Planarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth a...
During development, the gastrointestinal tract undergoes patterning along its anterior-posterior axis to define regions with distinct organs and functions. A new paper in Development derives human intestinal organoids from an individual wit...
The people behind the papers - Margret Bülow and Pilar Carrera [0.03%]
论文背后的她们——Margret Bülow和Pilar Carrera
Bez is a Class B scavenger receptor in Drosophila that is yet to be characterised. In a new study, Margret Bülow and colleagues uncover a role for Bez in mobilising lipids from Drosophila adipocytes into the ovary for oocyte maturation. To...
Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds [0.03%]
多个顺式调控元件控制淋巴血管床中prox1a的表达
Virginia Panara,Hujun Yu,Di Peng et al.
Virginia Panara et al.
During embryonic development, lymphatic endothelial cell (LEC) precursors are distinguished from blood endothelial cells by the expression of Prospero-related homeobox 1 (Prox1), which is essential for lymphatic vasculature formation in mou...
The CD36 scavenger receptor Bez regulates lipid redistribution from fat body to ovaries in Drosophila [0.03%]
果蝇脂肪体向卵巢的脂质重新分布受CD36清道夫受体Bez调节
Pilar Carrera,Johanna Odenthal,Katharina S Risse et al.
Pilar Carrera et al.
Lipid distribution in an organism is mediated by the interplay between lipoprotein particles, lipoprotein receptors and class B scavenger receptors of the CD36 family. CD36 is a multifunctional protein mediating lipid uptake, mobilization a...
Enteroendocrine cells (EECs) are specialised cells in the intestinal epithelium that sense nutrients to regulate feeding behaviour. In a new study, Lihua Ye and colleagues demonstrate that the gut microbiota are crucial in supporting EEC ma...
Chunsheng Han
Chunsheng Han
Mammalian spermatogenesis, probably the most complex of all cellular developmental processes, is an ideal model both for studying the specific mechanism of gametogenesis and for understanding the basic rules governing all developmental proc...
Branching topology of the human embryo transcriptome revealed by Entropy Sort Feature Weighting [0.03%]
熵权重揭示的人类胚胎转录组分支拓扑结构
Arthur Radley,Stefan Boeing,Austin Smith
Arthur Radley
Analysis of single cell transcriptomics (scRNA-seq) data is typically performed after subsetting to highly variable genes (HVGs). Here, we show that Entropy Sorting provides an alternative mathematical framework for feature selection. On sy...
Thibaut Brunet is a group leader at the Institut Pasteur in Paris, France, where he works on choanoflagellates (known as 'choanos' for short). These unicellular organisms are close relatives of animals that have the potential to form multic...
Correction: Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death [0.03%]
订正：斑马鱼raptor突变抑制mTORC1活性，由于自噬诱导神经嵴细胞凋亡导致颅面缺陷
Scott K Tucker,Ritika Ghosal,Mary E Swartz et al.
Scott K Tucker et al.
Published Erratum
Development (Cambridge, England). 2024 Apr 15;151(8):dev202900. DOI:10.1242/dev.202900 2024