Andrew Keniry,Marnie E Blewitt
Andrew Keniry
In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin state on the inactive X (Xi) chromosome. There is a...
Transitions in development - an interview with Amy Shyer and Alan Rodrigues [0.03%]
发育中的转换——与Amy Shyer和Alan Rodrigues的访谈
Amy Shyer and Alan Rodrigues co-lead the Laboratory of Morphogenesis at Rockefeller University. Having first met as graduate students in Cliff Tabin's lab at Harvard University, they then moved to the Bay Area (California), where Amy carrie...
Otto J M Mäkelä,Marja L Mikkola
Otto J M Mäkelä
Tissue interactions are essential for guiding organ development and regeneration. Hair follicle formation relies on inductive signalling between two tissues, the embryonic surface epithelium and the adjacent mesenchyme. Although previous re...
Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale [0.03%]
早期哺乳动物器官生成的追踪研究——整体层面上分化轨迹的预测和验证
Ivan Imaz-Rosshandler,Christina Rode,Carolina Guibentif et al.
Ivan Imaz-Rosshandler et al.
Early organogenesis represents a key step in animal development, during which pluripotent cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell transcriptomes from mouse embryos between E8.5 and E9.5 in 6-h inter...
GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate [0.03%]
C. elegans Hedgehog/ patched样配体受体调节发育速率
Sinclair W Emans,Armen Yerevanian,Fasih M Ahsan et al.
Sinclair W Emans et al.
Both hedgehog (Hh) and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved signaling pathways that regulate development and metabolism. In C. elegans, loss of the essential TORC2 component RICTOR (rict-1) causes dela...
Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease [0.03%]
中心体生物发生异常扰乱肾小球和集合管干细胞的生长和命运导致进行性肾纤维性囊性病
Tao Cheng,Chidera Agwu,Kyuhwan Shim et al.
Tao Cheng et al.
Mutations that disrupt centrosome biogenesis or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet how centrosome dysfunction results in the kidney disease phenotypes remains unknown. Here, we examined t...
Dysregulation of the endoplasmic reticulum blocks recruitment of centrosome-associated proteins resulting in mitotic failure [0.03%]
内质网失调通过干扰中心体相关蛋白的募集导致有丝分裂失败
Katherine R Rollins,J Todd Blankenship
Katherine R Rollins
The endoplasmic reticulum (ER) undergoes a remarkable transition in morphology during cell division to aid in the proper portioning of the ER. However, whether changes in ER behaviors modulate mitotic events is less clear. Like many animal ...
Yuka W Iwasaki,Haruhiko Koseki,Shinsuke Ito
Yuka W Iwasaki
Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas [0.03%]
肝素结合表皮生长因子和成纤维细胞生长因子2可挽救小胶质细胞和巨噬细胞耗竭鸡视网膜中Müller胶质细胞衍生的祖细胞形成
Heithem M El-Hodiri,James R Bentley,Alana G Reske et al.
Heithem M El-Hodiri et al.
Recent studies have demonstrated the impact of pro-inflammatory signaling and reactive microglia/macrophages on the formation of Müller glial-derived progenitor cells (MGPCs) in the retina. In chick retina, ablation of microglia/macrophage...
Two modes of gene regulation by TFL1 mediate its dual function in flowering time and shoot determinacy of Arabidopsis [0.03%]
拟南芥中TFL1基因调节的两种模式介导其在开花时间和枝条决定中的双重功能
Martina Cerise,Vítor da Silveira Falavigna,Gabriel Rodríguez-Maroto et al.
Martina Cerise et al.
Plant organ primordia develop successively at the shoot apical meristem (SAM). In Arabidopsis, primordia formed early in development differentiate into vegetative leaves, whereas those formed later generate inflorescence branches and flower...