Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition [0.03%]
flotillin和鞘氨醇激酶2的上调通过促进AXL囊泡运输异常来诱导上皮间质转化
Mallory Genest,Franck Comunale,Damien Planchon et al.
Mallory Genest et al.
Altered endocytosis and vesicular trafficking are major players during tumorigenesis. Flotillin overexpression, a feature observed in many invasive tumors and identified as a marker of poor prognosis, induces a deregulated endocytic and tra...
Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish [0.03%]
TPC1介导的端 lysosome 中钙的局部释放对斑马鱼肌节连接发育有贡献
Keira L Rice,Sarah E Webb,Andrew L Miller
Keira L Rice
In the trunk of developing zebrafish embryos, adjacent myotome blocks transmit contractile force via myoseptal junctions (MJs), which are dynamic structures that connect the actin cytoskeleton of skeletal muscle cells to extracellular matri...
Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers [0.03%]
β2m解离诱导非共价经典的MHC I分子二聚体形成
Cindy Dirscherl,Sara Löchte,Zeynep Hein et al.
Cindy Dirscherl et al.
At the plasma membrane of mammalian cells, major histocompatibility complex class I molecules (MHC-I) present antigenic peptides to cytotoxic T cells. Following the loss of the peptide and the light chain beta-2 microglobulin (β2m, encoded...
Dopey proteins are essential but overlooked regulators of membrane trafficking [0.03%]
具有功能性障碍的蛋白是膜转运的重要调控因子不容忽视
Adrian Molière,Katharina B Beer,Ann M Wehman
Adrian Molière
Dopey family proteins play crucial roles in diverse processes from morphogenesis to neural function and are conserved from yeast to mammals. Understanding the mechanisms behind these critical functions could have major clinical significance...
Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography [0.03%]
运用冷冻电子断层扫描技术观察神经生长锥细胞骨架机器结构
Joseph Atherton,Melissa Stouffer,Fiona Francis et al.
Joseph Atherton et al.
Neurons extend axons to form the complex circuitry of the mature brain. This depends on the coordinated response and continuous remodelling of the microtubule and F-actin networks in the axonal growth cone. Growth cone architecture remains ...
Regulation of microtubule detyrosination by Ca2+ and conventional calpains [0.03%]
钙离子和常规卡巴蛋白对微管去酪氨酸化的调节作用
Julia Bär,Yannes Popp,Tomas Koudelka et al.
Julia Bär et al.
Detyrosination is a major post-translational modification of microtubules (MTs), which has significant impact on MT function in cell division, differentiation, growth, migration and intracellular trafficking. Detyrosination of α-tubulin oc...
Centrosome maturation requires phosphorylation-mediated sequential domain interactions of SPD-5 [0.03%]
中心体成熟需要SPD-5的磷酸化介导的连续域相互作用
Momoe Nakajo,Hikaru Kano,Kenji Tsuyama et al.
Momoe Nakajo et al.
Centrosomes consist of two centrioles and the surrounding pericentriolar material (PCM). The PCM expands during mitosis in a process called centrosome maturation, in which PCM scaffold proteins play pivotal roles to recruit other centrosoma...
Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments [0.03%]
核硬化素调节核硬度以在封闭环境中实现快速变形虫样迁移essential
Sandrine B Lavenus,Karl W Vosatka,Alexa P Caruso et al.
Sandrine B Lavenus et al.
When metastasizing, tumor cells must traverse environments with diverse physicochemical properties. Recently, the cell nucleus has emerged as a major regulator of the transition from mesenchymal to fast amoeboid (leader bleb-based) migratio...
Annexin A2 and Ahnak control cortical NuMA-dynein localization and mitotic spindle orientation [0.03%]
annexin a2 和 ahnak 控制皮层 NuMA-动力蛋白定位及有丝分裂纺锤体取向
Aude Pascal,Emmanuel Gallaud,Regis Giet et al.
Aude Pascal et al.
Proper mitotic spindle orientation depends on the correct anchorage of astral microtubules to the cortex. It relies on the remodeling of the cell cortex, a process not fully understood. Annexin A2 (Anx2; also known as ANXA2) is a protein kn...
A PKC that controls polyphosphate levels, pinocytosis and exocytosis, regulates stationary phase onset in Dictyostelium [0.03%]
Dictyostelium中一个控制多磷酸盐水平、胞饮和分泌的PKC调节静止期的发生
Shalini Umachandran,Wasima Mohamed,Meenakshi Jayaraman et al.
Shalini Umachandran et al.
Many cells can pause their growth cycle, a topic much enriched by studies of the stationary phase (SP) of model microorganisms. Although several kinases are implicated in SP onset, whether protein kinase C has a role remains unknown. We sho...