Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts [0.03%]
硬骨鱼类通过Wnt和BMP信号的相反响应调节牙齿再生
Tyler A Square,Emma J Mackey,Shivani Sundaram et al.
Tyler A Square et al.
Most vertebrate species undergo tooth replacement throughout adult life. This process is marked by the shedding of existing teeth and the regeneration of tooth organs. However, little is known about the genetic circuitry regulating tooth re...
Local auxin biosynthesis promotes shoot patterning and stem cell differentiation in Arabidopsis shoot apex [0.03%]
拟南芥地上分生组织中局部生长素生物合成促进 shoots模式和干细胞分化
Shalini Yadav,Harish Kumar,Monika Mahajan et al.
Shalini Yadav et al.
The shoot apical meristem (SAM) of higher plants comprises distinct functional zones. The central zone (CZ) is located at the meristem summit and harbors pluripotent stem cells. Stem cells undergo cell division within the CZ and give rise t...
The H2Bub1-deposition complex is required for human and mouse cardiogenesis [0.03%]
H2Bub1沉积复合物是人类和小鼠心脏发育所必需的
Syndi Barish,Kathryn Berg,Jeffrey Drozd et al.
Syndi Barish et al.
De novo variants affecting monoubiquitylation of histone H2B (H2Bub1) are enriched in human congenital heart disease. H2Bub1 is required in stem cell differentiation, cilia function, post-natal cardiomyocyte maturation and transcriptional e...
Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function [0.03%]
Furin的RNA调控子介导的翻译控制对于左右模式化、心脏形态发生和心脏瓣膜功能很重要
Agnieszka Nagorska,Andreas Zaucker,Finnlay Lambert et al.
Agnieszka Nagorska et al.
Heart development is a complex process that requires asymmetric positioning of the heart, cardiac growth and valve morphogenesis. The mechanisms controlling heart morphogenesis and valve formation are not fully understood. The pro-convertas...
On the origins of developmental robustness: modeling buffering mechanisms against cell-level noise [0.03%]
论发育稳健性的起源：对抗细胞水平噪声的缓冲机制建模
Hugo Cano-Fernández,Tazzio Tissot,Miguel Brun-Usan et al.
Hugo Cano-Fernández et al.
During development, cells are subject to stochastic fluctuations in their positions (i.e. cell-level noise) that can potentially lead to morphological noise (i.e. stochastic differences between morphologies that are expected to be equal, e....
An EMC-Hpo-Yki axis maintains intestinal homeostasis under physiological and pathological conditions [0.03%]
EMC-Hpo-Yki轴在生理和病理条件下维持肠稳态
Lin Shi,Hubing Ma,Jinjun Wang et al.
Lin Shi et al.
Balanced control of stem cell proliferation and differentiation underlines tissue homeostasis. Disruption of tissue homeostasis often results in many diseases. However, how endogenous factors influence the proliferation and differentiation ...
Mycah T Sewell,Emilie Legué,Karel F Liem Jr
Mycah T Sewell
Cilia are microtubule (MT)-based organelles present on the surface of nearly all vertebrate cells. MTs are polymers of α- and β-tubulins that are each encoded by multiple, individual isotype genes. Tubulin isotype composition is thought t...
Azusa Inoue is a Team Leader at RIKEN Center for Integrative Medical Sciences (IMS) in Japan. His lab studies oocyte-mediated epigenetic inheritance by understanding the mechanisms of epigenome establishment and reprogramming. Last year, Az...
Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes [0.03%]
Sall1和Sall4通过调节CDK和cyclin基因促进心肌细胞增殖的机制研究
Wataru Katano,Shunta Mori,Shun Sasaki et al.
Wataru Katano et al.
Sall1 and Sall4 (Sall1/4), zinc-finger transcription factors, are expressed in the progenitors of the second heart field (SHF) and in cardiomyocytes during the early stages of mouse development. To understand the function of Sall1/4 in hear...
Marysia Placzek is Professor of Developmental Neurobiology at the University of Sheffield, UK, where her lab studies the development of the hypothalamus. In 2023, she was awarded the British Society for Developmental Biology's (BSDB) Waddin...