Matrix stiffness regulates Notch signaling activity in endothelial cells [0.03%]
基质刚度调节内皮细胞中Notch信号活性
Maibritt Kretschmer,Rose Mamistvalov,David Sprinzak et al.
Maibritt Kretschmer et al.
Notch signaling is critical for many developmental and disease-related processes. It is widely accepted that Notch has a mechanotransduction module that regulates receptor cleavage. However, the role of biomechanical properties of the cellu...
Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation [0.03%]
单个染色体动态揭示位点依赖性动态和染色体区域取向
Yu-Chieh Chung,Madhoolika Bisht,Jenna Thuma et al.
Yu-Chieh Chung et al.
Dynamic chromatin organization instantly influences DNA accessibility through modulating local macromolecular density and interactions, driving changes in transcription activities. Chromatin dynamics have been reported to be locally confine...
Preferential recruitment and stabilization of Myosin II at compartment boundaries in Drosophila [0.03%]
模式生物中肌球蛋白-II在细胞器边界的优先募集及稳定化机制研究
Jing Wang,Marcus Michel,Lisa Bialas et al.
Jing Wang et al.
The regulation of mechanical tension exerted at cell junctions guides cell behavior during tissue formation and homeostasis. Cell junctions along compartment boundaries, which are lineage restrictions separating cells with different fates a...
Toxoplasma gondii scavenges mammalian host organelles through the usurpation of host ESCRT-III and Vps4A [0.03%]
托氏子孢子虫通过劫持宿主ESCRT-III和Vps4A蛋白复合物获取宿主公溶体及线粒体等细胞器
Julia D Romano,Joshua Mayoral,Rebekah B Guevara et al.
Julia D Romano et al.
Intracellular pathogens exploit cellular resources through host cell manipulation. Within its nonfusogenic parasitophorous vacuole (PV), Toxoplasma gondii targets host nutrient-filled organelles and sequesters them into the PV through deep ...
Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress [0.03%]
在丝氨酸22处的Lamin A/C磷酸化是一种保守的热休克反应，以调节压力期间的核适应
Laura Virtanen,Emilia Holm,Mona Halme et al.
Laura Virtanen et al.
The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by the LMNA gene, contributes towards altered gene expression during HS, but the underlying mechanisms are poorly understood. Here...
Michael Way
Michael Way
CCDC86 is a novel Ki-67-interacting protein important for cell division [0.03%]
CCDC86是一种新的Ki-67相互作用蛋白，对细胞分裂很重要
Konstantinos Stamatiou,Aldona Chmielewska,Shinya Ohta et al.
Konstantinos Stamatiou et al.
The chromosome periphery is a network of proteins and RNAs that coats the outer surface of mitotic chromosomes. Despite the identification of new components, the functions of this complex compartment are poorly characterised. In this study,...
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis [0.03%]
细胞质膜内的二酰甘油促进封闭分裂中核包膜的扩张
Sherman Foo,Amaury Cazenave-Gassiot,Markus R Wenk et al.
Sherman Foo et al.
Nuclear envelope (NE) expansion must be controlled to maintain nuclear shape and function. The nuclear membrane expands massively during closed mitosis, enabling chromosome segregation within an intact NE. Phosphatidic acid (PA) and diacylg...
Marieke M Glazenburg,Liedewij Laan
Marieke M Glazenburg
Cellular life exhibits order and complexity, which typically increase over the course of evolution. Cell polarization is a well-studied example of an ordering process that breaks the internal symmetry of a cell by establishing a preferentia...
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms [0.03%]
Scribble和E-钙粘素通过多种机制共同控制对称子细胞定位
Anchi S Chann,Ye Chen,Tanja Kinwel et al.
Anchi S Chann et al.
The fate of the two daughter cells is intimately connected to their positioning, which is in turn regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple cues are integrated to dictate the ultimate positi...