SBIS, a new orange fluorescent vital probe for the 4D imaging of brown algal cells [0.03%]
一种新的橙色荧光活细胞探针SBIS用于褐藻细胞的四维成像研究
Marie Zilliox,Mayeul Collot,Bénédicte Charrier
Marie Zilliox
Living cells of brown algae are difficult to observe in 3D because pigments such as fucoxanthin and chlorophyll diffract light. Furthermore, at the beginning of their life, brown algae develop slowly in seawater. To gain insight into the 3D...
Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation [0.03%]
与核脂滴形成相关的Fanconi贫血蛋白D2的动力学
Tomoya Hotani,Motonari Goto,Yukie Otsuki et al.
Tomoya Hotani et al.
Fanconi anemia is a rare genetic disease caused by the loss of function of one of the 23 associated genes and is characterized by bone marrow failure, cancer predisposition, and developmental defects. The proteins encoded by these genes (FA...
Béla Novák (1956-2025) - a legacy of scientific discovery and personal charm [0.03%]
贝拉·诺瓦克（1956-2025）——科学发现和个人魅力的遗产
Alexis R Barr,Francis A Barr,John J Tyson
Alexis R Barr
Toggle-Untoggle: A cell segmentation tool with an interactive user verification interface [0.03%]
一键切换：一种具备互动用户验证界面的细胞分割工具
Nina Grishchenko,Margarita Byrsan,Matthew Craig Drummond-Stoyles et al.
Nina Grishchenko et al.
Accurate cell segmentation is an essential step in the quantitative analysis of fluorescence microscopy images. Pre-trained deep learning models for automatic cell segmentation such as those offered by Cellpose perform well across a variety...
Characterisation of primary ciliary dyskinesia model generated from BMI1 transduced basal epithelial cells [0.03%]
BMI1转导基底上皮细胞产生的原发性纤毛运动障碍模型的特征分析
Melis T Dalbay,Eriomina Shahaj,Ileana Guerrini et al.
Melis T Dalbay et al.
Primary ciliary dyskinesia (PCD) is a rare genetic respiratory disorder, caused by a reduction in cilia number or dysmotility. Cilia dysmotility leads to breathing difficulties, concurrent infections and severe lung damage if not treated, w...
Phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons [0.03%]
磷脂酰肌醇聚磷酸盐影响秀丽隐杆线虫纤毛感觉神经元的细胞外囊泡脱落
Malek W Elsayyid,Alexis E Semmel,Krisha D Parekh et al.
Malek W Elsayyid et al.
Small secreted extracellular vesicles (EVs) mediate intercellular transport of bioactive macromolecules. How the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), which plays a critical role in many cellular processes, impac...
PGAM5 cleavage and oligomerization equilibrates mitochondrial dynamics under stress by regulating DRP1 function [0.03%]
PGAM5的切割和寡聚化通过调节DRP1的功能使压力下的线粒体动力学达到平衡
Sudeshna Nag,Kaitlin Szederkenyi,Christopher M Yip et al.
Sudeshna Nag et al.
Mitochondrial dynamics relies on the function of dynamin family GTPase proteins including mitofusin 1 (MFN1), mitofusin 2 (MFN2), and dynamin-related protein 1 (DRP1). The mitochondrial phosphatase phosphoglycerate mutase 5 (PGAM5) protein ...
CEP290-deficiency disrupts ciliary axonemal architecture in human iPSC-derived brain organoids [0.03%]
CEP290缺陷通过人多能干细胞脑类器官模型破坏纤毛轴突结构
Melanie Eschment,Olivier Mercey,Ellen M Aarts et al.
Melanie Eschment et al.
Primary cilia are ubiquitous sensory organelles mediating various signaling modalities essential for development and cell homeostasis. Their dysfunction leads to ciliopathies, human disorders often affecting the central nervous system. CEP2...
Danielle B Buglak,Brian J Galletta,Nasser M Rusan
Danielle B Buglak
A stable connection between the sperm head (nucleus) and tail (flagellum) is crucial for proper fertility. This linkage is mediated by centrioles, or their remnants, at a structure known as the head-tail coupling apparatus (HTCA). Although ...
Lamin B loss in nuclear blebs is rupture dependent while increased DNA damage is rupture independent [0.03%]
核泡中Lamin B的丧失与细胞核破裂相关，而DNA损伤的增加与细胞核破裂无关
Catherine G Chu,Nick Lang,Erin Walsh et al.
Catherine G Chu et al.
The nucleus must maintain shape and integrity to protect the function of the genome. Nuclear blebs are deformations identified by decreased DNA density that commonly lead to rupture. Lamin B levels often vary drastically between blebs. We t...