Leveraging dominant-negative histone H3 K-to-M mutations to study chromatin during differentiation and development [0.03%]
利用组蛋白H3 K到M突变体研究表观遗传在分化和发育中的作用
Ksenia Serdyukova,Alison R Swearingen,Mariel Coradin et al.
Ksenia Serdyukova et al.
Histone modifications are associated with regulation of gene expression that controls a vast array of biological processes. Often, these associations are drawn by correlating the genomic location of a particular histone modification with ge...
Abscisic acid biosynthesis is necessary for full auxin effects on hypocotyl elongation [0.03%]
赤霉素的合成是生长素影响下胚轴伸长的必要条件
Ryan J Emenecker,Joseph Cammarata,Irene Yuan et al.
Ryan J Emenecker et al.
In concert with other phytohormones, auxin regulates plant growth and development. However, how auxin and other phytohormones coordinately regulate distinct processes is not fully understood. In this work, we uncover an auxin-abscisic acid ...
HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development [0.03%]
己糖激酶1和葡萄糖-6-磷酸为植物生长发育提供能量
Morgan Vanderwall,Joshua M Gendron
Morgan Vanderwall
As photoautotrophic organisms, plants produce an incredible spectrum of pigments, anti-herbivory compounds, structural materials and energic intermediates. These biosynthetic routes help plants grow, reproduce and mitigate stress. HEXOKINAS...
A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut [0.03%]
支配羊膜类动物hindgut延长的内胚层运动的化学力学模型
Panagiotis Oikonomou,Helena C Cirne,Nandan L Nerurkar
Panagiotis Oikonomou
Although mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics remains understudied during vertebrate morphogenesis. Here, we developed a two-dim...
An interactive resource of molecular signalling in the developing human haematopoietic stem cell niche [0.03%]
人类造血干细胞生态位分子信号互动资源库
Edie I Crosse,Anahi Binagui-Casas,Sabrina Gordon-Keylock et al.
Edie I Crosse et al.
The emergence of definitive human haematopoietic stem cells (HSCs) from Carnegie Stage (CS) 14 to CS17 in the aorta-gonad-mesonephros (AGM) region is a tightly regulated process. Previously, we conducted spatial transcriptomic analysis of t...
Elizabeth R Westbrook,Hugh Z Ford,Vlatka Antolović et al.
Elizabeth R Westbrook et al.
The distribution of mRNA in tissue is determined by the balance between transcription and decay. Understanding the control of RNA decay during development has been somewhat neglected compared with transcriptional control. Here, we explore t...
Elizabeth R Westbrook,Hugh Z Ford,Vlatka Antolović et al.
Elizabeth R Westbrook et al.
The distribution of mRNA in tissue is determined by the balance between transcription and decay. Understanding the control of RNA decay during development has been somewhat neglected compared with transcriptional control. Here, we explore t...
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism [0.03%]
胎盘介导的母子交流对后代发育和代谢的影响
Avery C Kramer,Thomas Jansson,Tracy L Bale et al.
Avery C Kramer et al.
Compelling epidemiological and animal experimental data demonstrate that cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine environment. Here, we review evidence suggesting that altered placental function m...
Accurate staging of chick embryonic tissues via deep learning of salient features [0.03%]
基于显著特征的深度学习精确划分鸡胚胎组织阶段
Ian Groves,Jacob Holmshaw,David Furley et al.
Ian Groves et al.
Recent work shows that the developmental potential of progenitor cells in the HH10 chick brain changes rapidly, accompanied by subtle changes in morphology. This demands increased temporal resolution for studies of the brain at this stage, ...
Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons [0.03%]
钙信号调节发育神经元树突中AMPK活性和线粒体稳态
Akane Hatsuda,Junko Kurisu,Kazuto Fujishima et al.
Akane Hatsuda et al.
Dendritic outgrowth in immature neurons is enhanced by neuronal activity and is considered one of the mechanisms of neural circuit optimization. It is known that calcium signals affect transcriptional regulation and cytoskeletal remodeling ...