Competition for H2A.Z underlies the developmental impacts of repetitive element de-repression [0.03%]
H2A.Z在重复元件去抑制的发育影响中的竞争作用机制研究
Fanju W Meng,Kristin E Murphy,Claire E Makowski et al.
Fanju W Meng et al.
The histone variant H2A.Z is central to early embryonic development, determining transcriptional competency through chromatin regulation of gene promoters and enhancers. In addition to genic loci, we find that H2A.Z resides at a subset of e...
The people behind the papers - Akane Hatsuda and Mineko Kengaku [0.03%]
论文背后的科研人—— hatsuda akane 和 kengaku mineko教授
Calcium signals evoked by neuronal activity play an important role in dendritic development and establishment of neuronal circuit connectivity. A new study demonstrates a link between activity-dependent dendritic development and AMP-activat...
Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly [0.03%]
先驱的 statoacoustic 神经元在otic神经节组装期间指导神经母细胞行为
Aitor Bañón,Berta Alsina
Aitor Bañón
Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation. The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to connect appropriately with hair cells of the inner ear. ...
Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda [0.03%]
Zelda这一泛在因子通过多级调节机制调控even-skipped条带表达
Timothy R Bishop,Pinar Onal,Zhe Xu et al.
Timothy R Bishop et al.
The zinc-finger protein Zelda (Zld) is a key activator of zygotic transcription in early Drosophila embryos. Here, we study Zld-dependent regulation of the seven-striped pattern of the pair-rule gene even-skipped (eve). Individual stripes a...
Correction: Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling [0.03%]
Correction: 基于经典和非经典信号通路的Wnt9调控斑马鱼心脏管形成
Alessio Paolini,Dinara Sharipova,Tim Lange et al.
Alessio Paolini et al.
Published Erratum
Development (Cambridge, England). 2023 Nov 1;150(21):dev202439. DOI:10.1242/dev.202439 2023
The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations [0.03%]
染色质源库假说：一种基于染色质介导的调控机制
Patrick J Murphy,Frédéric Berger
Patrick J Murphy
We propose that several chromatin-mediated regulatory processes are dominated by source-sink relationships in which factors operate as 'sources' to produce or provide a resource and compete with each other to occupy separate 'sinks'. In thi...
The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations [0.03%]
染色质源库假说：染色质介导调控的共通模式
Patrick J Murphy,Frédéric Berger
Patrick J Murphy
We propose that several chromatin-mediated regulatory processes are dominated by source-sink relationships in which factors operate as 'sources' to produce or provide a resource and compete with each other to occupy separate 'sinks'. In thi...
In preprints: shrinking boundary cells reveal fluid flux in organogenesis [0.03%]
shrink边界细胞揭示了器官发生过程中的流体通量
Karthikbabu Kannivadi Ramakanth,Yuchen Long
Karthikbabu Kannivadi Ramakanth
Elizabeth R Westbrook,Tchern Lenn,Jonathan R Chubb et al.
Elizabeth R Westbrook et al.
Development can proceed in 'fits and starts', with rapid transitions between cell states involving concerted transcriptome-wide changes in gene expression. However, it is not clear how these transitions are regulated in complex cell populat...
NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation [0.03%]
NOTCH3信号控制人绒毛膜干细胞的扩增和分化
Bianca Dietrich,Victoria Kunihs,Andreas I Lackner et al.
Bianca Dietrich et al.
Failures in growth and differentiation of the early human placenta are associated with severe pregnancy disorders such as pre-eclampsia and fetal growth restriction. However, regulatory mechanisms controlling development of placental epithe...