Xuguang Nie,Yasaman Abbasi,Man-Kyo Chung
Xuguang Nie
Piezo1 and Piezo2 are recently reported mechanosensory ion channels that transduce mechanical stimuli from the environment into intracellular biochemical signals in various tissues and organ systems. Here, we show that Piezo1 and Piezo2 dis...
Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium [0.03%]
局部和全局细胞密度的变化引发增殖上皮中三维排列的重新组织
Vanessa Barone,Antonio Tagua,Jesus Á Andrés-San Román et al.
Vanessa Barone et al.
Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes, adopting a shape named 'scutoid' that allows energy minimiza...
CHD4 and SMYD1 repress common transcriptional programs in the developing heart [0.03%]
CHD4和SMYD1在心脏发育过程中抑制共同的转录程序
Wei Shi,Lauren K Wasson,Kerry M Dorr et al.
Wei Shi et al.
Regulation of chromatin states is essential for proper temporal and spatial gene expression. Chromatin states are modulated by remodeling complexes composed of components that have enzymatic activities. CHD4 is the catalytic core of the nuc...
Jason M Ko,Waverly Reginato,Andrew Wolff et al.
Jason M Ko et al.
Adult planarians can grow when fed and degrow (shrink) when starved while maintaining their whole-body shape. It is unknown how the morphogens patterning the planarian axes are coordinated during feeding and starvation or how they modulate ...
The journey of a generation: advances and promises in the study of primordial germ cell migration [0.03%]
一代人的旅程：原始生殖细胞迁移研究的进展与展望
Lacy J Barton,Lorena Roa-de la Cruz,Ruth Lehmann et al.
Lacy J Barton et al.
The germline provides the genetic and non-genetic information that passes from one generation to the next. Given this important role in species propagation, egg and sperm precursors, called primordial germ cells (PGCs), are one of the first...
Embryonic diapause can be induced by nutrient deprivation, but the molecular mechanisms underpinning this process are unclear. A new paper in Development shows that protein and carbohydrate depletion can trigger embryonic diapause via the n...
Nutrient deprivation induces mouse embryonic diapause mediated by Gator1 and Tsc2 [0.03%]
营养匮乏通过Gator1和Tsc2诱导小鼠胚胎滞育状态
Jiajia Ye,Yuting Xu,Qi Ren et al.
Jiajia Ye et al.
Embryonic diapause is a special reproductive phenomenon in mammals that helps embryos to survive various harsh stresses. However, the mechanisms of embryonic diapause induced by the maternal environment is still unclear. Here, we uncovered ...
Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues [0.03%]
成骨细胞顶侧伸展及颅缝开放依赖纤维连结蛋白诱导效应
Xiaotian Feng,Helen Molteni,Megan Gregory et al.
Xiaotian Feng et al.
The skull roof, or calvaria, is comprised of interlocking plates of bones that encase the brain. Separating these bones are fibrous sutures that permit growth. Currently, we do not understand the instructions for directional growth of the c...
CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice [0.03%]
CFAP58参与了牛和小鼠精子头部塑造及鞭毛发生过程
Xiaochao Wei,Xiuge Wang,Chunhong Yang et al.
Xiaochao Wei et al.
CFAP58 is a testis-enriched gene that plays an important role in the sperm flagellogenesis of humans and mice. However, the effect of CFAP58 on bull semen quality and the underlying molecular mechanisms involved in spermatogenesis remain un...
Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis [0.03%]
肺泡形态发生过程中间充质分化中动态的Hippo信号通路活性
Fatima N Chaudhry,Nigel S Michki,Dain L Shirmer et al.
Fatima N Chaudhry et al.
Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary crest myofibroblasts (SCMF) exist transiently in the neonatal distal lung...