Aimee Jaramillo-Lambert is currently an Assistant Professor at the University of Delaware. Aimee was awarded the Society for Developmental Biology 2023 Elizabeth D. Hay New Investigator Award in recognition of her outstanding research in de...
Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis [0.03%]
Pramel1通过在精子发生过程中抑制视黄酸信号调节小鼠的精原细胞发育
Mingyao Yang,Wenzhi Ma,Jon Oatley et al.
Mingyao Yang et al.
Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. The underlying cellular and molecular mechanisms in thi...
Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms [0.03%]
类似chemokine的Orion蛋白参与了不同发育性神经重塑范式中胶质细胞向吞噬细胞转化的过程
Clarisse Perron,Pascal Carme,Arnau Llobet Rosell et al.
Clarisse Perron et al.
During animal development, neurons often form exuberant or inappropriate axons and dendrites at early stages, followed by the refinement of neuronal circuits at late stages. Neural circuit refinement leads to the production of neuronal debr...
The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs [0.03%]
CCR4-NOT复合体抑制母源mRNA提前进行翻译激活
Shou Soeda,Masaaki Oyama,Hiroko Kozuka-Hata et al.
Shou Soeda et al.
Control of mRNA poly(A) tails is essential for regulation of mRNA metabolism, specifically translation efficiency and mRNA stability. Gene expression in maturing oocytes relies largely on post-transcriptional regulation, as genes are transc...
UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting [0.03%]
UNC-116和UNC-16通过NEKL-3激酶促进轴突导向功能
Cody J Drozd,Christopher C Quinn
Cody J Drozd
KIF5C is a kinesin-1 heavy chain that has been associated with neurodevelopmental disorders. Although the roles of kinesin-1 in axon transport are well known, little is known about how it regulates axon targeting. We report that UNC-116/KIF...
The Tbx20-TLE interaction is essential for the maintenance of the second heart field [0.03%]
Tbx20-TLE互作对于第二心脏场的维持是必不可少的
Whitney Edwards,Olivia K Bussey,Frank L Conlon
Whitney Edwards
T-box transcription factor 20 (Tbx20) plays a multifaceted role in cardiac morphogenesis and controls a broad gene regulatory network. However, the mechanism by which Tbx20 activates and represses target genes in a tissue-specific and tempo...
Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans [0.03%]
肌动蛋白和CDC-42通过C. elegans中的狭窄空间促进细胞核迁移
Jamie Ho,Leslie A Guerrero,Diana E Libuda et al.
Jamie Ho et al.
Successful nuclear migration through constricted spaces between cells or in the extracellular matrix relies on the ability of the nucleus to deform. Little is known about how this takes place in vivo. We have studied confined nuclear migrat...
Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature [0.03%]
小鼠脑血管周纤维母细胞的脑膜起源及发育动力学规律研究
Hannah E Jones,Vanessa Coelho-Santos,Stephanie K Bonney et al.
Hannah E Jones et al.
Perivascular fibroblasts (PVFs) are a fibroblast-like cell type that reside on large-diameter blood vessels in the adult meninges and central nervous system (CNS). PVFs contribute to fibrosis following injury but their homeostatic functions...
The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border [0.03%]
Foxi3转录因子对于神经板边缘斑板块系命运限制的必要性
Ankita Thawani,Helen R Maunsell,Hongyuan Zhang et al.
Ankita Thawani et al.
The Foxi3 transcription factor, expressed in the neural plate border at the end of gastrulation, is necessary for the formation of posterior placodes and is thus important for ectodermal patterning. We have created two knock-in mouse lines ...
scTOP: physics-inspired order parameters for cellular identification and visualization [0.03%]
基于物理的细胞识别与可视化序参量方法(scTOP)
Maria Yampolskaya,Michael J Herriges,Laertis Ikonomou et al.
Maria Yampolskaya et al.
Advances in single-cell RNA sequencing provide an unprecedented window into cellular identity. The abundance of data requires new theoretical and computational frameworks to analyze the dynamics of differentiation and integrate knowledge fr...