CCDC86 is a novel Ki-67-interacting protein important for cell division [0.03%]
CCDC86是一种新的Ki-67相互作用蛋白，对细胞分裂很重要
Konstantinos Stamatiou,Aldona Chmielewska,Shinya Ohta et al.
Konstantinos Stamatiou et al.
The chromosome periphery is a network of proteins and RNAs that coats the outer surface of mitotic chromosomes. Despite the identification of new components, the functions of this complex compartment are poorly characterised. In this study,...
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis [0.03%]
细胞质膜内的二酰甘油促进封闭分裂中核包膜的扩张
Sherman Foo,Amaury Cazenave-Gassiot,Markus R Wenk et al.
Sherman Foo et al.
Nuclear envelope (NE) expansion must be controlled to maintain nuclear shape and function. The nuclear membrane expands massively during closed mitosis, enabling chromosome segregation within an intact NE. Phosphatidic acid (PA) and diacylg...
Marieke M Glazenburg,Liedewij Laan
Marieke M Glazenburg
Cellular life exhibits order and complexity, which typically increase over the course of evolution. Cell polarization is a well-studied example of an ordering process that breaks the internal symmetry of a cell by establishing a preferentia...
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms [0.03%]
Scribble和E-钙粘素通过多种机制共同控制对称子细胞定位
Anchi S Chann,Ye Chen,Tanja Kinwel et al.
Anchi S Chann et al.
The fate of the two daughter cells is intimately connected to their positioning, which is in turn regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple cues are integrated to dictate the ultimate positi...
Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder [0.03%]
从KIF1A相关神经障碍研究中对轴突运输调控的了解
Kyoko Chiba,Tomoki Kita,Yuzu Anazawa et al.
Kyoko Chiba et al.
Neuronal function depends on axonal transport by kinesin superfamily proteins (KIFs). KIF1A is the molecular motor that transports synaptic vesicle precursors, synaptic vesicles, dense core vesicles and active zone precursors. KIF1A is regu...
Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding [0.03%]
ERp57和ERdj5在内质网蛋白折叠过程中的分离异构酶和还原酶作用中的不同作用
Philip John Robinson,Marie Anne Pringle,Bethany Fleming et al.
Philip John Robinson et al.
Proteins entering the secretory pathway need to attain native disulfide pairings to fold correctly. For proteins with complex disulfides, this process requires the reduction and isomerisation of non-native disulfides. Two key members of the...
The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase [0.03%]
kinesin-5蛋白Cut7在有丝分裂后期活性增强，沿裂殖酵母纺锤体双向移动
Zachary R Gergely,Saad Ansari,Michele H Jones et al.
Zachary R Gergely et al.
Kinesin-5 motors are essential to separate mitotic spindle poles and assemble a bipolar spindle in many organisms. These motors crosslink and slide apart antiparallel microtubules via microtubule plus-end-directed motility. However, kinesin...
Field model for multistate lateral diffusion of various transmembrane proteins observed in living Dictyostelium cells [0.03%]
活的Dictyostelium细胞中各种跨膜蛋白多状态横向扩散的场模型
Kazutoshi Takebayashi,Yoichiro Kamimura,Masahiro Ueda
Kazutoshi Takebayashi
The lateral diffusion of transmembrane proteins on plasma membranes is a fundamental process for various cellular functions. Diffusion properties specific for individual protein species have been extensively studied, but the common features...
The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery [0.03%]
货物受体Erv14的C端影响COPII有被小泡的形成及货物运送
Daniel Lagunas-Gomez,Carolina Yañez-Dominguez,Guadalupe Zavala-Padilla et al.
Daniel Lagunas-Gomez et al.
The endoplasmic reticulum (ER) is the start site of the secretory pathway, where newly synthesized secreted and membrane proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo rec...
Three's a crowd - why did three N-terminal methyltransferases evolve for one job? [0.03%]
三个太多 - 为什么会有三种N端甲基转移酶来完成同一份工作？
Meghan M Conner,Christine E Schaner Tooley
Meghan M Conner
N-terminal methylation of the α-amine group (Nα-methylation) is a post-translational modification (PTM) that was discovered over 40 years ago. Although it is not the most abundant of the Nα-PTMs, there are more than 300 predicted substra...