The ectodermal loss of ARHGAP29 alters epithelial morphology and disrupts murine palatogenesis [0.03%]
上皮细胞中ARHGAP29基因丢失导致小鼠腭裂样表型
Emily Adelizzi,Lindsey Rhea,Campbell Mitvalsky et al.
Emily Adelizzi et al.
Orofacial clefts, including cleft palate (CP), are among the most common types of birth defects. CP results from a failure of palatal shelf fusion during development. Previous human studies have shown that mutations in the RhoA GTPase Activ...
The people behind the papers - Pablo González-Suárez and Margot Smit [0.03%]
论文背后的人：帕布洛·冈萨雷斯-苏亚雷斯和马戈特·史密斯
In stomatal development, epidermal cells progress through distinct stages as they differentiate into stomatal guard cells, a process orchestrated by closely related basic helix-loop-helix transcription factors. In their work, Pablo Gonzále...
The people behind the papers - Veronica Biga and Cerys Manning [0.03%]
论文背后的人——Veronica Biga和Cerys Manning
Notch target genes HES1 and HES5 mutually repress one another, while also exhibiting oscillatory expression across tissues, to regulate cell fate specification, during mammalian neural tube development. In their work, Veronica Biga, Cerys M...
Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells [0.03%]
利用小鼠内细胞团机械环境增强体外原始内胚层前体细胞的分化
Elena Corujo-Simon,Siiri I Salomaa,Lawrence E Bates et al.
Elena Corujo-Simon et al.
Stem cell-based models resembling murine blastocysts represent a useful system to investigate subsequent developmental processes. While existing cell lines derived from epiblast and trophectoderm can be aggregated to form 'blastoids', some ...
Proteomic profile of hippocampal growth cones through early postnatal development [0.03%]
啮齿动物早期发育过程中海马神经元生长锥的蛋白质组学分析
Maike Krause,Kamilla Aase Kronberg,Paulo J B Girão et al.
Maike Krause et al.
Axonal growth cones rely on local proteomic changes to interpret guidance cues while navigating towards their synaptic targets. Yet the developmental dynamics of their proteome remain poorly understood. By isolating growth cones from the wh...
Zebrafish knock-in lines enabling live visualization of extracellular matrix dynamics during development and regeneration [0.03%]
可在发育和再生过程中活体观察细胞外基质动力学的斑马鱼基因敲入品系
Jingwen Shen,Ranjay Jayadev,Pierre Gillotay et al.
Jingwen Shen et al.
Extracellular matrix (ECM) plays fundamental roles in animal development, regeneration, and disease. The difficulty of tagging endogenous matrix proteins in vertebrates has limited the understanding of ECM composition and dynamics in comple...
The roles of the acetyltransferase domains of the KAT6A and KAT6B in vivo [0.03%]
KAT6A和KAT6B乙酰转移酶结构域的体内功能研究
Tim Thomas,Shezlie Malelang,Yuqing Yang et al.
Tim Thomas et al.
KAT6A (MOZ) and KAT6B (QKF/MORF) are related histone lysine acetyltransferases (KATs) that have a high degree of functional redundancy during development. In the absence of KAT6A embryos undergo an anterior homeotic transformation of the ax...
The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos [0.03%]
SPN-4 Rbfox RNA结合蛋白在早期秀丽隐杆线虫胚胎中选择母源mRNA进行CCR4-NOT依赖性的清除
Caroline A Spike,Dylan M Parker,Tatsuya Tsukamoto et al.
Caroline A Spike et al.
The elimination of maternal mRNAs is an essential feature of the maternal-to-zygotic transition. We report an essential pathway that clears many maternal transcripts from early C. elegans embryos using the Rbfox-related SPN-4 RNA-binding pr...
The people behind the papers - Taylor Guertin and Kimberley D. Tremblay [0.03%]
论文背后的科研工作者-Taylor Guertin和Kimberley D. Tremblay
In both mouse and humans, proper development of both the embryo and its supporting placenta is coordinated through gene expression programmes. However, the individual functions of many of these genes and consequences of their loss remains u...