Maxim Averbukh,Tiffany Wang,Gilberto Garcia et al.
Maxim Averbukh et al.
The actin cytoskeleton is a highly dynamic and evolutionarily conserved multi-protein complex that regulates cellular architecture, mechanics and intracellular organization. Although actin dynamics and organization have been extensively stu...
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation [0.03%]
致癌性PIK3CA通过ERK波传播增强乳腺上皮细胞的集体迁移
Ali Dayoub,Artem I Fokin,Sergey Leonov et al.
Ali Dayoub et al.
Oncogenic mutations of the PIK3CA gene, which encodes the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K) enhance cell migration via ERK (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) activation. We analyzed the ...
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation [0.03%]
致癌基因PIK3CA通过ERK波传播增强乳腺上皮细胞的集体迁移
Ali Dayoub,Artem I Fokin,Sergey Leonov et al.
Ali Dayoub et al.
Oncogenic mutations of the PIK3CA gene, which encodes the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K) enhance cell migration via ERK (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) activation. We analyzed the ...
TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis [0.03%]
TRIM28通过组蛋白修饰和减数分裂卵母细胞中的DNA损伤修复调节G2 / M转换
Rui-Jie Ma,Meng-Meng Tang,Ping-Shuang Lu et al.
Rui-Jie Ma et al.
TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturat...
KATANIN is required for the formation of complete preprophase bands and subsequent division positioning in two asymmetric divisions of the maize stomatal complex [0.03%]
KATANIN在调控玉米气孔复合体的两次不对称分裂中的作用
Stephanie E Martinez,Carolyn G Rasmussen
Stephanie E Martinez
Microtubule dynamics underpin cell division, movement, and growth in eukaryotic organisms. KATANIN p60 is a microtubule-severing protein that promotes proper cell elongation and division. In plants, division positioning is initiated in late...
FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes [0.03%]
FGD1通过限制肌动蛋白肌球蛋白收缩性促进角化鳞状细胞中表皮基底上层连接的成熟
Diana I Hotea,Alexandra Jetté,Amy Beaudin et al.
Diana I Hotea et al.
The epidermis is a stratified epithelium in which keratinocytes differentiate as they move from basal to suprabasal layers, a process during which tissue integrity relies on the coordinated remodeling of intercellular junctions and the cyto...
Identification of feeding apparatus components in a heterotrophic marine flagellate [0.03%]
异养海洋鞭毛类摄食装置鉴定
Gillian Clifford,Samuel J P Taylor,Midori Ishii et al.
Gillian Clifford et al.
Diplonemids are highly abundant heterotrophic single-celled flagellates that are widespread in the world's ocean. They have a highly complex microtubule-based feeding apparatus (cytostome-cytopharynx complex) located adjacent to the deep fl...
Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12 [0.03%]
Tango1、Sec16和Sec12共同定义ER退出位点
Zhi Feng,Mercedes Martín,Marta Rojas et al.
Zhi Feng et al.
Endoplasmic reticulum (ER) exit sites (ERES) are dynamic ER subdomains where secretory cargos are concentrated and exported towards the Golgi apparatus. The conserved proteins Sec16 and Sec12 have long been implicated in ERES organization, ...
Phosphorylation of the AP2 µ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis [0.03%]
蛋白激酶p70S6通过磷酸化AP2的μ2亚基促进皮层内吞作用
Aleksandra Tempes,Agnieszka Brzozowska,Tomasz Węgierski et al.
Aleksandra Tempes et al.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles ...
Msh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids [0.03%]
Msh2缺失会影响食道类器官的细胞分化、增殖和代谢
Marjorie Rolland,Dominique Jean,Maude Hamilton et al.
Marjorie Rolland et al.
Due to a rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is ensured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that s...