Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification [0.03%]
软骨蛋白聚糖通过抑制经典BMP信号通路依赖的软骨成熟来延缓软骨内骨化过程
Elham Koosha,Connor T A Brenna,Amir M Ashique et al.
Elham Koosha et al.
During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation, including expression of Ihh and Col10a1. Because bone morphogenetic proteins (BMPs) c...
Conditionally mutant animal model for investigating the invasive trophoblast cell lineage [0.03%]
条件性突变动物模型在侵入性滋养层细胞谱系研究中的应用
Khursheed Iqbal,Esteban M Dominguez,Brandon Nixon et al.
Khursheed Iqbal et al.
Placental development involves coordinated expansion and differentiation of trophoblast cell lineages possessing specialized functions. Among the differentiated trophoblast cell lineages are invasive trophoblast cells, which exit the placen...
Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis [0.03%]
感觉神经通过FGF-SHH轴调节牙根形态发生中的祖细胞功能
Fei Pei,Li Ma,Tingwei Guo et al.
Fei Pei et al.
Nerves play important roles in organ development and tissue homeostasis. Stem/progenitor cells differentiate into different cell lineages responsible for building the craniofacial organs. The mechanism by which nerves regulate stem/progenit...
Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina [0.03%]
觉醒的成人神经干细胞：NOX信号作为非洲爪蟾视网膜静止-增殖转换的积极调节因子
Alicia Donval,Cinthia Violeta Hernandez Puente,Anaïs Lainé et al.
Alicia Donval et al.
A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or adult stem cells their specific properties. However, how stem cells control ROS production and scavenging, and how RO...
CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm [0.03%]
CXCL12促进视网膜神经节细胞轴突在视交叉处的穿越
Viet-Hang Le,Clarisse Orniacki,Verónica Murcia-Belmonte et al.
Viet-Hang Le et al.
Binocular vision requires the segregation of retinal ganglion cell (RGC) axons extending from the retina into the ipsilateral and contralateral optic tracts. RGC axon segregation occurs at the optic chiasm, which forms at the ventral dience...
Spliceosome component PHD finger 5A is essential for early B lymphopoiesis [0.03%]
裂隙蛋白5A指状结构域对于早期B淋巴细胞发育必不可少
Rui Zhang,Daoqin Wang,Gui-Xin Ruan et al.
Rui Zhang et al.
The spliceosome, a multi-megadalton ribonucleoprotein complex, is essential for pre-mRNA splicing in the nucleus and ensuring genomic stability. Its precise and dynamic assembly is pivotal for its function. Spliceosome malfunctions can lead...
Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit [0.03%]
产后海马Cajal-Retzius细胞的持久存在对海马回路的建立具有关键作用
Ingvild Lynneberg Glærum,Keagan Dunville,Kristian Moan et al.
Ingvild Lynneberg Glærum et al.
Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. To understand how the persistence of CR cells influences the maturation of hippocampal circuits, we combined a specific transgenic mouse line with...
Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility [0.03%]
Eif4eif1单基因不足会破坏卵母细胞线粒体动力学并导致生育力下降
Yuxi Ding,Zequn He,Yanwei Sha et al.
Yuxi Ding et al.
Infertility affects couples worldwide. Premature ovarian insufficiency (POI) refers to loss of ovarian function before 40 years of age and is a contributing factor to infertility. Several case studies have reported dominant-inherited POI sy...
Marco Massimo,Katherine R Long
Marco Massimo
Programming human cell fate: overcoming challenges and unlocking potential through technological breakthroughs [0.03%]
编程人类细胞命运：通过技术突破克服挑战并释放潜力
Hsiu-Chuan Lin,Aly Makhlouf,Camila Vazquez Echegaray et al.
Hsiu-Chuan Lin et al.
In recent years, there have been notable advancements in the ability to programme human cell identity, enabling us to design and manipulate cell function in a Petri dish. However, current protocols for generating target cell types often lac...