A new experimental evidence-weighted signaling pathway resource in FlyBase [0.03%]
FlyBase中一个新的实验证据加权信号通路资源
Helen Attrill,Giulia Antonazzo,Joshua L Goodman et al.
Helen Attrill et al.
Research in model organisms is central to the characterization of signaling pathways in multicellular organisms. Here, we present the comprehensive and systematic curation of 17 Drosophila signaling pathways using the Gene Ontology framewor...
Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning [0.03%]
Seven-up在神经母细胞中的作用，以指定成人中枢复合神经元的身份并开始解除神经母细胞的委托
Noah R Dillon,Laurina Manning,Keiko Hirono et al.
Noah R Dillon et al.
An unanswered question in neurobiology is how are diverse neuron cell types generated from a small number of neural stem cells? In the Drosophila larval central brain, there are eight bilateral Type 2 neuroblast (T2NB) lineages that express...
Mitochondrial defects triggered by amg-1 mutation elicit UPRmt and phagocytic clearance during spermatogenesis in C. elegans [0.03%]
由amg-1突变触发的线粒体缺陷在秀丽隐杆线虫的精子发生过程中引发UPRmt和吞噬清除作用
Peng Wang,Lianwan Chen,Ning Wang et al.
Peng Wang et al.
Mitochondria are the powerhouses of many biological processes. During spermatogenesis, post-transcriptional regulation of mitochondrial gene expression is mediated by nuclear-encoded mitochondrial RNA-binding proteins (mtRBPs). We identifie...
Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors [0.03%]
Notch信号影响体轴前体细胞的命运决定和HOX基因的诱导
Fay Cooper,Celine Souilhol,Scott Haston et al.
Fay Cooper et al.
The generation of the post-cranial embryonic body relies on the coordinated production of spinal cord neurectoderm and presomitic mesoderm cells from neuromesodermal progenitors (NMPs). This process is orchestrated by pro-neural and pro-mes...
Clare Hurst,Miriam L Gifford
Clare Hurst
Assembly, dynamics and remodeling of epithelial cell junctions throughout development [0.03%]
上皮细胞连接的组装、动态变化及重构在整个发育过程中的作用
Marta Mira-Osuna,Roland Le Borgne
Marta Mira-Osuna
Cell junctions play key roles in epithelial integrity. During development, when epithelia undergo extensive morphogenesis, these junctions must be remodeled in order to maintain mechanochemical barriers and ensure the cohesion of the tissue...
Control of successive unequal cell divisions by neural cell fate regulators determines embryonic neuroblast cell size [0.03%]
神经细胞命运调节因子对连续不等细胞分裂的控制决定了胚胎神经母细胞的大小
Thomas W Mullan,Terry Felton,Janis Tam et al.
Thomas W Mullan et al.
Asymmetric cell divisions often generate daughter cells of unequal size in addition to different fates. In some contexts, daughter cell size asymmetry is thought to be a key input to specific binary cell fate decisions. An alternative possi...
The people behind the papers - Ingvild Lynneberg Glærum, Keagan Dunville and Giulia Quattrocolo [0.03%]
论文背后的科研人们 -Ingvild Lynneberg Glærum, Keagan Dunville 和Giulia Quattrocolo
Cajal-Retzius (CR) cells are transient neurons that control cortical lamination during development. Although most CR cells disappear before birth, a small population persists in the hippocampus postnatally for several months. In a new study...
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [0.03%]
整合的单细胞多组学揭示了晶状体发育和病理的基础调控机制
Jared A Tangeman,Sofia M Rebull,Erika Grajales-Esquivel et al.
Jared A Tangeman et al.
Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause congenital cataracts. We report the first single-cell multiomic atlas of lens development, leveraging snRNA-seq, snATAC-seq and CUT&RUN-seq to ...
In preprints: recapitulation of development and wound healing shapes the spatial organization of glioblastoma [0.03%]
在预印本中：发育和伤口愈合的再现决定了胶质母细胞瘤的空间组织结构
Polina Kameneva,Sabine Taschner-Mandl
Polina Kameneva