Generation of rat-derived lung epithelial cells in Fgfr2b-deficient mice retains species-specific development [0.03%]
FGFR2B缺乏的小鼠中生成的大鼠来源的肺上皮细胞保持物种特异性发育
Shunsuke Yuri,Yuki Murase,Ayako Isotani
Shunsuke Yuri
Regenerative medicine is a tool to compensate for the shortage of lungs for transplantation, but it remains difficult to construct a lung in vitro due to the complex three-dimensional structures and multiple cell types required. A blastocys...
Intercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina [0.03%]
发育视网膜中穆勒胶质细胞与小胶质细胞的胞间接触及货物传输先于凋亡细胞的清除过程
Michael Morales,Anna P Findley,Diana M Mitchell
Michael Morales
To clarify our understanding of glial phagocytosis in retinal development, we used real-time imaging of larval zebrafish to provide cell-type specific resolution of this process. We show that radial Müller glia frequently participate in mi...
Organogenetic transcriptomes of the Drosophila embryo at single cell resolution [0.03%]
果蝇胚胎单细胞分辨率下的器官发生的转录组
Da Peng,Dorian Jackson,Bianca Palicha et al.
Da Peng et al.
To gain insight into the transcription programs activated during the formation of Drosophila larval structures, we carried out single cell RNA sequencing during two periods of Drosophila embryogenesis: stages 10-12, when most organs are fir...
Choose Development in 2024: serious science, community connections, progressive publishing [0.03%]
2024年选择发展：严肃科学、社区联系、进步出版
James Briscoe,Katherine Brown
James Briscoe
RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration [0.03%]
RhoA 激活蛋白Mcf2lb在群体细胞迁移过程中调节玫瑰花结的完整性
Hannah M Olson,Amanda Maxfield,Nicholas L Calistri et al.
Hannah M Olson et al.
Multicellular rosettes are transient epithelial structures that serve as important cellular intermediates in the formation of diverse organs. Using the zebrafish posterior lateral line primordium (pLLP) as a model system, we investigated th...
In preprints: cellular memory - the tension between old and new identities in the blastema [0.03%]
预印本：细胞记忆 - 疱疹中旧身份和新身份之间的张力
Benjamin Tajer,Jessica L Whited
Benjamin Tajer
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila [0.03%]
果蝇表皮的酪氨酸分解对高蛋白饮食中的代谢平衡和生存至关重要
Hina Kosakamoto,Masayuki Miura,Fumiaki Obata
Hina Kosakamoto
The insect epidermis forms the exoskeleton and determines the body size of an organism. How the epidermis acts as a metabolic regulator to adapt to changes in dietary protein availability remains elusive. Here, we show that the Drosophila e...
Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours [0.03%]
启用邻近标记：使用合成生物学来探讨细胞如何影响其邻居
Mattias Malaguti,Tamina Lebek,Guillaume Blin et al.
Mattias Malaguti et al.
Cell-cell interactions are central to development, but exploring how a change in any given cell relates to changes in the neighbour of that cell can be technically challenging. Here, we review recent developments in synthetic biology and im...
A lissencephaly-associated BAIAP2 variant causes defects in neuronal migration during brain development [0.03%]
与平滑脑回相关的BAIAP2变异体导致大脑发育过程中神经元迁移缺陷
Meng-Han Tsai,Wan-Cian Lin,Shih-Ying Chen et al.
Meng-Han Tsai et al.
Lissencephaly is a neurodevelopmental disorder characterized by a loss of brain surface convolutions caused by genetic variants that disrupt neuronal migration. However, the genetic origins of the disorder remain unidentified in nearly one-...
Mutation of p53 increases the competitive ability of pluripotent stem cells [0.03%]
p53的突变提高了多能干细胞的竞争能力
Salvador Perez Montero,Pranab K Paul,Aida di Gregorio et al.
Salvador Perez Montero et al.
During development, the rate of tissue growth is determined by the relative balance of cell division and cell death. Cell competition is a fitness quality-control mechanism that contributes to this balance by eliminating viable cells that a...