Yu Sun,Aaron J Hamlin,Jean E Schwarzbauer
Yu Sun
The organization and mechanics of extracellular matrix (ECM) protein polymers determine tissue structure and function. Secreted ECM components are assembled into polymers via a cell-mediated process. The specific mechanisms that cells use f...
Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration [0.03%]
Rab40鸟苷三磷酸酶调节AMBRA1介导的转录和细胞迁移
Revathi Sampath,Katherine Vaeth,Valeryia Mikalayeva et al.
Revathi Sampath et al.
The Rab40 subfamily are unique small monomeric GTPases that form CRL5-based ubiquitin E3 ligase complex and regulate ubiquitylation of specific target proteins. Recent studies have shown that Rab40s play an important role in regulating cell...
Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling [0.03%]
初级纤毛通过刺猬信号通路影响出生后星形胶质细胞的发育
Rachel Bear,Steven A Sloan,Tamara Caspary
Rachel Bear
Primary cilia function as specialized signaling centers that regulate many cellular processes including neuron and glia development. Astrocytes possess cilia, but the function of cilia in astrocyte development remains largely unexplored. Cr...
Co-transcriptional splicing is delayed in the highly expressed thyroglobulin gene [0.03%]
甲状腺球蛋白基因的共转录剪接是高度表达的基因且被延迟了
Simon Ullrich,Iliya Nadelson,Stefan Krebs et al.
Simon Ullrich et al.
Transcription of the majority of eukaryotic genes is accompanied by splicing. The timing of splicing varies significantly between introns, transcripts, genes and species. Although quick co-transcriptional intron removal has been demonstrate...
Mónica Bettencourt-Dias,Amy Gladfelter,Gautam Dey et al.
Mónica Bettencourt-Dias et al.
Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein [0.03%]
人类线粒体TOM相互作用组的定义揭示了TRABD作为新的互作蛋白
Metin Özdemir,Silke Oeljeklaus,Schendzielorz Alexander et al.
Metin Özdemir et al.
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial ...
Sukrut C Kamerkar,Ao Liu,Henry N Higgs
Sukrut C Kamerkar
Mitochondrial fission is important for many aspects of cellular homeostasis, including mitochondrial distribution, stress response, mitophagy, mitochondrially derived vesicle production and metabolic regulation. Several decades of research ...
The Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane [0.03%]
Mia40底物Mix17将其N端暴露于线粒体外膜的细胞质侧
Moritz Resch,Johanna S Frickel,Korbinian Dischinger et al.
Moritz Resch et al.
Mitochondrial architecture and the contacts between the outer and the inner mitochondrial membrane depend on the mitochondrial contact site and cristae organizing system (MICOS) that is highly conserved from yeast to human. Mutations in the...
Practical recommendations for developing software for life science applications [0.03%]
为生命科学应用开发软件的实际建议
Joanna W Pylvänäinen,Guillaume Jacquemet,Stefania Marcotti
Joanna W Pylvänäinen
Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scientists presents challenges to software adoption. I...
Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces [0.03%]
Formin 3 稳定果蝇肌腱细胞的细胞骨架，从而使它们能够抵抗肌肉张力
Helena Pissarek,Na Huang,Leanna H Frasch et al.
Helena Pissarek et al.
The cytoskeleton of Drosophila tendon cells features specialized F-actin/microtubule arrays that endow these cells with resistance to the tensile forces exerted by the attached muscles. In a forward genetic screen for mutants with neuromusc...