Live tracking of basal stem cells of the epidermis during growth, homeostasis and injury response in zebrafish [0.03%]
斑马鱼表皮基本干细胞在生长、稳定及伤后恢复过程的动态追踪
Zhengcheng Liu,Yidan Meng,Ayu Ishikura et al.
Zhengcheng Liu et al.
Basal stem cells of the epidermis continuously differentiate into keratinocytes and replenish themselves via self-renewal to maintain skin homeostasis. Numerous studies have attempted to reveal how basal cells undergo differentiation or sel...
Rikke Hoegsberg Agerskov,Pia Nyeng
Rikke Hoegsberg Agerskov
The autonomic nervous system innervates the pancreas by sympathetic, parasympathetic and sensory branches during early organogenesis, starting with neural crest cell invasion and formation of an intrinsic neuronal network. Several studies h...
Fluctuation of lysosomal protein degradation in neural stem cells of the postnatal mouse brain [0.03%]
产后鼠脑神经干细胞溶酶体蛋白降解的波动
He Zhang,Karan Ishii,Tatsuya Shibata et al.
He Zhang et al.
Lysosomes are intracellular organelles responsible for degrading diverse macromolecules delivered from several pathways, including the endo-lysosomal and autophagic pathways. Recent reports have suggested that lysosomes are essential for re...
Cell division angle predicts the level of tissue mechanics that tune the amount of cerebellar folding [0.03%]
细胞分裂角度可预测调节小脑折叠程度的组织力学水平
Amber G Cook,Taylor V Bishop,Hannah R Crowe et al.
Amber G Cook et al.
Modeling has led to proposals that the amount of neural tissue folding is set by the level of differential expansion between tissue layers and that the wavelength is set by the thickness of the outer layer. Here, we used inbred mouse strain...
Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate [0.03%]
脑下部边界作为由细胞外基质蛋白多糖硫酸软骨素调节的神经前体和干细胞的生态龛
Carmel Hutchings,Yarden Nuriel,Daniel Lazar et al.
Carmel Hutchings et al.
The interplay between neural progenitors and stem cells (NPSCs), and their extracellular matrix (ECM) is a crucial regulatory mechanism that determines their behavior. Nonetheless, how the ECM dictates the state of NPSCs remains elusive. Th...
Fibroblast growth factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac [0.03%]
成纤维细胞生长因子诱导的透镜纤维细胞伸长是由Rho和Rac的逐步活性驱动的
Yuki Sugiyama,Daniel A Reed,David Herrmann et al.
Yuki Sugiyama et al.
The spheroidal shape of the eye lens is crucial for precise light focusing onto the retina. This shape is determined by concentrically aligned, convexly elongated lens fiber cells along the anterior and posterior axis of the lens. Upon diff...
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures [0.03%]
眼外肌干细胞表现出与非肌肉分子特征相关的独特细胞特性
Daniela Di Girolamo,Maria Benavente-Diaz,Melania Murolo et al.
Daniela Di Girolamo et al.
Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs are reported to have greater proliferative and regenerative capacity when compared with those in the limb. A comprehensive understanding of the m...
The people behind the papers - Meng-Han Tsai, Wan-Cian Lin and Jin-Wu Tsai [0.03%]
论文背后的人 - Tsai Meng-Han, Lin Wan-Cian 和 Tsai Jin-Wu
Lissencephaly is a neurodevelopmental disorder characterised by a loss of brain folds. In a new study, Jin-Wu Tsai and colleagues uncover a new variant of BAIAP2 that is associated with lissencephaly. To learn more about the story behind th...
Interplay of Zeb2a, Id2a and Batf3 regulates microglia and dendritic cell development in the zebrafish brain [0.03%]
斑马鱼脑中Zeb2a、Id2a和Batf3的相互作用调控微胶质细胞和树突状细胞的发展
Linh Thi My Nguyen,Shaoli Hassan,Hongru Pan et al.
Linh Thi My Nguyen et al.
In vertebrates, the central nervous system (CNS) harbours various immune cells, including parenchymal microglia, perivascular macrophages and dendritic cells, which act in coordination to establish an immune network to regulate neurogenesis...
Berna Sozen is an Assistant Professor in the Department of Genetics at Yale University, USA. Berna's lab studies early mammalian development, metabolism, and maternal-fetal interactions using mouse and human embryos, as well as stem cell-de...