Stanley M Kanai,David E Clouthier
Stanley M Kanai
Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their receptors in the regulation of blood pressure in normal and disease states has been extensively studied. However, endothelin signaling also plays c...
Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis [0.03%]
Nr5a1缺失通过诱导支持细胞anoikis死亡改变小鼠支持细胞性别分化后的身份属性
Sirine Souali-Crespo,Diana Condrea,Nadège Vernet et al.
Sirine Souali-Crespo et al.
To investigate the role of the nuclear receptor NR5A1 in the testis after sex determination, we analyzed mice lacking NR5A1 in Sertoli cells (SCs) from embryonic day (E) 13.5 onwards. Ablation of Nr5a1 impaired the expression of genes chara...
Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis [0.03%]
Nr5a1在性别决定后从支持细胞中的丢失改变了细胞身份并导致脱离性死亡
Sirine Souali-Crespo,Diana Condrea,Nadège Vernet et al.
Sirine Souali-Crespo et al.
To investigate the role of the nuclear receptor NR5A1 in the testis after sex determination, we analyzed mice lacking NR5A1 in Sertoli cells (SCs) from embryonic day (E) 13.5 onwards. Ablation of Nr5a1 impaired the expression of genes chara...
In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated co-expression of Atoh1 and Tbx2 [0.03%]
Atoh1和Tbx2时空调控的协同表达在受损耳蜗内毛细胞原位再生中的作用
Xiang Li,Minhui Ren,Yunpeng Gu et al.
Xiang Li et al.
Cochlear inner hair cells (IHCs) are primary sound receptors, and are therefore a target for developing treatments for hearing impairment. IHC regeneration in vivo has been widely attempted, although not yet in the IHC-damaged cochlea. More...
PAR-4/LKB1 prevents intestinal hyperplasia by restricting endoderm specification in Caenorhabditis elegans embryos [0.03%]
PAR-4/LKB1通过限制芽球秀丽隐杆线虫胚胎的内胚层分化来预防肠上皮增生
Flora Demouchy,Ophélie Nicolle,Grégoire Michaux et al.
Flora Demouchy et al.
The kinase PAR-4/LKB1 is a major regulator of intestinal homeostasis, which prevents polyposis in humans. Moreover, its ectopic activation is sufficient to induce polarization and formation of microvilli-like structures in intestinal cell l...
TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway [0.03%]
TFAP2同源蛋白通过保守的ALX基因途径调控中面部发育
Timothy T Nguyen,Jennyfer M Mitchell,Michaela D Kiel et al.
Timothy T Nguyen et al.
Cranial neural crest development is governed by positional gene regulatory networks (GRNs). Fine-tuning of the GRN components underlies facial shape variation, yet how those networks in the midface are connected and activated remain poorly ...
Excess dietary sugar impairs Drosophila adult stem cells via elevated reactive oxygen species-induced JNK signaling [0.03%]
过量膳食糖通过提高活性氧诱导的JNK信号通路损害果蝇成体干细胞
Wei-Hao Huang,Kreeti Kajal,Ryan Himawan Wibowo et al.
Wei-Hao Huang et al.
High-sugar diets (HSDs) often lead to obesity and type 2 diabetes, both metabolic syndromes associated with stem cell dysfunction. However, it is unclear whether excess dietary sugar affects stem cells. Here, we report that HSD impairs stem...
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation [0.03%]
BRD4结合到活性颅神经嵴增强子上在软骨细胞分化过程中调控RUNX2的活性
Rachel E Musa,Kaitlyn L Lester,Gabrielle Quickstad et al.
Rachel E Musa et al.
Cornelia de Lange syndrome (CdLS) is a congenital disorder featuring facial dysmorphism, postnatal growth deficits, cognitive disability and upper limb abnormalities. CdLS is genetically heterogeneous, with cases arising from mutation of BR...
Energy metabolism modulates the regulatory impact of activators on gene expression [0.03%]
能量代谢调节激活因子对基因表达的调控作用
Sha Qiao,Sebastian Bernasek,Kevin D Gallagher et al.
Sha Qiao et al.
Gene expression is a regulated process fueled by ATP consumption. Therefore, regulation must be coupled to constraints imposed by the level of energy metabolism. Here, we explore this relationship both theoretically and experimentally. A st...
Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis [0.03%]
毒蕈碱受体M4的刺激调节神经前体细胞增殖并促进成人海马神经发生
Lidia I Madrid,Katelyn Hafey,Saurabh Bandhavkar et al.
Lidia I Madrid et al.
Cholinergic signaling plays a crucial role in the regulation of adult hippocampal neurogenesis; however, the mechanisms by which acetylcholine mediates neurogenic effects are not completely understood. Here, we report the expression of musc...