Developmental regulation of cellular metabolism is required for intestinal elongation and rotation [0.03%]
肠道延长和旋转需要对细胞代谢进行发育调节
Julia K Grzymkowski,Yu-Chun Chiu,Dereje D Jima et al.
Julia K Grzymkowski et al.
Malrotation of the intestine is a prevalent birth anomaly, the etiology of which remains poorly understood. Here, we show that late-stage exposure of Xenopus embryos to atrazine, a widely used herbicide that targets electron transport chain...
The people behind the papers - Julia Grzymkowski and Nanette Nascone-Yoder [0.03%]
论文背后的人 - Julia Grzymkowski 和 Nanette Nascone-Yoder
As the digestive system develops, the gut tube lengthens and convolutes to correctly package the intestine. Intestinal malrotation is a prevalent birth anomaly, but its underlying causes are not well understood. In this new study, Nanette N...
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification [0.03%]
利用神经形态过程中FZD5的时空调节实现有效腹侧中脑特化
Andy Yang,Rony Chidiac,Emma Russo et al.
Andy Yang et al.
The Wnt/β-catenin signaling governs anterior-posterior neural patterning during development. Current human pluripotent stem cell (hPSC) differentiation protocols use a GSK3 inhibitor to activate Wnt signaling to promote posterior neural fa...
The people behind the papers - Amber Cook, Taylor Bishop, Hannah Crowe and Andrew Lawton [0.03%]
论文背后的人 - Amber Cook, Taylor Bishop, Hannah Crowe 和 Andrew Lawton
Most predictions of how brain folding is determined during development are derived from modelling based on adult brains. In this new study, Andrew Lawton and colleagues test multiple predictions of folding by comparing two mouse strains wit...
A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans [0.03%]
F肌动蛋白聚合因子的一个突变抑制了线虫中distal arthrogryposis类型5的PIEZO2致病变异
Xiaofei Bai,Harold E Smith,Luis O Romero et al.
Xiaofei Bai et al.
The mechanosensitive PIEZO channel family has been linked to over 26 disorders and diseases. Although progress has been made in understanding these channels at the structural and functional levels, the underlying mechanisms of PIEZO-associa...
Daniel Doro,Annie Liu,Jia Shang Lau et al.
Daniel Doro et al.
The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development, homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural c...
The people behind the papers - Daniel Doro, Sachiko Iseki and Karen J. Liu [0.03%]
论文背后的人 - Daniel Doro, Sachiko Iseki 和 Karen J. Liu
It has been suggested that bone repair following craniofacial injury could be supported by a stem cell niche in the sutures. A new paper in Development identifies a key role for neural crest-derived progenitors in skull repair and suggests ...
The people behind the papers - Fay Cooper and Anestis Tsakiridis [0.03%]
论文背后的人 - Fay Cooper 和 Anestis Tsakiridis
Neuromesodermal progenitor (NMPs) give rise to neural and mesodermal tissues during axis elongation. In their study, Fay Cooper, Anestis Tsakiridis and colleagues reveal the role of Notch signalling in NMP differentiation and its role in Ho...
Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo [0.03%]
bicoid梯度的远程形成需要在胚胎空间上变化的多个动态模式
Thamarailingam Athilingam,Ashwin V S Nelanuthala,Catriona Breen et al.
Thamarailingam Athilingam et al.
Morphogen gradients provide essential positional information to gene networks through their spatially heterogeneous distribution, yet how they form is still hotly contested, with multiple models proposed for different systems. Here, we focu...
Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm [0.03%]
Sall4通过促进中胚层基因的表达和抑制中胚层中的神经基因来调节后躯干中胚层的发育
Matthew P Pappas,Hiroko Kawakami,Dylan Corcoran et al.
Matthew P Pappas et al.
The trunk axial skeleton develops from paraxial mesoderm cells. Our recent study demonstrated that conditional knockout of the stem cell factor Sall4 in mice by TCre caused tail truncation and a disorganized axial skeleton posterior to the ...