A novel approach to tagging tubulin reveals MT assembly dynamics of the axoneme in Trypanosoma brucei [0.03%]
一种新的蛋白标记方法揭示了布鲁里冈布亚锥虫轴突膜微管组装动力学机制
Daniel Abbühl,Martina Pružincová,Luděk Štěpánek et al.
Daniel Abbühl et al.
The protozoan parasite Trypanosoma brucei assembles a new flagellum while maintaining the existing one in the same cell. Our group proposed a model where the mature flagellum is locked after construction to full length (Bertiaux et al. 2018...
Resolution in super-resolution microscopy - facts, artifacts, technological advancements and biological applications [0.03%]
超分辨率显微镜的分辨率：事实、技术改进和生物应用
Kirti Prakash,David Baddeley,Christian Eggeling et al.
Kirti Prakash et al.
Super-resolution microscopy (SRM) has undeniable potential for scientific discovery, yet still presents many challenges that hinder its widespread adoption, including technical trade-offs between resolution, speed and photodamage, as well a...
SAXO proteins mediate tubulin turnover in axonemal microtubules of Chlamydomonas [0.03%]
藻蓝蛋白介导衣藻轴丝微管中微管蛋白的周转
Yongli Zhang,Xuecheng Li,Zhengmao Wang et al.
Yongli Zhang et al.
Cilia and eukaryotic flagella are microtubule-based organelles crucial for cell motility and signaling. SAXO proteins (stabilizers of axonemal microtubules) are found exclusively in flagellated or ciliated organisms, but their physiological...
Skeletal ciliopathy variants of dynein-2 DYNC2LI1 subunit impair osteogenic differentiation of mesenchymal stem cells [0.03%]
DYNC2LI1突变通过干扰间充质干细胞成骨分化导致骨骼鞭毛病表型
Yamato Ishida,Haruka Hoshi,Kenichi Kawano et al.
Yamato Ishida et al.
Skeletal ciliopathies result from defects in primary cilia, which are crucial for embryonic development through transduction of extracellular signals, including Hedgehog. Selective transport of ciliary proteins is mediated by the intraflage...
Correction: Defining the dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae [0.03%]
订正：发表关于来自梅氏红球藻的过氧化物酶体分裂装置中基于动力蛋白的环状组装中心的定义论文
Yuuta Imoto,Yuichi Abe,Kanji Okumoto et al.
Yuuta Imoto et al.
Published Erratum
Journal of cell science. 2025 May 15;138(10):jcs264019. DOI:10.1242/jcs.264019 2025
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and IFT machinery [0.03%]
β- arrestin介导GPR161（而非Smoothened）与BBSome和IFT装置一起输出到纤毛中
Taiju Fujii,Norihito Murai,Shinya Aso et al.
Taiju Fujii et al.
Specific G protein-coupled receptors (GPCRs) exist on the ciliary membrane. Hedgehog signaling activation triggers the import of Smoothened into and export of GPR161 from cilia. The BBSome comprising eight Bardet-Biedl syndrome (BBS) protei...
Glutamine modulates stress granule formation in cancer cells through core RNA-binding proteins [0.03%]
谷氨酰胺通过核心RNA结合蛋白调节癌细胞中的应激颗粒形成
Gabriel P Faber,Gilad Gross,Oz Mualem et al.
Gabriel P Faber et al.
Cytoplasmic stress granules (SGs) induced by various stresses have been linked to cancer and other disorders. Which active energy pathways are required for SG formation remains unclear. We used nutrient deprivation to show that glutamine is...
A data-driven model for mitochondrial inner membrane remodeling as a driving force of organelle shaping [0.03%]
一种数据驱动模型：线粒体内膜重塑是 Organelle 形态形成的驱动力
Noga Preminger,Ben Zucker,Sarah Hassdenteufel et al.
Noga Preminger et al.
Mitochondria are dynamic organelles exhibiting diverse shapes. While the variation of shapes, ranging from spheres to elongated tubules, and the transition between them, are clearly seen in many cell types, the molecular mechanisms governin...
Snapshots of mitochondrial fission imaged by cryo-scanning transmission electron tomography [0.03%]
低温扫描传输电子层析成像法观测线粒体分裂的图像
Peter Kirchweger,Sharon Grayer Wolf,Neta Varsano et al.
Peter Kirchweger et al.
Mitochondria undergo constant remodeling via fission, fusion, extension and degradation. Fission, in particular, depends on the accumulation of mitochondrial fission factor (MFF) and subsequent recruitment of the dynamin-related protein DRP...
Antigoni Diokmetzidou,Luca Scorrano
Antigoni Diokmetzidou
Mitochondrial contact sites are specialized interfaces where mitochondria physically interact with other organelles. Stabilized by molecular tethers and defined by unique proteomic and lipidomic profiles, these sites enable direct interorga...