Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation [0.03%]
Smad4在着床后原条细胞增殖和形态建成中起重要作用，而在着床前可有可无
Robin E Kruger,Tristan Frum,A Sophie Brumm et al.
Robin E Kruger et al.
Bone morphogenic protein (BMP) signaling plays an essential and highly conserved role in embryo axial patterning in animal species. However, in mammalian embryos, which develop inside the mother, early development includes a preimplantation...
The people behind the papers - Julie Klepstad and Luciano Marcon [0.03%]
论文背后的团队——Julie Klepstad和Luciano Marcon博士
The patterning of somites is coordinated by presomitic mesoderm cells through synchronised oscillations of Notch signalling, creating sequential waves of gene expression that propagate from the posterior to the anterior end of the tissue. I...
The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro [0.03%]
时钟和波阵面自我组织模型重现了小鼠体内和体外分节的动态过程
Julie Klepstad,Luciano Marcon
Julie Klepstad
During mouse development, presomitic mesoderm cells synchronize Wnt and Notch oscillations, creating sequential phase waves that pattern somites. Traditional somitogenesis models attribute phase waves to a global modulation of the oscillati...
Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish [0.03%]
血管生成生长因子Angpt1通过与受体Tie1结合调控斑马鱼淋巴管发生所必需的信号通路
Nanami Morooka,Ning Gui,Koji Ando et al.
Nanami Morooka et al.
Development of the vascular system is regulated by multiple signaling pathways mediated by receptor tyrosine kinases. Among them, angiopoietin (Ang)/Tie signaling regulates lymphatic and blood vessel development in mammals. Of the two Tie r...
During alveologenesis, multiple mesenchymal cell types play crucial roles in maximising the lung surface area. In their study, David Ornitz and colleagues define the repertoire of lung fibroblasts, with a particular focus on alveolar myofib...
Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity [0.03%]
拓扑分析识别与胚珠形态多样性相关的细胞模式
Tejasvinee Atul Mody,Alexander Rolle,Nico Stucki et al.
Tejasvinee Atul Mody et al.
Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question through a comparative analysis of ovule morphoge...
Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses [0.03%]
神经元LRP4指导果蝇外周突触的发育、成熟和细胞骨架组织
Alison T DePew,Joseph J Bruckner,Kate M O&#x;Connor-Giles et al.
Alison T DePew et al.
Synaptic development requires multiple signaling pathways to ensure successful connections. Transmembrane receptors are optimally positioned to connect the synapse and the rest of the neuron, often acting as synaptic organizers to synchroni...
Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis [0.03%]
果蝇视叶层结构形成和形态发生的Plexin A两种功能机制
Maria E Bustillo,Jessica Douthit,Sergio Astigarraga et al.
Maria E Bustillo et al.
Visual circuit development is characterized by subdivision of neuropils into layers that house distinct sets of synaptic connections. We find that, in the Drosophila medulla, this layered organization depends on the axon guidance regulator ...
Angad Singh Chandel,Kemal Keseroglu,Ertuğrul M Özbudak
Angad Singh Chandel
Proper embryonic development depends on the timely progression of a genetic program. One of the key mechanisms for achieving precise control of developmental timing is to use gene expression oscillations. In this Review, we examine how gene...
Matthew B Pomaville,Sydney M Sattler,Philip B Abitua
Matthew B Pomaville
Animal evolution is influenced by the emergence of new cell types, yet our understanding of this process remains elusive. This prompts the need for a broader exploration across diverse research organisms, facilitated by recent breakthroughs...