Phagocytosis at a glance [0.03%]
吞噬作用要点概览图
Manon Depierre,Chiara Pompili,Florence Niedergang
Manon Depierre
Phagocytosis functions as the internalisation mechanism responsible for engulfing large particles, microorganisms and cellular debris. It relies on specific cell surface receptors to induce membrane deformation, extension and contraction fo...
Chemically tunable FOXM1-D sensor revealed FOXM1 direct influence on cell cycle [0.03%]
化学可调的FOXM1-D传感器揭示了FOXM1对细胞周期的直接影响
Kriengkrai Phongkitkarun,Porncheera Chusorn,Maliwan Kamkaew et al.
Kriengkrai Phongkitkarun et al.
Forkhead box protein M1 (FOXM1) is a transcription factor required for the G2/M transition and is frequently upregulated in cancers, promoting tumor progression and therapy resistance. However, its dynamic regulation throughout the cell cyc...
Transmembrane protein 184B (TMEM184B) modulates endolysosomal acidification via the vesicular proton pump [0.03%]
跨膜蛋白184B(TMEM184B)通过溶酶体质子泵调节内噬溶酶体酸化
Elizabeth B Wright,Erik G Larsen,Marco Padilla-Rodriguez et al.
Elizabeth B Wright et al.
Disruption of endolysosomal acidification causes toxic protein accumulation and neuronal dysfunction linked to neurodevelopmental and neurodegenerative disorders. However, the molecular mechanisms regulating neuronal endolysosomal pH remain...
14-3-3ɛ inhibits premature centriole disengagement by inhibiting the activity of Plk1 and Separase [0.03%]
14-3-3蛋白ɛ通过抑制PLK1和分离酶的活性来阻止中心粒过早脱离
Monika A Jaiswal,Akshay Karn,Aparna Das et al.
Monika A Jaiswal et al.
The 14-3-3 protein family regulates several pathways in mammalian cells, including centrosome duplication. However, the precise mechanisms by which 14-3-3 paralogs regulate the centrosome cycle remain unclear. To identify the mechanisms by ...
The scaffold protein CasL restrains membrane blebbing and promotes T cell migration [0.03%]
支架蛋白CasL限制细胞膜芽状突起的形成并促进T细胞迁移
Liz A Kurtz,Hope E Shearer,Rosanne Trevail et al.
Liz A Kurtz et al.
T cell migration into inflamed tissue is a key control point in the inflammatory response and relies on integrin interactions with their endothelial ligands. Here, we identify the signaling scaffold CasL (Hef1, NEDD9) as a central regulator...
Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1 [0.03%]
酵母菌中杀伤毒素K28耐受性依赖于COG复合物介导的防御因子Ktd1转运过程
Kamilla M E Laidlaw,Hatwan H Nadir,Amy Milburn et al.
Kamilla M E Laidlaw et al.
A/B toxins are a diverse family of protein toxins that enter host cells via endocytosis and induce cell death. In yeast, the A/B toxin K28 is internalised to endosomes of susceptible yeast, before following the retrograde trafficking pathwa...
Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model [0.03%]
Hedgehog信号传导的抑制不会缓解PKD1突变体小鼠模型多囊性肾脏病的严重程度
Sean Gombart,Scott Houghtaling,Tzu-Hua Ho et al.
Sean Gombart et al.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disorder caused by mutations in PKD1 or PKD2, encoding polycystin-1 and polycystin-2, respectively. These polycystins form a cilia-localized complex that, when mutated, fai...
Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against MCM reloading and tetraploidy [0.03%]
一种依赖于蛋白酶体的Orc6从染色质上移除机制在S期开始时防止了MCM重组及染色体四倍体的产生
Yoko Hayashi-Takanaka,Ichiro Hiratani,Tokuko Haraguchi et al.
Yoko Hayashi-Takanaka et al.
DNA replication is tightly regulated to occur only once per cell cycle, as untimely re-initiation can lead to aneuploidy, which is associated with early senescence and cancer. The pre-replication complex (comprising Orc1-6, Cdc6, Cdt1, and ...
ATP synthase epsilon subunit: An unconventional adaptor of clathrin-mediated endocytosis of hemoglobin in Leishmania [0.03%]
顶体蛋白合成酶epsilon亚基：莱什曼原虫血红蛋白网格蛋白依赖性内吞作用的非常规衔接子
Anjali Kapoor,Jitender Kumar Verma,Deepali Goyal et al.
Anjali Kapoor et al.
In clathrin-mediated endocytosis, cytoplasmic domain of the receptor binds with AP2-adaptor which recruits clathrin to mediate endocytosis. Classical AP2-adaptor Leishmania is not yet characterized. Here, we have identified ATP Synthase eps...
A role for class I p21-activated kinases in the regulation of the excitability of the actin cytoskeleton [0.03%]
一类p21活化激酶在调节肌动蛋白细胞骨架兴奋性中的作用
Joe J Tyler,Anthony Davidson,Megan E Poxon et al.
Joe J Tyler et al.
The p21-activated kinases (PAKs) are involved in a range of functions, including the regulation of the actin cytoskeleton. However, although many PAK substrates identified have been implicated in the regulation of the actin cytoskeleton, a ...