Jack Darius Morgan
Jack Darius Morgan
Disabled scientists face tremendous barriers to entry into, and progression within, a scientific career, remaining immensely under-represented at every career stage. Disability inclusivity drives in science are increasingly prevalent, but f...
Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo [0.03%]
不相干前馈回路的动力学通过ERK依赖的方式形成果蝇早期胚胎中的图案
Emily K Ho,Harrison R Oatman,Sarah E McFann et al.
Emily K Ho et al.
Positional information in development often manifests as stripes of gene expression, but how stripes form remains incompletely understood. Here, we use optogenetics and live-cell biosensors to investigate the posterior brachyenteron (byn) s...
Frizzled2 receives WntA signaling during butterfly wing pattern formation [0.03%]
WntA信号通过Frizzled2在蝴蝶翅膀图案形成过程中的作用机制研究
Joseph J Hanly,Ling S Loh,Anyi Mazo-Vargas et al.
Joseph J Hanly et al.
Butterfly color patterns provide visible and biodiverse phenotypic readouts of the patterning processes. Although the secreted ligand WntA has been shown to instruct the color pattern formation in butterflies, its mode of reception remains ...
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion [0.03%]
notch驱动的基础细胞外排和Piezo1驱动的顶膜细胞外排控制了双相多纤毛细胞的外排现象
Rosa Ventrella,Sun K Kim,Jennifer Sheridan et al.
Rosa Ventrella et al.
Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is...
Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways [0.03%]
Erk和Akt信号通路对类胃器官图案化和形态发生的控制
Evan J Underhill,Jared E Toettcher
Evan J Underhill
Many developmental processes rely on the localized activation of receptor tyrosine kinases and their canonical downstream effectors Erk and Akt, yet the specific roles played by each of these signals is still poorly understood. Gastruloids,...
A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression [0.03%]
一个Rab39-Klp98A-Rab35的内吞循环途径对快速高尔基体依赖的细胞收缩缝形成是必需的
Hui Miao,Megan Millage,Katherine R Rollins et al.
Hui Miao et al.
Ingression of the plasma membrane is an essential part of the cell topology-distorting repertoire and a key element in animal cell cytokinesis. Many embryos have rapid cleavage stages in which they are furrowing powerhouses, quickly forming...
Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice [0.03%]
纹状膜平衡信号和Twist1丢失导致小鼠皮层折叠
Matt J Matrongolo,Khue-Tu Ho-Nguyen,Manav Jain et al.
Matt J Matrongolo et al.
Secondary lissencephaly evolved in mice due to effects on neurogenesis and the tangential distribution of neurons. Signaling pathways that help maintain lissencephaly are still poorly understood. We show that inactivating Twist1 in the prim...
Momoko Ikeuchi is an Associate Professor at Nara Institute of Science and Technology (NAIST) in the Division of Biological Science. Her lab studies plant regeneration, with a focus on the developmental mechanisms underlying callus formation...
DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16 [0.03%]
来自体细胞子宫组织的DNA损伤信号通过激活DAF-16使卵母细胞发生衰老
Gautam Chandra Sarkar,Umanshi Rautela,Anita Goyala et al.
Gautam Chandra Sarkar et al.
Germ line integrity is crucial for progeny fitness. Organisms deploy the DNA damage response (DDR) signaling to protect the germ line from genotoxic stress, facilitating the cell-cycle arrest of germ cells and DNA repair or their apoptosis....
Renee G C Maas,Floor W van den Dolder,Qianliang Yuan et al.
Renee G C Maas et al.
Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this...