Meritxell (Meri) Huch is a Director and Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, where her group uses 3D organoid models to study the maintenance and repair of adult tissues, as well as the m...
Pathway to Independence: a forecast for the future of developmental biology [0.03%]
走向独立：发展生物学未来的预测报告
Chee Kiang Ewe,Max S Farnworth,Anzy Miller et al.
Chee Kiang Ewe et al.
In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third cohort of eight talented PI fellows. In this articl...
Speaking science in a fractured world: making truth land when facts alone cannot [0.03%]
破碎世界中的科学话语权：当事实不再奏效时，我们如何寻求真相
Rebecca M Calisi-Rodríguez,Kevin Alicea-Torres,Jamy C Peng et al.
Rebecca M Calisi-Rodríguez et al.
Scientific misinformation is a defining challenge of our time. As public trust in science declines and falsehoods spread faster than facts, the scientific community must rethink its role in public discourse. This Perspective draws on a scen...
Ashley Moffett,Geraldine M Jowett
Ashley Moffett
Professor Azim Surani is the Director of Epigenomics and Germline Imprinting at the Gurdon Institute in Cambridge, UK. He is this year's recipient of both the prestigious Kyoto Prize and the Paul Ehrlich and Ludwig Darmstaedter prize, recog...
Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids [0.03%]
细调机械约束可揭示小鼠胚状体中独立的图案形成和基因表达程序
Judith Pineau,Jerome Wong-Ng,Alexandre Mayran et al.
Judith Pineau et al.
The interplay between mechanical forces and genetic programs is fundamental to embryonic development, yet how these factors influence morphogenesis and cell fate decisions remains unclear. Here, we fine-tune the mechanical environment of mu...
Circadian clock genes perform dual roles as systemic oscillators and context-dependent regulators [0.03%]
生物钟基因兼具系统振荡器和环境依赖性调节因子的双重作用
Nozomu Takahashi,Motomu Endo
Nozomu Takahashi
The plant circadian clock aligns developmental processes with environmental cycles, a function traditionally attributed to a unified, systemic oscillator. However, this view is challenged by observations that mutations in specific clock gen...
The people behind the papers - Judith Pineau, Jerome Wong-Ng and Thomas Gregor [0.03%]
论文背后的人——朱迪思·皮纳尔、杰罗姆·黄和托马斯·格雷戈尔
Mechanical constraint has a strong influence on development, but its exact impact on transcriptional patterning remains unclear. In a new study, Pineau et al. use gastruloids - embryonic stem cell-derived aggregates that display anteroposte...
Embryonic enhancers help transmit positional information to the initiator cores that control Drosophila Abd-B regulatory domains [0.03%]
早期增强子帮助传递位置信息至控制果蝇Abd-B调控区域的发起核心
Olga Kyrchanova,Ksenia Kudryashova,Airat Ibragimov et al.
Olga Kyrchanova et al.
Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer ac...
Ectodysplasin (Eda), a member of the tumour necrosis factor (TNF) superfamily of proteins, regulates proper dental development in vertebrates. In their study, Tyler Square and colleagues show that Eda drives latent tooth-forming competency ...
Differential regulation of coronal and lambdoid suture patency by PTHLH and HHIP activity in mice [0.03%]
PTHLH和HHIP在小鼠冠状缝和朗伯氏缝调节中的不同作用
Madrikha D Saturne,Susan M Motch Perrine,Qingyang Li et al.
Madrikha D Saturne et al.
Craniofacial development depends on the formation of fibrous joints, or sutures, between skull bones. Premature fusion of sutures, or craniosynostosis, is a common human pathology. Ectopic Hedgehog (HH) signaling is one cause of craniosynos...