Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice [0.03%]
脊髓尾端Fgfr1缺失在小鼠中产生局部脊髓分型错误及终末性类似脊髓栓系的囊状畸形表型
Eirini Maniou,Faduma Farah,Abigail R Marshall et al.
Eirini Maniou et al.
Closed spinal dysraphisms are poorly understood malformations classified as neural tube (NT) defects. Several, including terminal myelocystocele, affect the distal spine. We have previously identified a NT closure-initiating point, Closure ...
The people behind the papers - Matt Matrongolo and Max Tischfield [0.03%]
论文背后的科学家——马特·马特罗诺戈和马克斯·蒂施菲尔德
Cortical folding is a highly regulated process involving amplification of neuroprogenitor cells, increased neurogenesis and migration of neurons along the tangential axis. A new paper in Development investigates the signalling processes beh...
An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish [0.03%]
Eda/NF-κB信号活性行进波控制斑马鱼皮肤附属物的定时和六角形模式
Maya N Evanitsky,Stefano Di Talia
Maya N Evanitsky
Periodic patterns drive the formation of a variety of tissues, including skin appendages such as feathers and scales. Skin appendages serve important and diverse functions across vertebrates, yet the mechanisms that regulate their patternin...
Jared Rutter's group studies the mechanisms by which cells sense their metabolic environment and integrate these signals to influence cell behaviors. Jared completed his PhD at the University of Texas Southwestern Medical Center, USA, where...
Joshua Gendron is Associate Professor of Molecular, Cellular and Developmental Biology at Yale University, USA. His research focuses on understanding how protein degradation systems regulate timing mechanisms and environment sensing in plan...
PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate [0.03%]
PUF-8是线虫中PUM1和PUM2的同源RNA结合蛋白，能够维持细胞死亡命运的稳健性
Jimei Xu,Yanwen Jiang,Ryan Sherrard et al.
Jimei Xu et al.
During C. elegans development, 1090 somatic cells are generated, of which 959 survive and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans ortholog of the mammalian RNA-binding proteins PUM1 and PUM2, is require...
Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance [0.03%]
Slit/罗bo和Wnt/Frizzled信号通路在轴突引导中的联系分子：电缆1蛋白质
Nikole R Zuñiga,Alexandre Dumoulin,Giuseppe Vaccaro et al.
Nikole R Zuñiga et al.
During neural circuit formation, axons navigate from one intermediate target to the next, until they reach their final target. At intermediate targets, axons switch from being attracted to being repelled by changing the guidance receptors o...
Gastric epithelial stem cells in development, homeostasis and regeneration [0.03%]
胃上皮干细胞在发育、稳态和再生中的作用
Fidelia B Alvina,Tanysha Chi-Ying Chen,Hui Yi Grace Lim et al.
Fidelia B Alvina et al.
The stem/progenitor cell pool is indispensable for the development, homeostasis and regeneration of the gastric epithelium, owing to its defining ability to self-renew whilst supplying the various functional epithelial lineages needed to di...
Priti Agarwal is a Postdoctoral Researcher in Ronen Zaidel-Bar's lab (Tel Aviv University, Israel) interested in deciphering the mechanical regulation of organogenesis. Priti is one of the cohort of Development's first Pathway to Independen...
N6-adenosine methylation of mRNA integrates multilevel auxin response and ground tissue development in Arabidopsis [0.03%]
拟南芥mRNA N6-腺苷甲基化整合生长素响应和后层组织发育
Elena A Zemlyanskaya,Viacheslav Zemlianski,Aleš Pěnčík et al.
Elena A Zemlyanskaya et al.
N6-methyl adenosine (m6A) is a widespread internal mRNA modification impacting the expression of numerous genes. Here, we characterize auxin-related defects among the pleiotropic phenotypes of hypomorphic Arabidopsis thaliana mutants with i...