Clotilde Cadart undertook her PhD thesis with Matthieu Piel at the Curie Institute in Paris, before moving on to a postdoc with Rebecca Heald at the University of California Berkeley. Her interests lie in understanding the links between cel...
KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila [0.03%]
KDM5介导的线粒体生物学所需基因的激活在果蝇中是必不可少的
Michael F Rogers,Owen J Marshall,Julie Secombe
Michael F Rogers
Histone-modifying proteins play important roles in the precise regulation of the transcriptional programs that coordinate development. KDM5 family proteins interact with chromatin through demethylation of H3K4me3 as well as demethylase-inde...
Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis [0.03%]
ACTL7B缺乏导致LC8类型动力蛋白轻链错位并干扰小鼠精子发生
Gina E Merges,Lena Arévalo,Andjela Kovacevic et al.
Gina E Merges et al.
Actin-related proteins (Arps) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp, and is highly conserved in rodents and primates. ACTL7B is specifically exp...
Matthew R Steinhart,Wouter H van der Valk,Daniel Osorio et al.
Matthew R Steinhart et al.
Inner ear development requires the coordination of cell types from distinct epithelial, mesenchymal and neuronal lineages. Although we have learned much from animal models, many details about human inner ear development remain elusive. We r...
A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster [0.03%]
高糖饮食而非肥胖会减少果蝇的雌性生育力
Rodrigo Dutra Nunes,Daniela Drummond-Barbosa
Rodrigo Dutra Nunes
Obesity is linked to reduced fertility in various species, from Drosophila to humans. Considering that obesity is often induced by changes in diet or eating behavior, it remains unclear whether obesity, diet, or both reduce fertility. Here,...
Luisa Cochella,Zayna Chaker
Luisa Cochella
The Jacques Monod Conference on 'Growth and regeneration during development and aging' was organized by Claude Desplan and Allison Bardin in May 2023. The conference took place in Roscoff, France, where participants shared recent conceptual...
Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro [0.03%]
人多能干细胞来源的耳囊类器官在体外再现听囊发育
Daniela Doda,Sara Alonso Jimenez,Hubert Rehrauer et al.
Daniela Doda et al.
Our molecular understanding of the early stages of human inner ear development has been limited by the difficulty in accessing fetal samples at early gestational stages. As an alternative, previous studies have shown that inner ear morphoge...
The people behind the papers - Rohit Krishnan Harish and Michael Brand [0.03%]
论文背后的人——罗希特·克里希南·哈里斯和迈克尔·布兰德
Rohit Krishnan Harish,Michael Brand
Rohit Krishnan Harish
The growth factor Fgf8a has been suggested to act as a morphogen during zebrafish gastrulation, spreading from a localized source to form a concentration gradient and impart positional information to cells along a tissue field. In a new pap...
Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development [0.03%]
内皮细胞SMAD6通过调节粘附斑和肝脏血管发育平衡ALK1功能
Molly R Kulikauskas,Morgan Oatley,Tianji Yu et al.
Molly R Kulikauskas et al.
BMP signaling is crucial to blood vessel formation and function, but how pathway components regulate vascular development is not well-understood. Here, we find that inhibitory SMAD6 functions in endothelial cells to negatively regulate ALK1...
The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation [0.03%]
EBF1转录因子非自主性调节心脏生长和分化
Eugene E Kim,Akshay Shekhar,Jayalakshmi Ramachandran et al.
Eugene E Kim et al.
Reciprocal interactions between non-myocytes and cardiomyocytes regulate cardiac growth and differentiation. Here, we report that the transcription factor Ebf1 is highly expressed in non-myocytes and potently regulates heart development. Eb...