aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for planarian head regeneration [0.03%]
Aristaless类同源框-3受伤口诱导并在头再生中促进低Wnt信号环境
Zaleena Akheralie,Tanner J Scidmore,Bret J Pearson
Zaleena Akheralie
The planarian Schmidtea mediterranea is a well-established model of adult regeneration, which is dependent on a large population of adult stem cells called neoblasts. Upon amputation, planarians undergo transcriptional wounding programs and...
An acytokinetic cell division creates PIP2-enriched membrane asymmetries leading to slit diaphragm assembly in Drosophila nephrocytes [0.03%]
无肌动蛋白细胞分裂通过产生PIP2富集的膜不对称性导致果蝇肾细胞中的裂隙隔板组装
Marta Carrasco-Rando,Joaquim Culi,Sonsoles Campuzano et al.
Marta Carrasco-Rando et al.
Vertebrate podocytes and Drosophila nephrocytes display slit diaphragms, specialised cell junctions that are essential for the execution of the basic excretory function of ultrafiltration. To elucidate the mechanisms of slit diaphragm assem...
Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling [0.03%]
Wnt9通过经典和非经典途径信号传导指导斑马鱼心脏管装配
Alessio Paolini,Dinara Sharipova,Tim Lange et al.
Alessio Paolini et al.
During zebrafish heart formation, cardiac progenitor cells converge at the embryonic midline where they form the cardiac cone. Subsequently, this structure transforms into a heart tube. Little is known about the molecular mechanisms that co...
Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme [0.03%]
味蕾乳头细胞分化需要ALK3-BMP信号在舌间充质中调节分泌蛋白的产生
Mohamed Ishan,Zhonghou Wang,Peng Zhao et al.
Mohamed Ishan et al.
Taste papillae are specialized organs, each of which comprises an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during early taste papilla development in mouse embryos, bone morpho...
Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis [0.03%]
小鼠卵母细胞的全局SUMO化维持卵母细胞特性并调节 folliculogenesis 结尾的染色质重塑和转录沉默
Shawn M Briley,Avery A Ahmed,Tessa E Steenwinkel et al.
Shawn M Briley et al.
Meiotically competent oocytes in mammals undergo cyclic development during folliculogenesis. Oocytes within ovarian follicles are transcriptionally active, producing and storing transcripts required for oocyte growth, somatic cell communica...
Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex [0.03%]
二氢叶酸还原酶活性控制发育中新皮层的神经发生转换事件
Sulov Saha,Thomas T Jungas,David Ohayon et al.
Sulov Saha et al.
One-carbon/folate (1C) metabolism supplies methyl groups required for DNA and histone methylation, and is involved in the maintenance of self-renewal in stem cells. Dihydrofolate reductase (DHFR), a key enzyme in 1C metabolism, is highly ex...
An inducible germ cell ablation chicken model for high-grade germline chimeras [0.03%]
一种可诱导的生殖细胞剔除鸡模型构建及高效个体嵌合体获得
Yi-Chen Chen,Daisuke Saito,Takayuki Suzuki et al.
Yi-Chen Chen et al.
Chicken embryos are a powerful and widely used animal model in developmental biology studies. Since the development of CRISPR technology, gene-edited chickens have been generated by transferring primordial germ cells (PGCs) into recipients ...
Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation [0.03%]
实时监测内源性Fgf8a梯度证实其在斑马鱼原肠运动期间的形态发生素作用
Rohit Krishnan Harish,Mansi Gupta,Daniela Zöller et al.
Rohit Krishnan Harish et al.
Morphogen gradients impart positional information to cells in a homogenous tissue field. Fgf8a, a highly conserved growth factor, has been proposed to act as a morphogen during zebrafish gastrulation. However, technical limitations have so ...
Ets-1 transcription factor regulates glial cell regeneration and function in planarians [0.03%]
ETS转录因子调节计划扁虫中胶细胞的再生和功能
Bidushi Chandra,Matthew G Voas,Erin L Davies et al.
Bidushi Chandra et al.
Glia play multifaceted roles in nervous systems in response to injury. Depending on the species, extent of injury and glial cell type in question, glia can help or hinder the regeneration of neurons. Studying glia in the context of successf...
Yuchuan Miao is a Postdoctoral Researcher at Harvard University, USA, where his research focuses on the development of in vitro stem cell models of somitogenesis. Yuchuan has been selected for Development's Pathway to Independence Programme...