation and mechanotransduction. Although the role of the cytoskeleton in these process...
Dachsous is a key player in epithelial wound closure by modulating cell shape changes and tissue mechanics [0.03%]
Dachsous通过调节细胞形状变化和组织力学在上皮伤口闭合中扮演关键角色
Patrícia Porfírio-Rodrigues,Telmo Pereira,Antonio Jacinto et al.
Patrícia Porfírio-Rodrigues et al.
Epithelia are vital tissues in multicellular organisms, acting as barriers between external and internal environments. Simple epithelia, such as pg those in embryos and the adult gut, have the remarkable ability to repair wounds efficiently...
Saanjbati Adhikari,Seema Grewal
Saanjbati Adhikari
Emma J van Grinsven,Anna Akhmanova
Emma J van Grinsven
Microtubules are cytoskeletal filaments important for various cellular processes such as intracellular transport, cell division, polarization and migration. Microtubule organization goes hand in hand with cellular function. Motile cells, su...