Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion [0.03%]
补体转换酶依赖性调节膜连接和分泌配体以调节树突黏附
Nelson J Ramirez-Suarez,Helen M Belalcazar,Maisha Rahman et al.
Nelson J Ramirez-Suarez et al.
During neural development, cellular adhesion is crucial for interactions among and between neurons and surrounding tissues. This function is mediated by conserved cell adhesion molecules, which are tightly regulated to allow for coordinated...
Lydia Finley is an Associate Professor at the Memorial Sloan Kettering Cancer Center, New York, USA. Her research focuses on the metabolic programming of embryonic stem cells and how metabolism regulates and drives cell fate decisions. Lydi...
Loic Fort is a Postdoctoral Fellow in the lab of Ian Macara at Vanderbilt University. He is interested in understanding cell fate specification through the lens of mechanobiology, using 2D and 3D human stem cell systems. Loic is one of the ...
James Gahan is a Sir Henry Wellcome Postdoctoral Fellow supported by Rob Klose (University of Oxford, UK) and David Booth (University of California San Francisco, USA) interested in the evolutionary origins of animals and developmental gene...
rasa1-related arteriovenous malformation is driven by aberrant venous signalling [0.03%]
RASA1相关动静脉畸形由异常静脉信号驱动
Jasper Greysson-Wong,Rachael Rode,Jae-Ryeon Ryu et al.
Jasper Greysson-Wong et al.
Arteriovenous malformations (AVMs) develop where abnormal endothelial signalling allows direct connections between arteries and veins. Mutations in RASA1, a Ras GTPase activating protein, lead to AVMs in humans and, as we show, in zebrafish...
Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex [0.03%]
Polycomb通过控制Vestigial-Scalloped复合物来保障芽胚盘的特性化
Haley E Brown,Brandon P Weasner,Bonnie M Weasner et al.
Haley E Brown et al.
A fundamental goal of developmental biology is to understand how cell and tissue fates are specified. The imaginal discs of Drosophila are excellent model systems for addressing this paradigm as their fate can be redirected when discs regen...
The people behind the papers - Christopher Cooke and Naomi Moris [0.03%]
论文背后的人——Christopher Cooke和Naomi Moris
Primordial germ cells (PGCs) are the precursors of gametes, and a presumptive PGC-like cell (PGCLC) population was recently identified in mouse gastruloids. A new paper in Development investigates this population in detail and offers new in...
Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila [0.03%]
软骨素硫酸盐是果蝇卵泡上皮细胞的完整性及器官形态维持所必需的
Collin Knudsen,Woo Seuk Koh,Tomomi Izumikawa et al.
Collin Knudsen et al.
Heparan sulfate (HS) and chondroitin sulfate (CS) are evolutionarily conserved glycosaminoglycans that are found in most animal species, including the genetically tractable model organism Drosophila. In contrast to extensive in vivo studies...
Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis [0.03%]
单细胞转录组分析识别出果蝇羽化初期释放的新型血细胞群落
Alexander Hirschhäuser,Darius Molitor,Gabriela Salinas et al.
Alexander Hirschhäuser et al.
Drosophila blood cells called hemocytes form an efficient barrier against infections and tissue damage. During metamorphosis, hemocytes undergo tremendous changes in their shape and behavior, preparing them for tissue clearance. Yet, the di...