DySTrack: a modular smart microscopy tool for live tracking of dynamic samples on modern commercial microscopes [0.03%]
DySTrack：一种模块化的智能显微镜工具可对现代商业显微镜上的动态样品进行实时跟踪
Zimeng Wu,Octavian Voiculescu,Alessandro Mongera et al.
Zimeng Wu et al.
Advances in microscopy and bioimage analysis are enabling unprecedented quantitative observation of dynamic biological systems. Smart microscopy closes the loop by feeding back image-derived information to control image acquisition on the f...
Complementary volume electron microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges [0.03%]
互补的体电子显微镜方法揭示了生殖细胞间桥连接的超微结构变化
Irina Kolotuev,Sophie Khazanov,Abigayle Williams et al.
Irina Kolotuev et al.
The Drosophila melanogaster egg chamber is a powerful model system to study germline intercellular bridges, or ring canals, which connect the developing oocyte to supporting nurse cells. Despite their importance, it is technically difficult...
Temperature-specific regulation of the NDR kinase Orb6 by the MAPK Sty1 to promote heat stress resilience [0.03%]
MAPK Sty1通过温度特异性调节NDR激酶Orb6来增强热胁迫耐受性
Laura P Doyle,Robert N Tams,Chuan Chen et al.
Laura P Doyle et al.
The cellular response to environmental fluctuations, such as increased temperature, is crucial in promoting cell survival and plays an increasingly recognized role in cancer biology. Important cellular functions altered by heat stress are c...
Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function [0.03%]
焦磷酸法尼基化前体突变核纤层蛋白通过抑制nesprin-2-SUN2大型胞质衔接复合物的功能引起早衰症成纤维细胞极性缺陷
Chonkit Lio,Yuexia Wang,Paige C Wilson et al.
Chonkit Lio et al.
Disrupted processing of prelamin A causes Hutchinson-Gilford progeria syndrome (HGPS) and related premature aging disorders. The farnesylated prelamin A variant produced in HGPS, termed progerin, alters actin-nuclear interactions mediated b...
Regulation of Citron kinase by CDK1 and Aurora B regulates midbody formation and stability [0.03%]
CDK1和Aurora B对Citron激酶的调节控制中体的形成与稳定性
Luisa Capalbo,Ella F J Halcrow,Zuni I Bassi et al.
Luisa Capalbo et al.
Many cell division events are regulated by protein phosphorylation, which can result from cross-regulatory mechanisms among mitotic kinases and phosphatases that have yet to be fully elucidated. Here, we report the characterization of a nov...
Molecular features of myosin F adapted for driving actin flows in Toxoplasma gondii [0.03%]
托拉川吸虫肌球蛋白F适应驱动肌动蛋白流的分子特征
Thomas E Sladewski,Aoife T Heaslip
Thomas E Sladewski
Toxoplasma gondii is a single-celled apicomplexan parasite that relies on a highly polarized endomembrane system for its invasion of, and survival within, host cells. Recent advances in imaging technologies have revealed that vesicle transp...
GAK antagonises ROCK-dependent regulation of actomyosin dynamics [0.03%]
GAK对抗ROCK依赖的肌动蛋白肌球蛋白动力学调节作用
Masaki Hiramoto,Naoharu Takano,Hiroko Kokuba et al.
Masaki Hiramoto et al.
Cytoskeletal proteins, such as actin and myosin, are essential for regulating cell morphology and motility. Rho-associated kinase (ROCK; herein referring collectively to ROCK1 and ROCK2) is a key regulator of actomyosin dynamics, including ...
Gina Simon,Savina Abraham Pol,Melisa Dendusic et al.
Gina Simon et al.
Cellular stress response pathways support cell survival under stress and are often leveraged by cancer cells to gain advantageous traits. How cells respond to Golgi apparatus (Golgi) stress is incompletely understood, limiting insights into...
Sensing of shear stress in vascular endothelial cells - from physiology to pathology [0.03%]
血管内皮细胞剪切应力感受的生理和病理学研究进展
Eulashini Chuntharpursat-Bon,Jovana Serbanovic-Canic,Mabruka Alfaidi et al.
Eulashini Chuntharpursat-Bon et al.
Sensing of mechanical force is crucial in regulating vascular homeostasis, physiology and disease. Endothelial cells line the lumens of blood vessels and are constantly exposed to flowing blood. This generates mechanical shear stress, which...
Marintia M Nava-García,Sonakshi Gehlot,Wing-Yan Skyla Siu et al.
Marintia M Nava-García et al.
Although research on the nucleus has historically focused on proteins and nucleic acids, the crucial roles of lipids in nuclear biology have remained underappreciated. Lipids are not merely structural components but are now understood to be...