Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells to primitive-ectoderm-like cells [0.03%]
L-脯氨酸诱导信号通路的互作可驱动小鼠胚胎干细胞向原始外胚层样细胞分化
Hannah J Glover,Holly Holliday,Rachel A Shparberg et al.
Hannah J Glover et al.
The amino acid L-proline exhibits growth factor-like properties during development - from improving blastocyst development to driving neurogenesis in vitro. Addition of 400 μM L-proline to self-renewal medium drives naïve mouse embryonic ...
Gibberellin and miRNA156-targeted SlSBP genes synergistically regulate tomato floral meristem determinacy and ovary patterning [0.03%]
赤霉素和miRNA156共同调控番茄花分生组织确定性和子房模式建成中的SlSBP基因的协同作用
Leticia F Ferigolo,Mateus H Vicente,Joao P O Correa et al.
Leticia F Ferigolo et al.
Many developmental processes associated with fruit development occur at the floral meristem (FM). Age-regulated microRNA156 (miR156) and gibberellins (GAs) interact to control flowering time, but their interplay in subsequent stages of repr...
Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation [0.03%]
基质netrin 1协调肾动脉发生和肌成纤维细胞分化
Peter M Luo,Xiaowu Gu,Christopher Chaney et al.
Peter M Luo et al.
The kidney vasculature has a complex architecture that is essential for renal function. The molecular mechanisms that direct development of kidney blood vessels are poorly characterized. We identified a regionally restricted, stroma-derived...
A model of replicating coupled oscillators generates naturally occurring cell networks [0.03%]
一种相互耦合的振荡器复制模型产生自然发生的细胞网络
Matthew Smart,Stanislav Y Shvartsman,Hayden Nunley
Matthew Smart
When a founder cell and its progeny divide with incomplete cytokinesis, a network forms in which each intercellular bridge corresponds to a past mitotic event. Such networks are required for gamete production in many animals, and different ...
A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish [0.03%]
结合Pax3/7、Sox10和Mitf生成斑马鱼和日本鲤鱼多式样的色素细胞类型基因调控网络
Motohiro Miyadai,Hiroyuki Takada,Akiko Shiraishi et al.
Motohiro Miyadai et al.
Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network for melanocytes (their o...
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans [0.03%]
SIN-3通过不同的复合体调节秀丽隐杆线虫生殖系的转录程序
Valerie J Robert,Matthieu Caron,Loic Gely et al.
Valerie J Robert et al.
The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intel...
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans [0.03%]
SIN-3通过不同的复合体调节Caenorhabditis elegans的生殖系转录程序
Valerie J Robert,Matthieu Caron,Loic Gely et al.
Valerie J Robert et al.
The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intel...
Netrin 1 directs vascular patterning and maturity in the developing kidney [0.03%]
神经细胞粘附分子Netrin 1在肾脏发育中的血管模式和成熟度形成中起导向作用
Samuel E Honeycutt,Pierre-Emmanuel Y N&#x;Guetta,Deanna M Hardesty et al.
Samuel E Honeycutt et al.
The intricate vascular system of the kidneys supports body fluid and organ homeostasis. However, little is known about how vascular architecture is established during kidney development. More specifically, how signals from the kidney influe...
Priti Agarwal,Clotilde Cadart,Loic Fort et al.
Priti Agarwal et al.
In 2022, Development launched its Pathway to Independence (PI) Programme, aimed at supporting postdocs as they transition to their first independent position. We selected eight talented researchers as the first cohort of PI Fellows. In this...
Kuo-Chang Tseng,J Gage Crump
Kuo-Chang Tseng
The evolution of a unique craniofacial complex in vertebrates made possible new ways of breathing, eating, communicating and sensing the environment. The head and face develop through interactions of all three germ layers, the endoderm, ect...