GAK antagonises ROCK-dependent regulation of actomyosin dynamics [0.03%]
GAK对抗ROCK依赖的肌动蛋白肌球蛋白动力学调节作用
Masaki Hiramoto,Naoharu Takano,Hiroko Kokuba et al.
Masaki Hiramoto et al.
Cytoskeletal proteins, such as actin and myosin, are essential for regulating cell morphology and motility. Rho-associated kinase (ROCK; herein referring collectively to ROCK1 and ROCK2) is a key regulator of actomyosin dynamics, including ...
Gina Simon,Savina Abraham Pol,Melisa Dendusic et al.
Gina Simon et al.
Cellular stress response pathways support cell survival under stress and are often leveraged by cancer cells to gain advantageous traits. How cells respond to Golgi apparatus (Golgi) stress is incompletely understood, limiting insights into...
Sensing of shear stress in vascular endothelial cells - from physiology to pathology [0.03%]
血管内皮细胞剪切应力感受的生理和病理学研究进展
Eulashini Chuntharpursat-Bon,Jovana Serbanovic-Canic,Mabruka Alfaidi et al.
Eulashini Chuntharpursat-Bon et al.
Sensing of mechanical force is crucial in regulating vascular homeostasis, physiology and disease. Endothelial cells line the lumens of blood vessels and are constantly exposed to flowing blood. This generates mechanical shear stress, which...
Marintia M Nava-García,Sonakshi Gehlot,Wing-Yan Skyla Siu et al.
Marintia M Nava-García et al.
Although research on the nucleus has historically focused on proteins and nucleic acids, the crucial roles of lipids in nuclear biology have remained underappreciated. Lipids are not merely structural components but are now understood to be...
Outer kinetochore proteins form linear elements to regulate vesicle transport [0.03%]
外侧动粒蛋白形成线性结构调节囊泡运输
Shane J Kowaleski,Alexis Bridgewater,Cody Saraceno et al.
Shane J Kowaleski et al.
During cell division, several key regulators of chromosome segregation play additional roles during vesicle trafficking required for cytokinesis. During anaphase I in C. elegans oocytes, chromosome segregation is coordinated with vesicle tr...
Xiang Cui,Liao Yang,Huali Zhang et al.
Xiang Cui et al.
Paraptosis is a distinct form of programmed cell death characterized by extensive cytoplasmic vacuolation, endoplasmic reticulum (ER) dilation, and mitochondrial swelling. While previous studies have focused primarily on the ER and mitochon...
A ULK1-MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis [0.03%]
ULK1-MTFR1L反馈回路连接线粒体分裂、自噬和凋亡
Riccardo Babic,Leon Lucya,Christoph Reiter et al.
Riccardo Babic et al.
Mitophagy, the selective degradation of damaged mitochondria, preserves mitochondrial quality, yet how mitochondrial fission is coordinated with autophagy initiation remains unclear. Here we identify the mitochondrial outer membrane protein...
The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in drosophila [0.03%]
参与果蝇树突及突触修剪的信使rna转运因子UAP56
Samuel Matthew Frommeyer,Ulrike Gigengack,Sandra Rode et al.
Samuel Matthew Frommeyer et al.
Neurite and synapse pruning are conserved mechanisms that adapt neuronal circuitry to different developmental stages. Drosophila sensory c4da neurons prune their larval dendrites and their presynaptic terminals during metamorphosis using a ...
Baicong Mu,Dan Zhang
Baicong Mu
Membrane integrity is vital for cell survival and function. Despite constant mechanical and chemical challenges, cellular membranes exhibit remarkable resilience through highly coordinated protective and repair mechanisms. Here, we outline ...
Biophysical and biochemical studies support PHD inhibitor development as a TPI deficiency therapy [0.03%]
生物物理和生化研究支持PHD抑制剂开发作为TPI缺乏症治疗手段
Presley Roberts,Joseph R Figura,Kaitlin McClure et al.
Presley Roberts et al.
Triosephosphate isomerase deficiency (TPI Df) is an ultra-rare genetic enzymopathy. Previously, the TPIR5G allele was found to cause TPI Df when combined with a null allele. Here we report a 1.15 angstrom TPIR5G crystal structure providing ...